Abstract
Although the presence of a Y specific growth gene(s) (Y growth gene(s) on Yq has widely been accepted, it remains unknown how this gene promotes stature. In this report, we discuss the growth pattern in normal boys and girls and in patients with growth disorders informative for the Y growth gene(s). The results suggest that the Y growth gene(s) augments statural growth by controlling the sex steroid independent childhood growth pattern.
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Selected References
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- Burgoyne P. S., Thornhill A. R., Boudrean S. K., Darling S. M., Bishop C. E., Evans E. P. The genetic basis of XX-XY differences present before gonadal sex differentiation in the mouse. Philos Trans R Soc Lond B Biol Sci. 1995 Nov 29;350(1333):253–261. doi: 10.1098/rstb.1995.0159. [DOI] [PubMed] [Google Scholar]
- Cronk C., Crocker A. C., Pueschel S. M., Shea A. M., Zackai E., Pickens G., Reed R. B. Growth charts for children with Down syndrome: 1 month to 18 years of age. Pediatrics. 1988 Jan;81(1):102–110. [PubMed] [Google Scholar]
- Gilbert E. F., Opitz J. M. Developmental and other pathologic changes in syndromes caused by chromosome abnormalities. Perspect Pediatr Pathol. 1982;7:1–63. [PubMed] [Google Scholar]
- Horton W. A., Rotter J. I., Rimoin D. L., Scott C. I., Hall J. G. Standard growth curves for achondroplasia. J Pediatr. 1978 Sep;93(3):435–438. doi: 10.1016/s0022-3476(78)81152-4. [DOI] [PubMed] [Google Scholar]
- Karlberg J. On the modelling of human growth. Stat Med. 1987 Mar;6(2):185–192. doi: 10.1002/sim.4780060210. [DOI] [PubMed] [Google Scholar]
- Lahn B. T., Ma N., Breg W. R., Stratton R., Surti U., Page D. C. Xq-Yq interchange resulting in supernormal X-linked gene expression in severely retarded males with 46,XYq- karyotype. Nat Genet. 1994 Nov;8(3):243–250. doi: 10.1038/ng1194-243. [DOI] [PubMed] [Google Scholar]
- Laron Z., Lilos P., Klinger B. Growth curves for Laron syndrome. Arch Dis Child. 1993 Jun;68(6):768–770. doi: 10.1136/adc.68.6.768. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ogata T., Matsuo N. Comparison of adult height between patients with XX and XY gonadal dysgenesis: support for a Y specific growth gene(s). J Med Genet. 1992 Aug;29(8):539–541. doi: 10.1136/jmg.29.8.539. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ogata T., Matsuo N. Sex chromosome aberrations and stature: deduction of the principal factors involved in the determination of adult height. Hum Genet. 1993 Jul;91(6):551–562. doi: 10.1007/BF00205079. [DOI] [PubMed] [Google Scholar]
- Ogata T., Matsuo N. Turner syndrome and female sex chromosome aberrations: deduction of the principal factors involved in the development of clinical features. Hum Genet. 1995 Jun;95(6):607–629. doi: 10.1007/BF00209476. [DOI] [PubMed] [Google Scholar]
- Ogata T., Tomita K., Hida A., Matsuo N., Nakahori Y., Nakagome Y. Chromosomal localisation of a Y specific growth gene(s). J Med Genet. 1995 Jul;32(7):572–575. doi: 10.1136/jmg.32.7.572. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Tanner J. M. Normal growth and techniques of growth assessment. Clin Endocrinol Metab. 1986 Aug;15(3):411–451. doi: 10.1016/s0300-595x(86)80005-6. [DOI] [PubMed] [Google Scholar]
