Abstract
Our initial attempt to map NF was directed towards chromosomes 4 and 19, both of which had provided positive evidence for linkage in previous reports. This analysis showed no evidence in support of either hypothesis. Our second attempt at mapping NF was a general search of the genome, analysing a set of markers selected according to their degree of polymorphism, chromosomal location, ease of use, and availability. Data for linkage analysis were obtained from 17 multiplex families which are segregating a gene for NF. Linkage analyses were performed using PAP. Of note is the lod score of +1.17 at a recombination fraction of 0.1 between NF and the centromere of chromosome 17.
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Selected References
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- Carey J. C., Baty B. J., Johnson J. P., Morrison T., Skolnick M., Kivlin J. The genetic aspects of neurofibromatosis. Ann N Y Acad Sci. 1986;486:45–56. doi: 10.1111/j.1749-6632.1986.tb48061.x. [DOI] [PubMed] [Google Scholar]
- Dietz J. N., Robbins T., Cannon L. A., Schwartz C. E., Carey J. C., Johnson J. P., Kivlin J., Skolnick M. H. Linkage analysis of Von Recklinghausen neurofibromatosis: chromosomes 4 and 19. Genet Epidemiol. 1986;3(5):313–321. doi: 10.1002/gepi.1370030504. [DOI] [PubMed] [Google Scholar]
- Ichikawa K., Crosley C. J., Culebras A., Weitkamp L. Coincidence of neurofibromatosis and myotonic dystrophy in a kindred. J Med Genet. 1981 Apr;18(2):134–138. doi: 10.1136/jmg.18.2.134. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Nakamura Y., Leppert M., O'Connell P., Wolff R., Holm T., Culver M., Martin C., Fujimoto E., Hoff M., Kumlin E. Variable number of tandem repeat (VNTR) markers for human gene mapping. Science. 1987 Mar 27;235(4796):1616–1622. doi: 10.1126/science.3029872. [DOI] [PubMed] [Google Scholar]
- Seizinger B. R., Rouleau G. A., Ozelius L. J., Lane A. H., Faryniarz A. G., Chao M. V., Huson S., Korf B. R., Parry D. M., Pericak-Vance M. A. Genetic linkage of von Recklinghausen neurofibromatosis to the nerve growth factor receptor gene. Cell. 1987 Jun 5;49(5):589–594. doi: 10.1016/0092-8674(87)90534-4. [DOI] [PubMed] [Google Scholar]
- Spence M. A., Bader J. L., Parry D. M., Field L. L., Funderburk S. J., Rubenstein A. E., Gilman P. A., Sparkes R. S. Linkage analysis of neurofibromatosis (von Recklinghausen disease). J Med Genet. 1983 Oct;20(5):334–337. doi: 10.1136/jmg.20.5.334. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Willard H. F., Waye J. S., Skolnick M. H., Schwartz C. E., Powers V. E., England S. B. Detection of restriction fragment length polymorphisms at the centromeres of human chromosomes by using chromosome-specific alpha satellite DNA probes: implications for development of centromere-based genetic linkage maps. Proc Natl Acad Sci U S A. 1986 Aug;83(15):5611–5615. doi: 10.1073/pnas.83.15.5611. [DOI] [PMC free article] [PubMed] [Google Scholar]