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. 1986 Oct;23(5):417–420. doi: 10.1136/jmg.23.5.417

A model system for the analysis of gene exclusion: cystic fibrosis and chromosome 19.

B Wainwright, M Farrall, E Watson, R Williamson
PMCID: PMC1049778  PMID: 3783618

Abstract

We have used multilocus analysis to exclude the cystic fibrosis locus from six polymorphic DNA markers covering most of chromosome 19. A substantial increase in the confidence for exclusion was obtained using the computer programme LINKAGE compared to analysis of pairwise lod scores. A structured approach to the analysis of linkage to autosomal recessive inherited diseases where the biochemical defect is not known is described.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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