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. 2023 Aug 16;42(38):2783–2800. doi: 10.1038/s41388-023-02780-w

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Three main mechanisms of back-splicing, such as lariat-driven circularization (exon skipping) (A), intron pairing-driven circularization (B), and RNA binding protein (RBP)‐driven circularization (C) lead to the biogenesis of circRNAs. Alternative processes (D) can also lead to the biogenesis of other special classes of circRNAs, including intergenic circRNAs or rt-circRNAs and f-circRNAs, which are frequently associated with pathological conditions. Created with BioRender.com.