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. 1995 Jul;32(7):546–548. doi: 10.1136/jmg.32.7.546

Confirmation of genetic heterogeneity in familial psoriasis.

D Matthews 1, L Fry 1, A Powles 1, J Weissenbach 1, R Williamson 1
PMCID: PMC1050548  PMID: 7562968

Abstract

Psoriasis affects approximately 2% of the European population and is often familial. Linkage of a subset of psoriasis families to loci on chromosome 17q has recently been reported. We have studied members of a large multiply affected family from the north east of England and analysed genotypes for markers from 17q, including the polymorphic microsatellite markers AFM210xa5, AFM163yg1, AFM044xg3, AFMa353yg1, and AFM217yd19. Two point and multipoint analysis clearly show exclusion of linkage between the telomeric region of 17q and psoriasis in this family. This confirms the genetic heterogeneity of psoriasis and the existence of at least one other major psoriasis locus.

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Selected References

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  1. Baker B. S., Fry L. The immunology of psoriasis. Br J Dermatol. 1992 Jan;126(1):1–9. doi: 10.1111/j.1365-2133.1992.tb08394.x. [DOI] [PubMed] [Google Scholar]
  2. Bos J. D. The pathomechanisms of psoriasis; the skin immune system and cyclosporin. Br J Dermatol. 1988 Feb;118(2):141–155. doi: 10.1111/j.1365-2133.1988.tb01768.x. [DOI] [PubMed] [Google Scholar]
  3. Brandrup F., Holm N., Grunnet N., Henningsen K., Hansen H. E. Psoriasis in monozygotic twins: variations in expression in individuals with identical genetic constitution. Acta Derm Venereol. 1982;62(3):229–236. [PubMed] [Google Scholar]
  4. Christophers E., Henseler T. Patient subgroups and the inflammatory pattern in psoriasis. Acta Derm Venereol Suppl (Stockh) 1989;151:88–110. [PubMed] [Google Scholar]
  5. Elder J. T., Nair R. P., Guo S. W., Henseler T., Christophers E., Voorhees J. J. The genetics of psoriasis. Arch Dermatol. 1994 Feb;130(2):216–224. [PubMed] [Google Scholar]
  6. Farber E. M., Nall M. L., Watson W. Natural history of psoriasis in 61 twin pairs. Arch Dermatol. 1974 Feb;109(2):207–211. [PubMed] [Google Scholar]
  7. Karvonen J., Tilikainen A., Lassus A. HLA antigens in psoriasis. A family study. Ann Clin Res. 1976 Oct;8(5):298–304. [PubMed] [Google Scholar]
  8. Krueger G. G., Bergstresser P. R., Lowe N. J., Voorhees J. J., Weinstein G. D. Psoriasis. J Am Acad Dermatol. 1984 Nov;11(5 Pt 2):937–947. doi: 10.1016/s0190-9622(84)80018-3. [DOI] [PubMed] [Google Scholar]
  9. Lathrop G. M., Lalouel J. M. Easy calculations of lod scores and genetic risks on small computers. Am J Hum Genet. 1984 Mar;36(2):460–465. [PMC free article] [PubMed] [Google Scholar]
  10. Lathrop G. M., Lalouel J. M., Julier C., Ott J. Strategies for multilocus linkage analysis in humans. Proc Natl Acad Sci U S A. 1984 Jun;81(11):3443–3446. doi: 10.1073/pnas.81.11.3443. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Menter A., Barker J. N. Psoriasis in practice. Lancet. 1991 Jul 27;338(8761):231–234. doi: 10.1016/0140-6736(91)90358-v. [DOI] [PubMed] [Google Scholar]
  12. Miller S. A., Dykes D. D., Polesky H. F. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res. 1988 Feb 11;16(3):1215–1215. doi: 10.1093/nar/16.3.1215. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Powles A. V., Baker B. S., Rutman A. J., McFadden J. P., Valdimarsson H., Fry L. Epidermal rupture is the initiating factor for the Koebner response in psoriasis. Acta Derm Venereol. 1990;70(1):35–38. [PubMed] [Google Scholar]
  14. Russell T. J., Schultes L. M., Kuban D. J. Histocompatibility (HL-A) antigens associated with psoriasis. N Engl J Med. 1972 Oct 12;287(15):738–740. doi: 10.1056/NEJM197210122871503. [DOI] [PubMed] [Google Scholar]
  15. STEINBERG A. G., BECKER S. W., Jr, FITZPATRICK T. B., KIERLAND R. R. A genetic and statistical study of psoriasis. Am J Hum Genet. 1951 Sep;3(3):267–281. [PMC free article] [PubMed] [Google Scholar]
  16. Sakkas L. I., Loqueman N., Bird H., Vaughan R. W., Welsh K. I., Panayi G. S. HLA class II and T cell receptor gene polymorphisms in psoriatic arthritis and psoriasis. J Rheumatol. 1990 Nov;17(11):1487–1490. [PubMed] [Google Scholar]
  17. Svejgaard A., Nielsen L. S., Svejgaard E., Nielsen F. K., Hjortshoj A., Zachariae H. HL-A in psoriasis vulgaris and in pustular psoriasis--population and family studies. Br J Dermatol. 1974 Aug;91(2):145–153. doi: 10.1111/j.1365-2133.1974.tb15859.x. [DOI] [PubMed] [Google Scholar]
  18. Tiilikainen A., Lassus A., Karvonen J., Vartiainen P., Julin M. Psoriasis and HLA-Cw6. Br J Dermatol. 1980 Feb;102(2):179–184. doi: 10.1111/j.1365-2133.1980.tb05690.x. [DOI] [PubMed] [Google Scholar]
  19. Tiwari J. L., Lowe N. J., Abramovits W., Hawkins B. R., Park M. S. Association of psoriasis with HLA-DR7. Br J Dermatol. 1982 Feb;106(2):227–230. doi: 10.1111/j.1365-2133.1982.tb00934.x. [DOI] [PubMed] [Google Scholar]
  20. Watson W., Cann H. M., Farber E. M., Nall M. L. The genetics of psoriasis. Arch Dermatol. 1972 Feb;105(2):197–207. [PubMed] [Google Scholar]

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