Abstract
The high incidence of chromosome abnormalities in clinically recognised pregnancies is well documented, but experience of these problems at the time of conception is extremely limited. Using donated oocytes from women seeking surgical sterilisation, we have established reliable cytogenetic techniques for chromosome analysis of human pre-embryos. These have resulted in the first report of trisomy 1. The pre-embryo showed no other obvious abnormality in relation to follicular characteristics, embryo morphology, and cleavage kinetics. The usefulness of such data in explaining the high incidence of occult human pregnancy loss and the current poor success following embryo replacement is emphasised.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Angell R. R., Templeton A. A., Aitken R. J. Chromosome studies in human in vitro fertilization. Hum Genet. 1986 Apr;72(4):333–339. doi: 10.1007/BF00290960. [DOI] [PubMed] [Google Scholar]
- Boué J., Bou A, Lazar P. Retrospective and prospective epidemiological studies of 1500 karyotyped spontaneous human abortions. Teratology. 1975 Aug;12(1):11–26. doi: 10.1002/tera.1420120103. [DOI] [PubMed] [Google Scholar]
- Graham J. B., Barrett D. A., 2nd, Blombäck B., Cann H. M., Hardisty R. M., Larrieu M. J., Renwick J. H. A genetic nomenclature for human blood coagulation. Thromb Diath Haemorrh. 1973 Sep 15;30(1):2–11. [PubMed] [Google Scholar]
- Hassold T., Chen N., Funkhouser J., Jooss T., Manuel B., Matsuura J., Matsuyama A., Wilson C., Yamane J. A., Jacobs P. A. A cytogenetic study of 1000 spontaneous abortions. Ann Hum Genet. 1980 Oct;44(Pt 2):151–178. doi: 10.1111/j.1469-1809.1980.tb00955.x. [DOI] [PubMed] [Google Scholar]
- Messinis I. E., Templeton A., Angell R., Aitken J. A comparison of fixed regimens for obtaining human cleaving oocytes for research purposes. Br J Obstet Gynaecol. 1986 Jan;93(1):39–42. doi: 10.1111/j.1471-0528.1986.tb07811.x. [DOI] [PubMed] [Google Scholar]
- Procter S. E., Watt J. L., Gray E. S. Cytogenetic analysis in 100 spontaneous abortions in North-East Scotland. Clin Genet. 1986 Feb;29(2):101–103. doi: 10.1111/j.1399-0004.1986.tb01230.x. [DOI] [PubMed] [Google Scholar]
- Shows T. B., Alper C. A., Bootsma D., Dorf M., Douglas T., Huisman T., Kit S., Klinger H. P., Kozak C., Lalley P. A. International system for human gene nomenclature (1979) ISGN (1979). Cytogenet Cell Genet. 1979;25(1-4):96–116. doi: 10.1159/000131404. [DOI] [PubMed] [Google Scholar]
- Templeton A., van Look P., Lumsden M. A., Angell R., Aitken J., Duncan A. W., Baird D. T. The recovery of pre-ovulatory oocytes using a fixed schedule of ovulation induction and follicle aspiration. Br J Obstet Gynaecol. 1984 Feb;91(2):148–154. doi: 10.1111/j.1471-0528.1984.tb05899.x. [DOI] [PubMed] [Google Scholar]