Abstract
The haematological findings in 50 Bahrainis with sickle cell disease are reported. This establishes the existence of the Hb S gene in Bahrain. The mean Hb F level in the Bahraini patients was 13.8%, a value lower than that encountered in sickle cell homozygotes from Kuwait and Saudi Arabia.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Ali S. A. Milder variant of sickle-cell disease in Arabs in Kuwait associated with unusually high level of foetal haemoglobin. Br J Haematol. 1970 Nov;19(5):613–619. doi: 10.1111/j.1365-2141.1970.tb01645.x. [DOI] [PubMed] [Google Scholar]
- BARTLETT R. C. Rapid celluose acetate electrophoresis. II. Qualitative and quantitative hemoglobin fractionation. Clin Chem. 1963 Jun;9:325–329. [PubMed] [Google Scholar]
- CHERNOFF A. I. The human hemoglobins in health and disease. N Engl J Med. 1955 Sep 1;253(9):365–contd. doi: 10.1056/NEJM195509012530905. [DOI] [PubMed] [Google Scholar]
- GRAHAM J. L., GRUNBAUM B. W. A rapid method for microelectrophoresis and quantitation of hemoglobins on cellulose acetate. Am J Clin Pathol. 1963 Jun;39:567–578. doi: 10.1093/ajcp/39.6.567. [DOI] [PubMed] [Google Scholar]
- Gelpi A. P. Benign sickle cell disease in Saudi Arabia: survival estimate and population dynamics. Clin Genet. 1979 Apr;15(4):307–310. doi: 10.1111/j.1399-0004.1979.tb01739.x. [DOI] [PubMed] [Google Scholar]
- HUISMAN T. H., DOZY A. M. Qunatitative determination of the minor hemoglobin component Hb-A2 by DEAE-cellulose chromatography. Anal Biochem. 1961 Aug;2:400–403. doi: 10.1016/0003-2697(61)90017-3. [DOI] [PubMed] [Google Scholar]
- JACKSON J. F., ODOM J. L., BELL W. N. Amelioration of sickle cell disease by persistent fetal hemoglobin. JAMA. 1961 Sep 23;177:867–869. doi: 10.1001/jama.1961.73040380028011b. [DOI] [PubMed] [Google Scholar]
- Perrine R. P., Pembrey M. E., John P., Perrine S., Shoup F. Natural history of sickle cell anemia in Saudi Arabs. A study of 270 subjects. Ann Intern Med. 1978 Jan;88(1):1–6. doi: 10.7326/0003-4819-88-1-1. [DOI] [PubMed] [Google Scholar]
- SINGER K., CHERNOFF A. I., SINGER L. Studies on abnormal hemoglobins. I. Their demonstration in sickle cell anemia and other hematologic disorders by means of alkali denaturation. Blood. 1951 May;6(5):413–428. [PubMed] [Google Scholar]
- Wood W. G., Pembrey M. E., Serjeant G. R., Perrine R. P., Weatherall D. J. Hb F synthesis in sickle cell anaemia: a comparison of Saudi Arab cases with those of African origin. Br J Haematol. 1980 Jul;45(3):431–445. doi: 10.1111/j.1365-2141.1980.tb07163.x. [DOI] [PubMed] [Google Scholar]