Table 3. Indices of Neurodevelopment Assessed at 2 Years.
| Outcome | No./total (%) | Risk difference, % (95% CI)a | Relative risk (95% CI)a | P valueb | |
|---|---|---|---|---|---|
| Minimally invasive surfactant therapy | Control treatment | ||||
| Cognitive or language impairment | 42/183 (23.0) | 47/195 (24.1) | −0.9 (−7.5 to 5.6) | 0.96 (0.73 to 1.27) | .77 |
| Cognitive impairment | 26/171 (15.2) | 34/183 (18.6) | −3.3 (−10.7 to 4.1) | 0.82 (0.54 to 1.27) | .38 |
| BSID-III cognitive composite standard score, median (IQR)c | 95 (80 to 95) [n = 18] | 95 (85 to 105) [n = 19] | |||
| PARCA-R nonverbal cognitive scale standard score, median (IQR)d | 91 (78 to 107) [n = 153] | 92 (75 to 106) [n = 164] | |||
| Language impairment | 29/170 (17.1) | 25/180 (13.9) | 3.5 (−2.6 to 9.6) | 1.25 (0.85 to 1.85) | .25 |
| BSID-III language composite standard score, median (IQR)c | 81 (74 to 106) [n = 18] | 93 (83 to 103) [n = 18] | |||
| PARCA-R language scale standard score, median (IQR)d | 89 (77 to 99) [n = 152] | 88 (79 to 97) [n = 162] | |||
| Cerebral palsy | 9/195 (4.6) | 15/204 (7.4) | −2.7 (−6.3 to 0.9) | 0.63 (0.36 to 1.11) | .11 |
| Visual impairment | 0/193 | 5/204 (2.5) | −2.5 (−4.4 to −0.6) | Not estimable | |
| Hearing impairment | 4/194 (2.1) | 4/205 (2.0) | 0.1 (−2.3 to 2.6) | 1.06 (0.31 to 3.61) | .93 |
Abbreviations: BSID-III, Bayley Scales of Infant and Toddler Development Third Edition; PARCA-R, Parent Report of Children’s Abilities–Revised.
a
Adjusted for gestational age group.
b
P value for relative risk derived from generalized linear model.
c
BSID-III composite scores: population mean (SD), 100 (15); range, 47-153, with higher scores indicating better performance. A score <80 was indicative of moderate to severe disability.
d
PARCA-R standard scores: population mean (SD), 100 (15); range, 10-147, with higher scores indicating better performance. A score <70 was indicative of moderate to severe disability.