Abstract
An investigation was conducted among all female laboratory workers in the county of Funen to test the hypothesis that work in laboratories during pregnancy increases the risk of spontaneous abortion. Laboratory workers from hospital, university, and other public laboratories and from laboratories in industry were investigated. A socially comparable reference group less exposed to chemicals at work included office workers, technical assistants and designers, physiotherapists, and occupational therapists. Information was obtained through a postal questionnaire study in May 1980 and from hospital records. Neither the occupation in any single category of laboratory nor the alleged exposure to any single chemical during pregnancy showed a significant increase in the odds ratio for spontaneous abortion. A selection bias was found among the non-respondents with respect to both occupation and outcome of pregnancy, but the influence on the results was slight, owing to the small number of non-respondents. The higher rates of hospital admission for spontaneous abortion among the cases compared with the controls indicates that register data are not more valid than self reported data. This leads to several methodological problems that ought to be studied in further detail.
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Selected References
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- Axelsson G., Rylander R. Exposure to anaesthetic gases and spontaneous abortion: response bias in a postal questionnaire study. Int J Epidemiol. 1982 Sep;11(3):250–256. doi: 10.1093/ije/11.3.250. [DOI] [PubMed] [Google Scholar]
- Blomqvist U., Ericson A., Källén B., Westerholm P. Delivery outcome for women working in the pulp and paper industry. Scand J Work Environ Health. 1981 Jun;7(2):114–118. doi: 10.5271/sjweh.2558. [DOI] [PubMed] [Google Scholar]
- Corbett T. H., Cornell R. G., Endres J. L., Lieding K. Birth defects among children of nurse-anesthetists. Anesthesiology. 1974 Oct;41(4):341–344. [PubMed] [Google Scholar]
- Ericson A., Källén B., Meirik O., Westerholm P. Gastrointestinal atresia and maternal occupation during pregnancy. J Occup Med. 1982 Jul;24(7):515–518. [PubMed] [Google Scholar]
- Hansson E., Jansa S., Wande H., Källén B., Ostlund E. Pregnancy outcome for women working in laboratories in some of the pharmaceutical industries in Sweden. Scand J Work Environ Health. 1980 Jun;6(2):131–134. doi: 10.5271/sjweh.2623. [DOI] [PubMed] [Google Scholar]
- Hemminki K., Franssila E., Vainio H. Spontaneous abortions among female chemical workers in Finland. Int Arch Occup Environ Health. 1980 Feb;45(2):123–126. doi: 10.1007/BF01274131. [DOI] [PubMed] [Google Scholar]
- Hemminki K., Niemi M. L., Koskinen K., Vainio H. Spontaneous abortions among women employed in the metal industry in Finland. Int Arch Occup Environ Health. 1980;47(1):53–60. doi: 10.1007/BF00378328. [DOI] [PubMed] [Google Scholar]
- Nordström S., Beckman L., Nordenson I. Occupational and environmental risks in and around a smelter in northern Sweden. III. Frequencies of spontaneous abortion. Hereditas. 1978;88(1):51–54. doi: 10.1111/j.1601-5223.1978.tb01602.x. [DOI] [PubMed] [Google Scholar]
- Olsen J., Heidam L. Z. Analysis of pathological outcome of pregnancy. Scand J Soc Med. 1983;11(1):3–6. doi: 10.1177/140349488301100101. [DOI] [PubMed] [Google Scholar]
- Olsen J. Risk of exposure to teratogens amongst laboratory staff and painters. Dan Med Bull. 1983 Feb;30(1):24–28. [PubMed] [Google Scholar]
- Strandberg M., Sandbäck K., Axelson O., Sundell L. Spontaneous abortions among women in hospital laboratory. Lancet. 1978 Feb 18;1(8060):384–385. doi: 10.1016/s0140-6736(78)91104-2. [DOI] [PubMed] [Google Scholar]
- Tomlin P. J. Health problems of anaesthetists and their families in the West Midlands. Br Med J. 1979 Mar 24;1(6166):779–784. doi: 10.1136/bmj.1.6166.779. [DOI] [PMC free article] [PubMed] [Google Scholar]