Table 3.

Ongoing clinical trials on cancer-associated circRNAs as biomarkers or therapeutic targets (https://clinicaltrials.gov/).

Study title	Condition or disease	Intervention/treatment	Country of the study	Status of the study
CIRcular and Non-coding RNAs as Clinically USeful Biomarkers in Pancreaticobiliary Cancers (CIRCUS) (NCT04584996)	• Pancreatic Cancer • Biliary Tract Cancer		United Kingdom	Recruiting
A Study of Blood Based Biomarkers for Pancreas Adenocarcinoma (NCT03334708)	• Pancreatic Cancer • Pancreatic Diseases • Pancreatitis • Pancreatic Cyst	• Diagnostic Test: Blood Draw • Diagnostic Test: Tumor Tissue Collection • Diagnostic Test: Cyst Fluid	United States (5 hospitals involved)	Recruiting
Thyroid Nodule Gene Sequencing in a Danish Population (NCT05377736)	• Thyroid Nodule • (Diagnosis) Thyroid Cancer	• Genetic: Molecular analyses	Denmark	Enrolling by invitation
Rediscovering Biomarkers for the Diagnosis and Early Treatment Response in NEN (REBORN) (NCT04464122)	• Neuroendocrine Tumors • Neuroendocrine Neoplasm • Neuroendocrine Tumor Grade 1 • Neuroendocrine Tumor Grade 2 • Neuroendocrine Carcinoma	• Drug: Somatostatin analog; Chemotherapy	Italy	Recruiting
Research on Precise Immune Prevention and Treatment of Glioma Based on Multi-omics Sequencing Data (NCT04792437)	• Transcriptomics • Radiomics • Glioma	• Procedure: Surgery	China	Recruiting
Gene Therapy and Combination Chemotherapy in Treating Patients With AIDS-Related Non-Hodgkin Lymphoma (NCT02337985)	• AIDS-Related Burkitt Lymphoma • AIDS-Related Diffuse Large B-cell Lymphoma • AIDS-Related Plasmablastic Lymphoma • AIDS-Related Primary Effusion Lymphoma • HIV Infection • AIDS-Related Non-Hodgkin Lymphoma	• Drug: Prednisone • Biological: Rituximab • Drug: Etoposide • Drug: Doxorubicin Hydrochloride • Drug: Vincristine Sulfate • Drug: Cyclophosphamide • Biological: Filgrastim • Biological: Lentivirus Vector rHIV7-shI-TAR-CCR5RZ-transduced Hematopoietic Stem/Progenitor Cells	United States	Active, not recruiting