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. 1996 Dec;33(12):1043–1044. doi: 10.1136/jmg.33.12.1043

Exclusion of one pedigree affected by adult onset primary open angle glaucoma from linkage to the juvenile glaucoma locus on chromosome 1q21-q31.

D Avramopoulos 1, G Kitsos 1, E Economou-Petersen 1, M Grigoriadou 1, D Vassilopoulos 1, C Papageorgiou 1, K Psilas 1, M B Petersen 1
PMCID: PMC1050820  PMID: 9004141

Abstract

A locus for autosomal dominant juvenile onset primary open angle glaucoma (POAG) was recently assigned to chromosome region 1q21-q31. In the present study, a large Greek family with autosomal dominant adult onset POAG was investigated using microsatellite markers. Exclusion of linkage of the adult onset POAG gene to the region D1S194-D1S191 was obtained in this pedigree. Therefore, the data provide evidence that juvenile and adult onset POAG are genetically distinct disease entities.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BEIGUELMAN B., PRADO D. RECESSIVE JUVENILE GLAUCOMA. J Genet Hum. 1963 Jun;12:53–54. [PubMed] [Google Scholar]
  2. BIRO I. Notes upon the question of hereditary glaucoma. Ophthalmologica. 1951;122(4):228–228. doi: 10.1159/000301064. [DOI] [PubMed] [Google Scholar]
  3. CROMBIE A. L., CULLEN J. F. HEREDITARY GLAUCOMA OCCURRENCE IN FIVE GENERATIONS OF AN EDINBURGH FAMILY. Br J Ophthalmol. 1964 Mar;48:143–147. doi: 10.1136/bjo.48.3.143. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. François J. Genetics and primary open-angle glaucoma. Am J Ophthalmol. 1966 Apr;61(4):652–665. doi: 10.1016/0002-9394(66)91201-3. [DOI] [PubMed] [Google Scholar]
  5. Gyapay G., Morissette J., Vignal A., Dib C., Fizames C., Millasseau P., Marc S., Bernardi G., Lathrop M., Weissenbach J. The 1993-94 Généthon human genetic linkage map. Nat Genet. 1994 Jun;7(2 Spec No):246–339. doi: 10.1038/ng0694supp-246. [DOI] [PubMed] [Google Scholar]
  6. Kitsos G., Cote G., Psilas K. Un exemple d'hérédité dominante our la transmission du glaucome primitif à angle ouvert dans une région du nord-ouest de la Grèce. J Fr Ophtalmol. 1988;11(12):859–864. [PubMed] [Google Scholar]
  7. Morissette J., Côté G., Anctil J. L., Plante M., Amyot M., Héon E., Trope G. E., Weissenbach J., Raymond V. A common gene for juvenile and adult-onset primary open-angle glaucomas confined on chromosome 1q. Am J Hum Genet. 1995 Jun;56(6):1431–1442. [PMC free article] [PubMed] [Google Scholar]
  8. Petersen M. B., Economou E. P., Slaugenhaupt S. A., Chakravarti A., Antonarakis S. E. Linkage analysis of the human HMG14 gene on chromosome 21 using a GT dinucleotide repeat as polymorphic marker. Genomics. 1990 May;7(1):136–138. doi: 10.1016/0888-7543(90)90531-x. [DOI] [PubMed] [Google Scholar]
  9. Quigley H. A. Open-angle glaucoma. N Engl J Med. 1993 Apr 15;328(15):1097–1106. doi: 10.1056/NEJM199304153281507. [DOI] [PubMed] [Google Scholar]
  10. Richards J. E., Lichter P. R., Boehnke M., Uro J. L., Torrez D., Wong D., Johnson A. T. Mapping of a gene for autosomal dominant juvenile-onset open-angle glaucoma to chromosome Iq. Am J Hum Genet. 1994 Jan;54(1):62–70. [PMC free article] [PubMed] [Google Scholar]
  11. Sheffield V. C., Stone E. M., Alward W. L., Drack A. V., Johnson A. T., Streb L. M., Nichols B. E. Genetic linkage of familial open angle glaucoma to chromosome 1q21-q31. Nat Genet. 1993 May;4(1):47–50. doi: 10.1038/ng0593-47. [DOI] [PubMed] [Google Scholar]
  12. Wiggs J. L., Haines J. L., Paglinauan C., Fine A., Sporn C., Lou D. Genetic linkage of autosomal dominant juvenile glaucoma to 1q21-q31 in three affected pedigrees. Genomics. 1994 May 15;21(2):299–303. doi: 10.1006/geno.1994.1269. [DOI] [PubMed] [Google Scholar]

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