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. 1996 Jul;33(7):603–606. doi: 10.1136/jmg.33.7.603

Prenatal diagnosis in Treacher Collins syndrome using combined linkage analysis and ultrasound imaging.

S J Edwards 1, A Fowlie 1, M P Cust 1, D T Liu 1, I D Young 1, M J Dixon 1
PMCID: PMC1050672  PMID: 8818950

Abstract

Treacher Collins syndrome is an autosomal dominant disorder of facial development, the features of which include conductive hearing loss and cleft palate. In the current investigation, linkage analysis has been used to make first trimester diagnostic predictions in a pregnancy at high risk of producing an affected child. The results of this analysis predicted that the child would be affected. As predictions of the severity of the disease were not possible, the pregnancy was also assessed by ultrasound imaging. This confirmed the affected diagnosis and predicted that the child would be severely affected.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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