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. 1986 Oct;23(5):452–455. doi: 10.1136/jmg.23.5.452

The effects of severe mixed environmental pollution on human chromosomes.

A Katsantoni, S Nakou, I Antoniadou-Koumatou, G B Côté
PMCID: PMC1049783  PMID: 3783622

Abstract

Cytogenetic studies were conducted on healthy young mothers, shortly after child birth, in two residential areas each with an approximate population of 20,000, situated about 25 km from Athens, Greece. One of the areas, Elefsis, is subject to severe mixed industrial pollution, and the other, Koropi, is relatively free of pollution. Chromosomal aberrations were investigated in 16 women from each area in 72 hour lymphocyte cultures treated with gentian violet to enhance any chromosomal instability induced by the pollution. The women were of a comparable socioeconomic level, aged between 20 and 31 years, and with no history of factors associated with mutagenesis. Venous blood samples were taken from the two groups and processed concurrently. The slides were coded and examined independently by two observers, who were unaware of the source of the samples. A total of 100 cells was examined on each sample. The two observers obtained highly comparable results. Women from Elefsis had an average of 0.42 anomalies per cell and those from Koropi had 0.39. The absence of a statistically significant difference between the two groups clearly shows that the severe mixed environmental pollution of Elefsis has no significant visible effect on human chromosomes in most residents. However, two Elefsis women had abnormal results and could be at risk. Their presence is not sufficient to raise significantly their group's average, but the induction by pollution of an increased rate of chromosomal anomalies in only a few people at risk could account for the known association between urban residence and cancer mortality.

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Selected References

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  1. Au W., Butler M. A., Bloom S. E., Matney T. S. Further study of the genetic toxicity of gentian violet. Mutat Res. 1979 Feb;66(2):103–112. doi: 10.1016/0165-1218(79)90054-5. [DOI] [PubMed] [Google Scholar]
  2. Au W., Pathak S., Collie C. J., Hsu T. C. Cytogenetic toxicity of gentian violet and crystal violet on mammalian cells in vitro. Mutat Res. 1978 Nov;58(2-3):269–276. doi: 10.1016/0165-1218(78)90019-8. [DOI] [PubMed] [Google Scholar]
  3. Butler M. G., Sanger W. G., Veonett G. E. Increased frequency of sister-chromatid exchanges in alcoholics. Mutat Res. 1981 Apr;85(2):71–76. doi: 10.1016/0165-1161(81)90022-4. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Ducatman A., Hirschhorn K., Selikoff I. J. Vinyl chloride exposure and human chromosome aberrations. Mutat Res. 1975 Jun;31(3):163–168. doi: 10.1016/0165-1161(75)90085-0. [DOI] [PubMed] [Google Scholar]
  5. Ford A. B., Bialik O. Air pollution and urban factors in relation to cancer mortality. Arch Environ Health. 1980 Nov-Dec;35(6):350–359. doi: 10.1080/00039896.1980.10667519. [DOI] [PubMed] [Google Scholar]
  6. Forni A., Sciame' A., Bertazzi P. A., Alessio L. Chromosome and biochemical studies in women occupationally exposed to lead. Arch Environ Health. 1980 May-Jun;35(3):139–146. doi: 10.1080/00039896.1980.10667481. [DOI] [PubMed] [Google Scholar]
  7. Hook E. B. Human teratogenic and mutagenic markers in monitoring about point sources of pollution. Environ Res. 1981 Jun;25(1):178–203. doi: 10.1016/0013-9351(81)90089-x. [DOI] [PubMed] [Google Scholar]
  8. Hook E. B. Perspective in mutation epidemiology. 2. Epidemiologic and design aspects of studies of somatic chromosome breakage and sister-chromatid exchange. Mutat Res. 1982 Nov;99(3):373–382. doi: 10.1016/0165-1110(82)90053-7. [DOI] [PubMed] [Google Scholar]
  9. Infante P. F. Oncogenic and mutagenic risks in communities with polyvinyl chloride production facilities. Ann N Y Acad Sci. 1976;271:49–57. doi: 10.1111/j.1749-6632.1976.tb23092.x. [DOI] [PubMed] [Google Scholar]
  10. Ledbetter D. H., Riccardi V. M., Au W. W., Wilson D. P., Holmquist G. P. Ring chromosome 15: phenotype, Ag-NOR analysis, secondary aneuploidy, and associated chromosome instability. Cytogenet Cell Genet. 1980;27(2-3):111–122. doi: 10.1159/000131472. [DOI] [PubMed] [Google Scholar]
  11. Nichols W. W. Virus-induced chromosome abnormalities. Annu Rev Microbiol. 1970;24:479–500. doi: 10.1146/annurev.mi.24.100170.002403. [DOI] [PubMed] [Google Scholar]
  12. Nordenson I., Beckman G., Beckman L., Nordström S. Occupational and environmental risks in and around a smelter in northern Sweden. IV. Chromosomal aberrations in workers exposed to lead. Hereditas. 1978;88(2):263–267. doi: 10.1111/j.1601-5223.1978.tb01628.x. [DOI] [PubMed] [Google Scholar]
  13. Waksvik H., Boysen M. Cytogenetic analyses of lymphocytes from workers in a nickel refinery. Mutat Res. 1982 Feb;103(2):185–190. doi: 10.1016/0165-7992(82)90027-6. [DOI] [PubMed] [Google Scholar]
  14. Watanabe T., Endo A., Kato Y., Shima S., Watanabe T., Ikeda M. Cytogenetics and cytokinetics of cultured lymphocytes from benzene-exposed workers. Int Arch Occup Environ Health. 1980;46(1):31–41. doi: 10.1007/BF00377457. [DOI] [PubMed] [Google Scholar]
  15. Watanabe T., Endo A., Kumai M., Ikeda M. Chromosome aberrations and sister chromatid exchanges in styrene-exposed workers with reference to their smoking habits. Environ Mutagen. 1983;5(3):299–309. doi: 10.1002/em.2860050308. [DOI] [PubMed] [Google Scholar]

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