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. 1997 Oct;34(10):817–818. doi: 10.1136/jmg.34.10.817

Characterisation of a satellited non-fluorescent Y chromosome (Y[nfqs]) by FISH.

R S Verma 1, S K Gogineni 1, S M Kleyman 1, R A Conte 1
PMCID: PMC1051087  PMID: 9350813

Abstract

A fetus was prenatally diagnosed as having a Y(nfqs) chromosome which was inherited from the father. With the QFQ technique, the Yqh was observed to be nonfluorescent and contained cytological satellites which were attached to the terminal long arm. The satellites were positively stained by the Ag-NOR technique suggesting that the NORs were active. A battery of DNA probes was used to characterise the Y(nfqs). Hybridisation experiments using a chromosome 15 specific classical satellite DNA probe (D15Z1) and a Yq telomere DNA probe showed that the additional satellited material on Yq originated from 15p, and that the Yq terminal region had been lost. This is the first reported case in which the origin of cytological satellites on Yq has been determined by FISH, but this does not imply that all satellited Y chromosomes are derived from 15p. However, the clinical significance of this Y(nfqs) chromosome remains obscure.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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