Abstract
A male child with typical features of Down's syndrome and mosaicism of two trisomic cell lines, trisomy 18 (84%) and trisomy 21 (16%), is reported. Non-disjunction or anaphase lag of chromosomes 18 and 21 could be the cause.
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- Jenkins M. B., Kriel R. L., Boyd L., Barnwell A. Trisomy 21 with 47,+18 lymphocyte cell line: double mitotic nondisjunction. J Med Genet. 1978 Oct;15(5):395–398. doi: 10.1136/jmg.15.5.395. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Marks J. F., Wiggins K. M., Spector B. J. Trisomy 21-trisomy 18 mosaicism in a boy with clinical Down's syndrome. J Pediatr. 1967 Jul;71(1):126–128. doi: 10.1016/s0022-3476(67)80243-9. [DOI] [PubMed] [Google Scholar]
- Warburton D., Yu C. Y., Kline J., Stein Z. Mosaic autosomal trisomy in cultures from spontaneous abortions. Am J Hum Genet. 1978 Nov;30(6):609–617. [PMC free article] [PubMed] [Google Scholar]