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. 1996 Mar;33(3):253–255. doi: 10.1136/jmg.33.3.253

Molecular scanning of candidate mitochondrial tRNA genes in type 2 (non-insulin dependent) diabetes mellitus.

A W Thomas 1, A Edwards 1, E J Sherratt 1, A Majid 1, J Gagg 1, J C Alcolado 1
PMCID: PMC1051881  PMID: 8728705

Abstract

Mitochondrial DNA (mtDNA) gene defects may play a role in the development of non-insulin dependent diabetes mellitus (NIDDM). In order to search for potentially diabetogenic mtDNA defects we have applied the technique of single stranded conformational polymorphism (SSCP) analysis to 124 patients with a history of NIDDM and 40 non-diabetic controls. No new heteroplasmic mutations were detected. However, a variety of homoplasmic variants were found in patients with NIDDM; some of these merit further investigation.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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