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. 1994 Jun;31(6):448–452. doi: 10.1136/jmg.31.6.448

The use of loss of constitutional heterozygosity data to ascertain the location of predisposing genes in cancer families.

M D Teare 1, K Rohde 1, M F Santibáñez Koref 1
PMCID: PMC1049921  PMID: 8071970

Abstract

A method is described to investigate the inheritance of disease predisposition in cancer families. It is an extension of classic genetic linkage analysis, which enables information on loss of constitutional heterozygosity (LOCH) to be incorporated into the model. This adapted model treats LOCH data as additional observations on the disease phenotype. One of the major benefits of this approach is that isolated parent-offspring pairs are now potentially informative for linkage analysis. Examples are presented.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ali I. U., Schweitzer J. B., Ikejiri B., Saxena A., Robertson J. T., Oldfield E. H. Heterogeneity of subcellular localization of p53 protein in human glioblastomas. Cancer Res. 1994 Jan 1;54(1):1–5. [PubMed] [Google Scholar]
  2. Bièche I., Champème M. H., Matifas F., Hacène K., Callahan R., Lidereau R. Loss of heterozygosity on chromosome 7q and aggressive primary breast cancer. Lancet. 1992 Jan 18;339(8786):139–143. doi: 10.1016/0140-6736(92)90208-k. [DOI] [PubMed] [Google Scholar]
  3. Cornelisse C. J. Loss of heterozygosity, chromosome 7q, and breast cancer. Lancet. 1992 Jun 6;339(8806):1423–1424. doi: 10.1016/0140-6736(92)91248-7. [DOI] [PubMed] [Google Scholar]
  4. Devilee P., van Vliet M., van Sloun P., Kuipers Dijkshoorn N., Hermans J., Pearson P. L., Cornelisse C. J. Allelotype of human breast carcinoma: a second major site for loss of heterozygosity is on chromosome 6q. Oncogene. 1991 Sep;6(9):1705–1711. [PubMed] [Google Scholar]
  5. Easton D. F., Bishop D. T., Ford D., Crockford G. P. Genetic linkage analysis in familial breast and ovarian cancer: results from 214 families. The Breast Cancer Linkage Consortium. Am J Hum Genet. 1993 Apr;52(4):678–701. [PMC free article] [PubMed] [Google Scholar]
  6. Knudson A. G., Jr Mutation and cancer: statistical study of retinoblastoma. Proc Natl Acad Sci U S A. 1971 Apr;68(4):820–823. doi: 10.1073/pnas.68.4.820. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Lustbader E. D., Williams W. R., Bondy M. L., Strom S., Strong L. C. Segregation analysis of cancer in families of childhood soft-tissue-sarcoma patients. Am J Hum Genet. 1992 Aug;51(2):344–356. [PMC free article] [PubMed] [Google Scholar]
  8. Saito H., Inazawa J., Saito S., Kasumi F., Koi S., Sagae S., Kudo R., Saito J., Noda K., Nakamura Y. Detailed deletion mapping of chromosome 17q in ovarian and breast cancers: 2-cM region on 17q21.3 often and commonly deleted in tumors. Cancer Res. 1993 Jul 15;53(14):3382–3385. [PubMed] [Google Scholar]
  9. Santibáez-Koref M. F., Birch J. M., Hartley A. L., Jones P. H., Craft A. W., Eden T., Crowther D., Kelsey A. M., Harris M. p53 germline mutations in Li-Fraumeni syndrome. Lancet. 1991 Dec 14;338(8781):1490–1491. doi: 10.1016/0140-6736(91)92303-j. [DOI] [PubMed] [Google Scholar]
  10. Smith S. A., Easton D. F., Evans D. G., Ponder B. A. Allele losses in the region 17q12-21 in familial breast and ovarian cancer involve the wild-type chromosome. Nat Genet. 1992 Oct;2(2):128–131. doi: 10.1038/ng1092-128. [DOI] [PubMed] [Google Scholar]

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