Abstract
We report a case of a newborn infant whose mother had systemic lupus erythematosus (SLE) diagnosed before pregnancy. The child had clinical manifestations of neonatal lupus as well as chondrodysplasia punctata and other findings that resemble the congenital anomalies associated with the use of oral anticoagulants, with no history of exposure. We speculate that the combined action of the different maternal autoantibodies may produce the whole spectrum of manifestations.
Full text
PDF


Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Buyon J. P. Neonatal lupus syndromes. Curr Opin Rheumatol. 1994 Sep;6(5):523–529. doi: 10.1097/00002281-199409000-00012. [DOI] [PubMed] [Google Scholar]
- Buyon J. P. Neonatal lupus: bedside to bench and back. Scand J Rheumatol. 1996;25(5):271–276. doi: 10.3109/03009749609104057. [DOI] [PubMed] [Google Scholar]
- Kawashima T., Zappi E. G., Lieu T. S., Sontheimer R. D. Impact of ultraviolet irradiation on expression of SSA/Ro autoantigenic polypeptides in transformed human epidermal keratinocytes. Lupus. 1994 Dec;3(6):493–500. doi: 10.1177/096120339400300612. [DOI] [PubMed] [Google Scholar]
- Le Thi Huong D., Wechsler B., Piette J. C., Bletry O., Godeau P. Pregnancy and its outcome in systemic lupus erythematosus. QJM. 1994 Dec;87(12):721–729. doi: 10.1093/oxfordjournals.qjmed.a068889. [DOI] [PubMed] [Google Scholar]
- Lee L. A., Frank M. B., McCubbin V. R., Reichlin M. Autoantibodies of neonatal lupus erythematosus. J Invest Dermatol. 1994 Jun;102(6):963–966. doi: 10.1111/1523-1747.ep12384148. [DOI] [PubMed] [Google Scholar]
- Menger H., Lin A. E., Toriello H. V., Bernert G., Spranger J. W. Vitamin K deficiency embryopathy: a phenocopy of the warfarin embryopathy due to a disorder of embryonic vitamin K metabolism. Am J Med Genet. 1997 Oct 17;72(2):129–134. [PubMed] [Google Scholar]
- Nguyen T. O., Capra J. D., Sontheimer R. D. Calreticulin is transcriptionally upregulated by heat shock, calcium and heavy metals. Mol Immunol. 1996 Mar-Apr;33(4-5):379–386. doi: 10.1016/0161-5890(95)00149-2. [DOI] [PubMed] [Google Scholar]
- Orth T., Dorner T., Meyer Zum Buschenfelde K. H., Mayet W. J. Complete congenital heart block is associated with increased autoantibody titers against calreticulin. Eur J Clin Invest. 1996 Mar;26(3):205–215. doi: 10.1046/j.1365-2362.1996.120270.x. [DOI] [PubMed] [Google Scholar]
- Pattison N. S., Chamley L. W., McKay E. J., Liggins G. C., Butler W. S. Antiphospholipid antibodies in pregnancy: prevalence and clinical associations. Br J Obstet Gynaecol. 1993 Oct;100(10):909–913. doi: 10.1111/j.1471-0528.1993.tb15105.x. [DOI] [PubMed] [Google Scholar]
- Pauli R. M., Lian J. B., Mosher D. F., Suttie J. W. Association of congenital deficiency of multiple vitamin K-dependent coagulation factors and the phenotype of the warfarin embryopathy: clues to the mechanism of teratogenicity of coumarin derivatives. Am J Hum Genet. 1987 Oct;41(4):566–583. [PMC free article] [PubMed] [Google Scholar]
- Rokeach L. A., Haselby J. A., Meilof J. F., Smeenk R. J., Unnasch T. R., Greene B. M., Hoch S. O. Characterization of the autoantigen calreticulin. J Immunol. 1991 Nov 1;147(9):3031–3039. [PubMed] [Google Scholar]
- Sammaritano L. R., Gharavi A. E., Lockshin M. D. Antiphospholipid antibody syndrome: immunologic and clinical aspects. Semin Arthritis Rheum. 1990 Oct;20(2):81–96. doi: 10.1016/0049-0172(90)90021-7. [DOI] [PubMed] [Google Scholar]
- de Prost Y., Bodemer C. Lupus néonatal. Ann Med Interne (Paris) 1990;141(3):250–252. [PubMed] [Google Scholar]


