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Journal of Epidemiology and Community Health logoLink to Journal of Epidemiology and Community Health
. 1985 Jun;39(2):141–147. doi: 10.1136/jech.39.2.141

Spontaneous abortions and malformations in the offspring of nurses exposed to anaesthetic gases, cytostatic drugs, and other potential hazards in hospitals, based on registered information of outcome.

K Hemminki, P Kyyrönen, M L Lindbohm
PMCID: PMC1052422  PMID: 3925060

Abstract

Nurses working in selected departments of general hospitals in Finland were collected from a central register on health personnel in Finland. Using the Hospital Discharge Register and the Register of Congenital Malformations, case nurses were selected who had had a spontaneous abortion (N = 217) or a malformed child (N = 46) between the years 1973 and 1979. Controls consisted of three nurses who had had a normal birth; the control nurses were matched for age and hospital of employment. Information on exposure in the first trimester of pregnancy was sought through the head nurses of the hospitals. No significant increase in risk of spontaneous abortion or of malformation was observed after exposure to anaesthetic gases (odds ratio for spontaneous abortion 1.2), sterilising gases and soaps, or x-rays. Handling of cytostatic drugs did not affect the frequency of spontaneous abortion but was associated with malformations in the offspring. The odds ratio, based on eight cases, was 4.7 (p = 0.02) when the logistic model was adopted. The results suggest that the exposures investigated, other than cytostatic drugs, do not cause a strong reproductive risk. Further studies are needed, particularly on cytostatic drugs.

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Selected References

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  1. Askrog V., Harvald B. Teratogen effekt af inhalationsanaestetika. Nord Med. 1970 Apr 16;83(16):498–500. [PubMed] [Google Scholar]
  2. Axelsson G., Lütz C., Rylander R. Exposure to solvents and outcome of pregnancy in university laboratory employees. Br J Ind Med. 1984 Aug;41(3):305–312. doi: 10.1136/oem.41.3.305. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Axelsson G., Rylander R. Exposure to anaesthetic gases and spontaneous abortion: response bias in a postal questionnaire study. Int J Epidemiol. 1982 Sep;11(3):250–256. doi: 10.1093/ije/11.3.250. [DOI] [PubMed] [Google Scholar]
  4. Baltzar B., Ericson A., Källén B. Delivery outcome in women employed in medical occupations in Sweden. J Occup Med. 1979 Aug;21(8):543–548. [PubMed] [Google Scholar]
  5. Cohen E. N., Bellville J. W., Brown B. W., Jr Anesthesia, pregnancy, and miscarriage: a study of operating room nurses and anesthetists. Anesthesiology. 1971 Oct;35(4):343–347. doi: 10.1097/00000542-197110000-00005. [DOI] [PubMed] [Google Scholar]
  6. Cohen E. N., Brown B. W., Jr, Bruce D. L., Cascorbi H. F., Corbett T. H., Jones T. W., Whitcher C. E. A survey of anesthetic health hazards among dentists. J Am Dent Assoc. 1975 Jun;90(6):1291–1296. doi: 10.14219/jada.archive.1975.0270. [DOI] [PubMed] [Google Scholar]
  7. Cohen E. N., Gift H. C., Brown B. W., Greenfield W., Wu M. L., Jones T. W., Whitcher C. E., Driscoll E. J., Brodsky J. B. Occupational disease in dentistry and chronic exposure to trace anesthetic gases. J Am Dent Assoc. 1980 Jul;101(1):21–31. doi: 10.14219/jada.archive.1980.0345. [DOI] [PubMed] [Google Scholar]
  8. Falck K., Gröhn P., Sorsa M., Vainio H., Heinonen E., Holsti L. R. Mutagenicity in urine of nurses handling cytostatic drugs. Lancet. 1979 Jun 9;1(8128):1250–1251. doi: 10.1016/s0140-6736(79)91939-1. [DOI] [PubMed] [Google Scholar]
  9. Halling H. Suspected link between exposure to hexachlorophene and malformed infants. Ann N Y Acad Sci. 1979 May 31;320:426–435. [PubMed] [Google Scholar]
  10. Heidam L. Z. Spontaneous abortions among dental assistants, factory workers, painters, and gardening workers: a follow up study. J Epidemiol Community Health. 1984 Jun;38(2):149–155. doi: 10.1136/jech.38.2.149. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Hemminki K., Axelson O., Niemi M. L., Ahlborg G. Assessment of methods and results of reproductive occupational epidemiology: spontaneous abortions and malformations in the offspring of working women. Am J Ind Med. 1983;4(1-2):293–307. [PubMed] [Google Scholar]
  12. Hemminki K., Mutanen P., Saloniemi I., Niemi M. L., Vainio H. Spontaneous abortions in hospital staff engaged in sterilising instruments with chemical agents. Br Med J (Clin Res Ed) 1982 Nov 20;285(6353):1461–1463. doi: 10.1136/bmj.285.6353.1461. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Knill-Jones R. P., Newman B. J., Spence A. A. Anesthetic practice and pregnancy. Controlled survey of male anaesthetists in the United Kingdom. Lancet. 1975 Oct 25;2(7939):807–809. [PubMed] [Google Scholar]
  14. Knill-Jones R. P., Rodrigues L. V., Moir D. D., Spence A. A. Anaesthetic practice and pregnancy. Controlled survey of women anaesthetists in the United Kingdom. Lancet. 1972 Jun 17;1(7764):1326–1328. doi: 10.1016/s0140-6736(72)91048-3. [DOI] [PubMed] [Google Scholar]
  15. Lauwerys R., Siddons M., Misson C. B., Borlee I., Bouckaert A., Lechat M. F., De Temmerman P. Anaesthetic health hazards among Belgian nurses and physicians. Int Arch Occup Environ Health. 1981;48(2):195–203. doi: 10.1007/BF00378441. [DOI] [PubMed] [Google Scholar]
  16. Med M. Prenatal development of lumbar intervertebral articulation. Folia Morphol (Praha) 1982;30(3):285–290. [PubMed] [Google Scholar]
  17. Norppa H., Sorsa M., Vainio H., Gröhn P., Heinonen E., Holsti L., Nordman E. Increased sister chromatid exchange frequencies in lymphocytes of nurses handling cytostatic drugs. Scand J Work Environ Health. 1980 Dec;6(4):299–301. doi: 10.5271/sjweh.2605. [DOI] [PubMed] [Google Scholar]
  18. Pfäffli P., Nikki P., Ahlman K. Halothane and nitrous oxide in end-tidal air and venous blood of surgical personnel. Ann Clin Res. 1972 Oct;4(5):273–277. [PubMed] [Google Scholar]
  19. Rosenberg P. H., Vänttinen H. Occupational hazards to reproduction and health in anaesthetists and paediatricians. Acta Anaesthesiol Scand. 1978;22(3):202–207. doi: 10.1111/aas.1978.22.3.202. [DOI] [PubMed] [Google Scholar]
  20. Rosenberg P., Kirves A. Miscarriages among operating theatre staff. Acta Anaesthesiol Scand Suppl. 1973;53:37–42. doi: 10.1111/j.1399-6576.1974.tb00780.x. [DOI] [PubMed] [Google Scholar]
  21. Sizemore G. W., Health H., 3rd, Carney J. A. Multiple endocrine neoplasia type 2. Clin Endocrinol Metab. 1980 Jul;9(2):299–315. doi: 10.1016/s0300-595x(80)80035-1. [DOI] [PubMed] [Google Scholar]
  22. Tomlin P. J. Health problems of anaesthetists and their families in the West Midlands. Br Med J. 1979 Mar 24;1(6166):779–784. doi: 10.1136/bmj.1.6166.779. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Vessey M. P., Nunn J. F. Occupational hazards of anesthesia. Br Med J. 1980 Sep 13;281(6242):696–698. doi: 10.1136/bmj.281.6242.696. [DOI] [PMC free article] [PubMed] [Google Scholar]

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