Abstract
The effect of moderate to heavy exposure to alcohol and tobacco on the risk of cancer of the hypopharynx is estimated in a case-control study. All incident hypopharyngeal cancer patients in Denmark who were under 75 years of age were compared with incident cases of laryngeal cancer and population sampled controls. The ascertainment of cases and controls took place during March 1980 to March 1982. Thirty-two patients with cancer of the hypopharynx, 321 patients with cancer of the larynx, and 1141 population sampled controls participated in the study. The effect of combined exposure to alcohol and tobacco seemed to be multiplicative rather than additive, a finding which is similar to that in laryngeal cancer patients. However, as there were only small numbers, only major deviations from the additive or multiplicative model for interaction would be detectable.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Keller A. Z., Terris M. The association of alcohol and tobacco with cancer of the mouth and pharynx. Am J Public Health Nations Health. 1965 Oct;55(10):1578–1585. doi: 10.2105/ajph.55.10.1578. [DOI] [PMC free article] [PubMed] [Google Scholar]
- MANTEL N., HAENSZEL W. Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst. 1959 Apr;22(4):719–748. [PubMed] [Google Scholar]
- Olsen J., Sabreo S., Fasting U. Interaction of alcohol and tobacco as risk factors in cancer of the laryngeal region. J Epidemiol Community Health. 1985 Jun;39(2):165–168. doi: 10.1136/jech.39.2.165. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Olsen J., Sabroe S., Lajer M. Welding and cancer of the larynx: a case-control study. Eur J Cancer Clin Oncol. 1984 May;20(5):639–643. doi: 10.1016/0277-5379(84)90010-5. [DOI] [PubMed] [Google Scholar]
- Olsen J., Sabroe S. Occupational causes of laryngeal cancer. J Epidemiol Community Health. 1984 Jun;38(2):117–121. doi: 10.1136/jech.38.2.117. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Pike M. C., Casagrande J., Smith P. G. Statistical analysis of individually matched case-control studies in epidemiology: factor under study a discrete variable taking multiple values. Br J Prev Soc Med. 1975 Sep;29(3):196–201. doi: 10.1136/jech.29.3.196. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Rothman K., Keller A. The effect of joint exposure to alcohol and tobacco on risk of cancer of the mouth and pharynx. J Chronic Dis. 1972 Dec;25(12):711–716. doi: 10.1016/0021-9681(72)90006-9. [DOI] [PubMed] [Google Scholar]
- VOGLER W. R., LLOYD J. W., MILMORE B. K. A retrospective study of etiological factors in cancer of the mouth, pharynx, and larynx. Cancer. 1962 Mar-Apr;15:246–258. doi: 10.1002/1097-0142(196203/04)15:2<246::aid-cncr2820150206>3.0.co;2-5. [DOI] [PubMed] [Google Scholar]