The April 1, 2020 article by Chera et al entitled “Plasma Circulating Tumor HPV DNA for the Surveillance of Cancer Recurrence in HPV-Associated Oropharyngeal Cancer” (Journal of Clinical Oncology 10.1200/JCO.19.02444) was published with incorrect data.
After publication, the authors became aware that the IRB determined that some participants with LCCC 1121 and LCCC 1612 consent documents are to be excluded from the study. Of the 115 subjects included in the publication, 70 (61 from LCCC 1121 and 9 from LCCC 1612) had improper consents after review by the IRB.
The authors conducted a reanalysis removing these participants from the research study on the study's results and conclusions. All of the figure panels retain statistical significance due to the large effect sizes associated with ctDNA positivity. However, confidence intervals are wider due to limited sample sizes.
Percentages, time intervals, and number of patients discussed throughout the abstract and article have been updated. Table 1, Figures 1, 2, 3, and 4, and Figure A1 have been updated.
The major conclusions from the study related to the promise of ctHPVDNA for surveillance of recurrence are still supported by the data and thus the conclusions of the article remain unchanged.
This has been corrected as of August 4, 2023.