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. 1982 Dec;36(4):274–278. doi: 10.1136/jech.36.4.274

Risk factors for gall-bladder disease: a cohort study of young women attending family planning clinics

Peter M Layde 1,2, Martin P Vessey 1,2, David Yeates 1,2
PMCID: PMC1052232  PMID: 7166683

Abstract

During 1968-74, 17 032 women aged 25-39 years were recruited to the Oxford/Family Planning Association Contraceptive Study. By the end of August 1981, 227 of these women had suffered surgically confirmed gall-bladder disease during the follow-up period, an incidence of 1·47 per 1000 woman-years. Obesity was by far the strongest risk factor for gall-bladder disease, but late age at first term birth and cigarette smoking also had statistically significant independent effects. The influence of the use of oral contraceptives on risk was small.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bainton D., Davies G. T., Evans K. T., Gravelle I. H. Gallbladder disease. Prevalence in a South Wales industrial town. N Engl J Med. 1976 May 20;294(21):1147–1149. doi: 10.1056/NEJM197605202942103. [DOI] [PubMed] [Google Scholar]
  2. Bennion L. J., Ginsberg R. L., Gernick M. B., Bennett P. H. Effects of oral contraceptives on the gallbladder bile of normal women. N Engl J Med. 1976 Jan 22;294(4):189–192. doi: 10.1056/NEJM197601222940403. [DOI] [PubMed] [Google Scholar]
  3. Bennion L. J., Grundy S. M. Risk factors for the development of cholelithiasis in man (first of two parts). N Engl J Med. 1978 Nov 23;299(21):1161–1167. doi: 10.1056/NEJM197811232992104. [DOI] [PubMed] [Google Scholar]
  4. Braverman D. Z., Johnson M. L., Kern F., Jr Effects of pregnancy and contraceptive steroids on gallbladder function. N Engl J Med. 1980 Feb 14;302(7):362–364. doi: 10.1056/NEJM198002143020702. [DOI] [PubMed] [Google Scholar]
  5. Comess L. J., Bennett P. H., Burch T. A. Clinical gallbladder disease in Pima Indians. Its high prevalence in contrast to Framingham, Massachusetts. N Engl J Med. 1967 Oct 26;277(17):894–898. doi: 10.1056/NEJM196710262771702. [DOI] [PubMed] [Google Scholar]
  6. Diehl A. K., Stern M. P., Ostrower V. S., Friedman P. C. Prevalence of clinical gallbladder disease in Mexican-American, Anglo, and black women. South Med J. 1980 Apr;73(4):438-41, 443. doi: 10.1097/00007611-198004000-00012. [DOI] [PubMed] [Google Scholar]
  7. Friedman G. D., Kannel W. B., Dawber T. R. The epidemiology of gallbladder disease: observations in the Framingham Study. J Chronic Dis. 1966 Mar;19(3):273–292. doi: 10.1016/0021-9681(66)90132-9. [DOI] [PubMed] [Google Scholar]
  8. Hakulinen T. A Mantel-Haenszel statistic for testing the association between a polychotomous exposure and a rare outcome. Am J Epidemiol. 1981 Feb;113(2):192–197. doi: 10.1093/oxfordjournals.aje.a113083. [DOI] [PubMed] [Google Scholar]
  9. Holland C., Heaton K. W. Increasing frequency of gall bladder operations in the Bristol clinical area. Br Med J. 1972 Sep 16;3(5828):672–675. doi: 10.1136/bmj.3.5828.672. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Khosla T., Lowe C. R. Indices of obesity derived from body weight and height. Br J Prev Soc Med. 1967 Jul;21(3):122–128. doi: 10.1136/jech.21.3.122. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Malhotra S. L. Epidemiological study of cholelithiasis among railroad workers in India with special reference to causation. Gut. 1968 Jun;9(3):290–295. doi: 10.1136/gut.9.3.290. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Richardson J. D., Scutchfield F. D., Proudfoot W. H., Benenson A. S. Epidemiology of gallbladder disease in an Appalachian community. Health Serv Rep. 1973 Mar;88(3):241–246. [PMC free article] [PubMed] [Google Scholar]
  13. Richardson J. D., Scutchfield F. D., Proudfoot W. H., Benenson A. S. Epidemiology of gallbladder disease in an Appalachian community. Health Serv Rep. 1973 Mar;88(3):241–246. [PMC free article] [PubMed] [Google Scholar]
  14. Sampliner R. E., Bennett P. H., Comess L. J., Rose F. A., Burch T. A. Gallbladder disease in pima indians. Demonstration of high prevalence and early onset by cholecystography. N Engl J Med. 1970 Dec 17;283(25):1358–1364. doi: 10.1056/NEJM197012172832502. [DOI] [PubMed] [Google Scholar]
  15. Stolley P. D., Tonascia J. A., Tockman M. S., Sartwell P. E., Rutledge A. H., Jacobs M. P. Thrombosis with low-estrogen oral contraceptives. Am J Epidemiol. 1975 Sep;102(3):197–208. doi: 10.1093/oxfordjournals.aje.a112148. [DOI] [PubMed] [Google Scholar]
  16. Vessey M., Doll R., Peto R., Johnson B., Wiggins P. A long-term follow-up study of women using different methods of contraception--an interim report. J Biosoc Sci. 1976 Oct;8(4):373–427. doi: 10.1017/s0021932000010890. [DOI] [PubMed] [Google Scholar]
  17. Williams C. N., Johnston J. L., Weldon K. L. Prevalence of gallstones and gallbladder disease in Canadian Micmac Indian women. Can Med Assoc J. 1977 Oct 8;117(7):758–760. [PMC free article] [PubMed] [Google Scholar]

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