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. 1995 Mar;32(3):224–226. doi: 10.1136/jmg.32.3.224

Genetic refinement of the chromosome 5q lattice corneal dystrophy type I locus to within a 2 cM interval.

C Y Gregory 1, K Evans 1, S S Bhattacharya 1
PMCID: PMC1050323  PMID: 7783175

Abstract

Lattice corneal dystrophy type I (LCDI) is a relatively common corneal dystrophy which can cause severe visual impairment. Recent studies have suggested a genetic localisation for the disease to chromosome 5q. Independent genetic linkage analysis in a six generation LCDI pedigree confirmed linkage to the 5q region bounded by marker loci IL9 and D5S436 suggesting genetic homogeneity. A maximum two point lod score of 7.51 (theta = 0.03) was obtained with marker D5S393. Multipoint and haplotype data positioned the disease between loci D5S393 and D5S396 corresponding to a genetic distance of 2cM, thus refining linkage sufficiently to allow for physical mapping of this disorder.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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