Abstract
Background.
A large literature has examined a broad range of factors associated with increased risk of stroke. Few studies, however, have examined the association between personality and stroke. The present study adopted a systematic approach using a multi-cohort design to examine the associations between Five-Factor Model personality traits (neuroticism, extraversion, openness, agreeableness, and conscientiousness) and incident stroke using data from six large longitudinal samples of adults.
Methods.
Participants (Age range: 16-104 years old, N = 58,105) were from the Midlife in the United States Study (MIDUS), the Health and Retirement Study (HRS), The Understanding Society study (US), the Wisconsin Longitudinal Study (WLS), the National Health and Aging Trends Study (NHATS), and the Longitudinal Internet Studies for the Social Sciences (LISS). Personality traits, demographic factors, clinical and behavioral risk factors were assessed at baseline; stroke incidence was tracked over 7-20 years follow-up.
Results.
Meta-analyses indicated that higher neuroticism was related to a higher risk of incident stroke (Hazard Ratio[HR]= 1.15; 95% Confidence Interval [CI]=1.10-1.20; p<.001), whereas higher conscientiousness was protective (HR = 0.89; 95% CI=0.85-0.93; p<.001). Additional meta-analyses indicated that BMI, diabetes, blood pressure, physical inactivity, and smoking as additional covariates partially accounted for these associations. Extraversion, openness, and agreeableness were unrelated to stroke incidence.
Conclusions.
Similar to other cardiovascular and neurological conditions, higher neuroticism is a risk factor for stroke incidence, whereas higher conscientiousness is a protective factor.
Keywords: personality, stroke, adulthood
Graphical Abstract

Stroke is a leading cause of death worldwide (1), and has life-changing consequences, including limitations in activities of daily living (2), steeper cognitive decline (3) and higher risk of dementia (4). A large literature has examined a broad range of demographic, clinical and behavioral factors associated with increased risk of stroke, (1, 5-9). The present study examined whether personality traits are associated with incident stroke.
Personality traits are relatively enduring emotional, cognitive, and behavioral patterns that characterize people over time (10). Current personality research uses the Five Factor Model (11) or “Big Five” to organize and assess personality within five broad traits: Neuroticism (moody and tense), extraversion (sociable and outgoing), openness (curious and imaginative), agreeableness (cooperative and trusting) and conscientiousness (self-disciplined and responsible). Among these traits, neuroticism and conscientiousness are the most consistently associated with health-related outcomes. Indeed, higher neuroticism and lower conscientiousness are related to higher inflammation (12), steeper cognitive decline (13), and higher risk of Alzheimer’s disease (14) and mortality (15). Recent research has also found an association between higher neuroticism and higher risk of Parkinson’s Disease (16) and vascular dementia (17). Extraversion, openness, and agreeableness are less consistently associated with health-related outcomes (12, 14).
There is indirect evidence for an association between personality and stroke. Higher neuroticism and lower conscientiousness, for example, have been related to higher cardiovascular risk (18, 19) and higher risk of heart disease (20). In addition, higher neuroticism and lower conscientiousness are associated with several leading clinical and behavioral causes of stroke, such as higher BMI (21), higher risk of diabetes and hypertension (20), smoking (22) and physical inactivity (23). Few studies, however, have examined the association between personality and stroke. The evidence has been inconsistent with stroke-related mortality: While no association was found in one study (24), a later and larger study found that higher extraversion and lower conscientiousness were related to a higher risk of stroke-related mortality (25). But at least 80% of strokes are non-fatal (26), and only a few studies have examined the association between personality and incident stroke. One study found that lower conscientiousness and lower openness were associated with a higher risk of stroke over four years in the Health and Retirement Study (27) Given the differences across outcomes, personality measures, and analytic approaches in the published studies, it is difficult to assess whether there are replicable associations between personality traits and risk of incident stroke. To complement previous research, large multi-cohort research is needed to examine the associations between personality and incident stroke.
The present study examined the associations between FFM personality traits and incident stroke using data from six large longitudinal samples of adults. Such coordinated analysis tests the generalizability, replicability, and robustness of an effect across samples that may differ in measurement, follow-up, culture, and age range. Higher neuroticism and lower conscientiousness were expected to relate to higher risk of stroke, given that these traits are consistently associated with risk of cardiovascular disease (20) and leading clinical and behavioral causes of stroke, such as physical inactivity, smoking, obesity, hypertension, and diabetes (20-23). Given the inconsistency reported in existing research (25,27), no specific hypothesis was formulated for extraversion, openness, and agreeableness. Further analyses were conducted to test whether clinical (e.g., BMI, diabetes, and blood pressure) and behavioral (physical inactivity and smoking) factors accounted for the association between personality and incident stroke in each sample.
Method
Participants
The present study reports against STROBE guidelines. It used publicly available de-identified data and was exempt from Institutional Review Board (IRB) review. Links to data and studies materials are provided below for each sample; data can be obtained directly from each parent study. Written informed consent was obtained from participants in each sample. Participants were included if they had complete data on personality and covariates at baseline and reported on stroke at baseline and on at least one follow-up assessment. In each sample, individuals with stroke at baseline were excluded for the main analysis because the focus was on incident stroke. Descriptive statistics for the six samples are in Table 1.
Table 1.
Descriptive Statistics for the Six Samples
| MIDUS | HRS | US | WLS | NHATS | LISS | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Variables | M/% | SD | M/% | SD | M/% | SD | M/% | SD | M/% | SD | M/% | SD |
| Age (Years) | 47.22 | 12.37 | 67.78 | 9.54 | 46.35 | 17.35 | 53.12 | 0.91 | 78.93 | 7.29 | 45.85 | 15.75 |
| Sex (% women) | 55% | - | 59% | - | 57% | - | 54% | - | 59% | - | 55% | - |
| Race (% African American/Black) | 4% | - | 11% | - | 14%a | - | 0% | - | 20% | - | - | - |
| Ethnicity (% Hispanic) | - | - | 7% | - | - | - | 0% | - | 5% | - | - | - |
| Education | 7.12 | 2.46 | 12.90 | 2.92 | 7.34 | 6.16 | 13.81 | 2.40 | 5.27 | 2.29 | 3.43 | 1.51 |
| Neuroticism | 2.22 | 0.66 | 2.04 | 0.61 | 3.56 | 1.44 | 3.21 | 0.97 | 2.21 | 0.85 | 2.58 | 0.67 |
| Extraversion | 3.19 | 0.56 | 3.21 | 0.55 | 4.60 | 1.30 | 3.82 | 0.90 | 3.15 | 0.75 | 3.29 | 0.63 |
| Openness | 3.01 | 0.51 | 2.96 | 0.55 | 4.58 | 1.30 | 3.64 | 0.79 | 2.83 | 0.83 | 3.52 | 0.50 |
| Agreeableness | 3.48 | 0.49 | 3.54 | 0.47 | 5.64 | 1.04 | 4.74 | 0.74 | 3.58 | 0.54 | 3.91 | 0.49 |
| Conscientiousness | 3.45 | 0.43 | 3.38 | 0.47 | 5.48 | 1.10 | 4.84 | 0.69 | 3.22 | 0.73 | 3.73 | 0.52 |
| Incident Stroke (%) | 2% | 10% | 1% | 5% | 10% | 2% | ||||||
Note. MIDUS: N= 3960; HRS: N= 11,015; US: N= 27066; WLS: N= 8823; NHATS: N= 2319, LISS: = 4922.
Percent of non-white participants.
The Midlife in the United States Survey (MIDUS) is a longitudinal study of non-institutionalized US adults. The follow-up ranged from January 1995 to June 2014. At baseline, 6,093 individuals had complete data on personality, demographic factors, and stroke diagnosis. Stroke diagnosis at follow-up was obtained in 2004-2006 and 2013-2014 from 3,977 participants. The final sample had 3,960 participants aged 20 to 75 years (55% women; Mean Age= 47.22; SD= 12.37). MIDUS data is available at http://midus.wisc.edu/index.php.
The Health and Retirement Study (HRS) is a nationally representative longitudinal study of Americans 50 years and older and their spouse. Baseline data on personality traits, demographic factors, and information on stroke diagnosis were obtained in 2006 and 2008 resulting in a baseline sample composed of 12,650 participants. Data on stroke was collected every two years, with follow-up ranging from March 2006 to May 2021. From the baseline sample, 11,741 participants had information on stroke diagnosis at follow-up. The final sample had 11,015 individuals aged 50 to 104 years (59% women; Mean Age= 67.78; SD= 9.54). HRS data is available at https://hrs.isr.umich.edu/data-products.
The Understanding Society (US) study is a large, nationally representative household panel study. A total of 32,968 participants provided personality, demographic factors and stroke diagnosis in Wave 3 (2011-2012). Stroke diagnosis was assessed every year up to Wave 11, with follow-up ranging from January 2011 to May 2021. Of the baseline sample, 27,476 participants had information on stroke diagnosis at follow-up. The final sample had 27,066 participants aged 16 to 99 (57% women, mean age=46.35, SD=17.35). US data are available at: https://www.understandingsociety.ac.uk/documentation/access-data.
The Wisconsin Longitudinal Study is a longitudinal study of a random sample of 10,317 men and women who graduated from Wisconsin high schools in 1957 and their selected siblings. Personality and demographic factors were obtained in 1992-1994 from a total of 10,072 participants. Follow-up stroke diagnosis was collected in 2003-2007 and 2011. The follow-up period ranged from July 1992 to February 2013. Of the baseline sample, a total of 8,904 participants had information on stroke at follow-up. The final sample had 8,823 participants aged 29 to 75 years (54% women, mean age=53.12, SD=0.91). WLS data is available at http://www.ssc.wisc.edu/wlsresearch/data/.
The National Health and Aging Trends Study (NHATS) is a nationally representative survey of Medicare enrollees aged 65 years and older. Baseline data on personality, demographic factors and stroke diagnosis were obtained in 2013 and 2014 from 2,764 participants. Data on stroke diagnosis were obtained every year up to 2021. The follow-up period ranged from June 2013 to November 2021. Of the baseline sample, 2,389 individuals had data on stroke diagnosis at follow-up. The final sample had 2,319 participants aged 67 to 101 years (59% women, mean age = 78.93, SD = 7.29). NHATS data are available at: http://www.nhats.org.
The Longitudinal Internet Studies for the Social Sciences (LISS) is a representative longitudinal sample of the Dutch population. Data on personality, demographic factors, and stroke were obtained in 2007 from 5,794 participants. Data on stroke diagnosis were collected every year up to 2021 from 4,964 participants within the baseline sample. The follow-up period ranged from November 2007 to December 2021. The final sample had 4,922 participants aged 16 to 94 years (55% women, mean age = 45.85, SD = 15.75). More information about the LISS panel can be found at: www.lissdata.nl.
Measures
Personality.
The five personality traits were assessed using the Midlife Development Inventory (28) in the HRS, MIDUS, and NHATS. A 26-item version was used in the HRS, a 25-item version was used in the MIDUS, and a 10-item version was used in the NHATS. Participants rated how well adjectives representing the five traits described themselves. Example items are worrying (neuroticism), talkative (extraversion), imaginative (openness), warm (agreeableness), and organized (conscientiousness). Answers were given on a scale from 1 (not at all) to 4 (a lot). The Big Five Inventory (29) was used in the WLS and the US. A 29-item version was used in the WLS and a 15-item version was used in the US. Participants rated descriptive statements about the extent to which they see themselves as someone: “who worries a lot?” (neuroticism), “who is talkative?” (extraversion), “who has an active imagination?” (openness), “who is considerate to almost everyone?” (agreeableness) and “who does things efficiently?” (conscientiousness). Answers were given on a 6-point scale from 1 (disagree strongly) to 6 (agree strongly) in the WLS and from 1 (does not apply to me at all) to 7 (applies to me perfectly) in the US. The LISS used the International Personality Item Pool (30). Participants rated how accurately 50 items describe themselves. Example items are: “get stressed out easily” (neuroticism), “talk to a lot of different people at parties” (extraversion), “have a vivid imagination” (openness), “am interested in people” (agreeableness), and “like order” (conscientiousness). A scale from 1 (very inaccurate) to 5 (very accurate) was used to rate answers. A large item response theory (IRT) study found that FFM inventories were largely measurement invariant, with very high correlations (>.90) between estimated latent IRT scores and sum scores (31). Cronbach alphas for neuroticism, extraversion, openness, agreeableness, and conscientiousness ranged respectively from .70 to .88, .61 to .86, .60 to .79, .57 to .81, and .54 to .77 to across samples. Personality traits were z-scored in each sample to facilitate interpretation.
Stroke diagnosis.
In the HRS, WLS, and US, participants were asked to indicate whether a doctor ever told them that they had a stroke. In the US, at follow-up, a question asked whether a doctor or other health professional newly diagnosed them as having a stroke. In the MIDUS, participants indicated whether they experienced or had been treated for stroke in the past twelve months. The NHATS asked whether a doctor told them that they had a stroke since the last interview. In the LISS, participants were asked whether they were told by a physician this last year that they suffered from a stroke or brain infarction, or a disease affecting the blood vessels in the brain. Answers were reported with a yes/no format in each sample.
Covariates.
In the six samples, age (in years), sex (coded as 1 for female and 0 for male), and education were controlled. Years of education were reported in the HRS and WLS, MIDUS used a scale from 1 (no grade school) to 12 (doctoral level degree), NHATS used a scale from 1 (no schooling completed) to 9 (Master’s, professional or doctoral degree), LISS used a scale from 1 (primary school) to 6 (University), and US used a scale from 0 (none reported) to 16 (higher degree). Race was controlled for in HRS, MIDUS, NHATS (all coded 1 for African American and 0 for other) and US (coded 1 for non-white and 0 for other). Ethnicity (coded 1 for Hispanic and 0 for not Hispanic) was included as a covariate in HRS and NHATS.
Additional analyses included smoking, BMI, diabetes, blood pressure, and physical activity as covariates. Smoking was coded as 1 for current/former smoker and 0 for never smoker in all samples. BMI was computed as kg/m2 based on self-reported height and weight in MIDUS, WLS, LISS, and NHATS and on staff-assessed weight and height in HRS and US. Participants also indicated whether they had been diagnosed with diabetes or high blood pressure (yes/no) in all samples. In the HRS, two items that asked how often individuals participated in vigorous and moderate physical activity on a scale from 1 (hardly ever or never) to 4 (more than once a week) were averaged. In the MIDUS, participants were asked to indicate the frequency of their vigorous and moderate leisure physical activity during both the summer and winter months. Answers on a scale from 1 (never) to 6 (several times a week or more) were averaged. In the NHATS, participants indicated whether they ever go walking for exercise and whether they ever spent time on vigorous activities in the last month. For each item, answers were given using a yes/no format and summed. In the WLS, participants were asked how often they participated in light and vigorous physical activity using a scale ranging from 1 (less than once per month) to 4 (three or more times per week). In the US cohort, an item asked participants how often in the last 12 months they did sport, on a scale ranging from 1 (do not do any sport) to 7 (more than three times a week). In the LISS, two items that asked how many days a week participants performed strenuous and moderate activities were averaged.
Statistical Analysis
Cox proportional hazard survival models were used to test whether personality traits were associated with risk of incident stroke in the six samples. Time-to-incidence was coded in years from baseline to the year in which participants were diagnosed with stroke. Participants who had no stroke were censored at the last available assessment. Personality traits were entered as predictors of time-to-incidence in separate analyses. Age, sex, and education were controlled in the six samples. Race was controlled in the MIDUS, the HRS, the NHATS, and the US. Ethnicity was controlled in the HRS and the NHATS. Additional Cox survival analyses were conducted including clinical and behavioral covariates. The interactions between predictors and time were tested to evaluate the proportional hazards assumption. The proportional hazard assumption was met in the six samples. Random-effect meta-analyses were conducted with the Comprehensive Meta-Analysis software. I2 indicator was used to quantify heterogeneity between samples.
Sensitivity analyses excluded participants with stroke-related mortality. Causes of mortality were available in the MIDUS and the HRS. In the MIDUS, causes of death were based on the International Classification of Disease ninth (ICD-9) and tenth (ICD-10) revision. Individuals coded as I60-I69 (stroke) were excluded from the analysis. In the HRS, causes of death were categorized based on ICD-10 were available up to 2016. Participants with the code 123 (stroke; cerebral hemorrhage or accident; hematoma (if related to brain); transient ischemic attack) were excluded.
Results
The median follow-up was 17.83 years (58,580 person-years; MIDUS), 10.34 years (109,034 person-years; HRS), 7.87 years (176,747 person-years; US), 17.33 years (143,607 person-years; WLS), 5.92 years (11,911 person-years; NHATS), and 9 years (40,652 person-years; LISS). The percentage of individuals who had a stroke over time was 2% (N= 68; MIDUS), 10% (N= 1,140; HRS), 1% (N= 359; US), 5% (N= 413; WLS), 10% (N= 242; NHATS), and 2% (N= 91; LISS).
Consistent with the hypothesis, the meta-analysis indicated that higher neuroticism was associated with higher incident stroke, whereas higher conscientiousness was associated with lower risk of incident stroke, controlling for demographic factors (Table 2). There was little evidence of heterogeneity across the samples. Neuroticism was related to incident stroke in five out of six samples; conscientiousness was significantly associated with stroke in four out of six samples (Table 2). The results suggested that one SD higher neuroticism was associated with 11-35% higher risk of incident stroke, and one SD higher conscientiousness was associated with 11-39% lower risk of incident stroke.
Table 2.
Summary of Cox Regression Analysis Predicting Risk of Incident Stroke from Personality Traits in the Six Samples
| MIDUS a | HRS b | USa | WLS c | NHATSb | LISSc | Pooled Hazard Ratio |
Heterogeneity I2 |
|
|---|---|---|---|---|---|---|---|---|
| Neuroticism | 1.35* (1.06-1.72) |
1.14*** (1.07-1.21) |
1.19** (1.08-1.32) |
1.11* (1.01-1.23) |
1.17* (1.03-1.33) |
1.14 (0.93-1.41) |
1.15*** (1.10-1.20) |
0 |
| Extraversion | 0.90 (0.71-1.14) |
0.96 (0.91-1.02) |
1.05 (0.95-1.16) |
0.93 (0.84-1.02) |
1.04 (0.91-1.18) |
1.06 (0.86-1.32) |
0.98 (0.94-1.02) |
3.83 |
| Openness | 1.07 (0.83-1.36) |
0.95 (0.90-1.01) |
0.99 (0.90-1.10) |
1.00 (0.90-1.10) |
0.96 (0.84-1.09) |
1.04 (0.84-1.29) |
0.97 (0.93-1.01) |
0 |
| Agreeableness | 0.96 (0.75-1.24) |
0.99 (0.93-1.05) |
0.99 (0.89-1.10) |
0.98 (0.89-1.08) |
0.99 (0.87-1.12) |
1.08 (0.86-1.36) |
0.99 (0.95-1.03) |
0 |
| Conscientiousness | 0.72** (0.58-0.90) |
0.90*** (0.85-0.96) |
0.93 (0.84-1.03) |
0.89* (0.81-0.98) |
0.84** (0.74-0.95) |
0.96 (0.77-1.19) |
0.89*** (0.85-0.93) |
9.93 |
Note. MIDUS: N= 3960; HRS: N= 11,015; US: N= 27066; WLS: N= 8823; NHATS: N= 2319; LISS= 4922
Adjusted for age, sex, education, and race
Adjusted for age, sex, education, race, and ethnicity
Adjusted for age, sex, and education
p < .05
p < .01
p <.001
Smoking, BMI, physical, activity, blood pressure and diabetes partially accounted for the associations between personality traits and incident stroke, which remained significant even after accounting for these behavioral and clinical covariates (Table 3). Extraversion, openness, or agreeableness were unrelated to risk of incident stroke in all samples (Table 2 and Table 3). Figure 1 shows a forest plot with the effects from each sample and the overall meta-analytic effect for neuroticism and conscientiousness adjusting for demographic covariates (Panel A and B) and adjusting for demographic, clinical and behavioral covariates (Panel C and D) .
Table 3.
Summary of Cox Regression Analysis Predicting Risk of Incident Stroke from Personality Traits in the Six Samples, Controlling for Behavioral and Clinical Factors
| MIDUS a | HRS b | USa | WLS c | NHATSb | LISSc | Pooled Hazard Ratio |
Heterogeneity I2 |
|
|---|---|---|---|---|---|---|---|---|
| Neuroticism | 1.42* (1.09-1.86) |
1.08* (1.01-1.15) |
1.34** (1.09-1.65) |
1.04 (0.94-1.15) |
1.14 (1.00-1.30) |
1.12 (0.91-1.37) |
1.13** (1.05-1.21) |
44.37 |
| Extraversion | 1.00 (0.61-1.30) |
1.02 (0.95-1.09) |
0.87 (0.71-1.06) |
0.96 (0.87-1.06) |
1.08 (0.95-1.23) |
1.05 (0.85-1.30) |
1.00 (0.96-1.05) |
0 |
| Openness | 1.12 (0.86-1.46) |
0.98 (0.92-1.05) |
0.88 (0.71-1.08) |
1.02 (0.92-1.14) |
0.98 (0.86-1.12) |
1.04 (0.84-1.30) |
0.99 (0.95-1.04) |
0 |
| Agreeableness | 0.95 (0.73-1.23) |
1.02 (0.96-1.10) |
0.88 (0.72-1.08) |
1.04 (0.94-1.15) |
1.03 (0.90-1.17) |
1.07 (0.85-1.35) |
1.02 (0.97-1.07) |
0 |
| Conscientiousness | 0.73* (0.58-0.93) |
0.95 (0.89-1.01) |
0.93 (0.76-1.14) |
0.95 (0.86-1.05) |
0.86* (0.76-0.98) |
0.99 (0.80-1.23) |
0.92** (0.87-0.98) |
17.89 |
Note. MIDUS: N= 2870; HRS: N= 9239; US: N=8278; WLS: N= 8467; NHATS: N= 2251; LISS= 4907. Diabetes, blood pressure/hypertension, physical inactivity, BMI, and smoking were controlled in the six samples.
Adjusted for age, sex, education, and race
Adjusted for age, sex, education, race, and ethnicity
Adjusted for age, sex, and education
p < .05
p < .01
p <.001
Figure 1.
Forest Plot of the Associations of Neuroticism and Conscientiousness with Risk of Incident Stroke without and with accounting for Behavioral and Clinical Factors.
The pattern of association was unchanged when participants with mortality-related stroke were excluded in the MIDUS (HR neuroticism= 1.32, 95% CI= 1.03-1.69, p=.026; HRconscientiousness= 0.76, 95% CI=.61-.96, p=.019) and the HRS (HR neuroticism= 1.13, 95% CI= 1.07-1.21, p<.001; HRconscientiousness= 0.89, 95% CI= .84-.95, p<.001).
Discussion
Based on six longitudinal samples of more than 55,000 adults, the present study found that higher neuroticism was associated with a higher risk of incident stroke, whereas conscientiousness was associated with a lower risk of stroke. These associations were observed across different samples of different ages, from different countries, over 7 to 20 years of follow-up, controlling for demographic factors, and persisted when clinical and behavioral risk factors were included in the analyses. The present study adds to existing knowledge on the association between personality and stroke (25, 27) by testing the largest overall sample with the longest follow-up.
Several clinical and behavioral pathways could explain the link between neuroticism and conscientiousness and stroke. Indeed, higher neuroticism is related to higher BMI (21), higher risk of diabetes and hypertension (20), smoking (22), and physical inactivity (23), which are leading clinical and behavioral causes of stroke (1, 7). In contrast, higher conscientiousness is associated with more beneficial clinical and behavioral profiles implicated in incident stroke, such as lower risk of obesity (21), smoking (22), diabetes and hypertension (20), and higher physical activity (23). The additional analysis supported this pathway because these clinical and behavioral factors accounted for some of the association between personality and incident stroke. However, other biological and psychological mechanisms may explain these associations. For example, higher neuroticism and lower conscientiousness are associated with higher systemic inflammation (12), which is implicated in incident stroke (32). Based upon recent evidence (33), a stress-related pathway through heightened negative affect reactivity to everyday stressful experiences may also explain part of the association between higher neuroticism and lower conscientiousness and incident stroke over time.
Extraversion, openness, and agreeableness were unrelated to stroke incidence. Although openness was related to lower risk of incident stroke in one previous study (27), this association was not found in any of the six large samples we examined in this study. There is inconsistent or no evidence for a relationship between these traits and cardiovascular risk factors such as blood pressure or diabetes (34, 35), which may explain the lack of association with stroke incidence in the present study.
This study had several limitations. Stroke diagnosis was based on participant report of a stroke diagnosis by a doctor or other health professional and was defined differently across cohorts. Future research is needed to test whether the pattern of associations replicates with medical records. The present study also cannot completely exclude that reverse causality may contribute to the observed associations. Indeed, the underlying pathological changes associated with stroke could lead to higher neuroticism and lower conscientiousness before diagnosis. Contrary to the reverse causality hypothesis, however, the size of the association between personality and incident stroke was urelated to follow-up length. Additional limitations include residual confounding, positive selection effect, data comparability, and the biases related to I2 statistic with the small number of samples included. Finally, future research needs to use more inclusive samples across race and include samples from low and middle income countries.
Despite these limitations, the present research found replicated evidence that higher neuroticism and lower conscientiousness were associated with higher risk of incident stroke. Personality assessment could help identify individuals at risk of stroke and provide insights for tailored interventions. Individuals with higher neuroticism and lower conscientiousness may benefit from behavioral interventions, such as physical activity or smoking cessation programs, which may ultimately lead to lower risk of stroke.
Supplementary Material
Acknowledgments
The Health and Retirement Study (HRS) is sponsored by the National Institute on Aging (NIA-U01AG009740) and conducted by the University of Michigan. The HRS was approved by the University of Michigan IRB. The Midlife in the United States (MIDUS) is sponsored by the MacArthur Foundation Research Network on Successful Midlife Development, the National Institute on Aging (P01-AG020166; U19-AG051426), and grants from the General Clinical Research Centers Program (M01-RR023942, M01-RR00865) and the National Center for Advancing Translational Sciences (UL1TR000427). The MIDUS Study was approved by the Education and Social/Behavioral Sciences and the Health Sciences IRB at the University of Wisconsin-Madison. The National Health and Aging Trends Study (NHATS) is sponsored by the National Institute on Aging (grant number NIA U01AG032947) through a cooperative agreement with the Johns Hopkins Bloomberg School of Public Health. The NHATS was approved by the Johns Hopkins Bloomberg School of Public Health IRB. The Wisconsin Longitudinal Study (WLS) has been supported principally by the National Institute on Aging (AG-9775, AG-21079, AG-033285, and AG-041868), with additional support from the Vilas Estate Trust, the National Science Foundation, the Spencer Foundation, and the Graduate School of the University of Wisconsin-Madison. The WLS received approval from the Health Sciences IRB at University of Wisconsin–Madison. The Understanding Society (US) study is primarily funded by the Economic and Social Research Council (ESRC). The University of Essex Ethics Committee has approved all data collection on Understanding Society. The Longitudinal Internet Studies for the Social Sciences (LISS) panel data were collected by CentERdata (Tilburg University, The Netherlands) through its MESS project funded by the Netherlands Organization for Scientific Research.
Funding Sources:
The research reported in this publication was supported in part by the National Institute on Aging of the National Institutes of Health (grant numbers R01AG068093, R01AG053297). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
Non-standard Abbreviations and Acronyms
- MIDUS
Midlife in the United States Study
- HRS
Health and Retirement Study
- US
Understanding Society
- WLS
Wisconsin Longitudinal Study
- NHATS
National Health and Aging Trends Study
- LISS
Longitudinal Internet Studies for the Social Sciences
Footnotes
Disclosure: Drs Terracciano and Sutin report: National Institute on Aging
References
- 1.GBD 2019 Stroke Collaborators. Global, regional, and national burden of stroke and its risk factors, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet Neurol. 2021;20(10):795–820. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 2.Gil-Salcedo A, Dugravot A, Fayosse A, Landré B, Jacob L, Bloomberg M, Sabia S, Schnitzler A. Pre-stroke Disability and Long-Term Functional Limitations in Stroke Survivors: Findings From More of 12 Years of Follow-Up Across Three International Surveys of Aging. Front Neurol. 2022;13:888119. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 3.Levine DA, Galecki AT, Langa KM, Unverzagt FW, Kabeto MU, Giordani B, Wadley VG. Trajectory of Cognitive Decline After Incident Stroke. JAMA. 2015;314(1):41–51. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 4.Kuźma E, Lourida I, Moore SF, Levine DA, Ukoumunne OC, Llewellyn DJ. Stroke and dementia risk: A systematic review and meta-analysis. Alzheimers Dement. 2018;14(11):1416–1426. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 5.Boehme AK, Esenwa C, Elkind MS. Stroke Risk Factors, Genetics, and Prevention. Circ Res. 2017;120(3):472–495. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 6.Harshfield EL, Georgakis MK, Malik R, Dichgans M, Markus HS. Modifiable Lifestyle Factors and Risk of Stroke: A Mendelian Randomization Analysis. Stroke. 2021;52(3):931–936. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 7.O’Donnell MJ, Chin SL, Rangarajan S, Xavier D, Liu L, Zhang H, Rao-Melacini P, Zhang X, Pais P, Agapay S et al. Global and regional effects of potentially modifiable risk factors associated with acute stroke in 32 countries (INTERSTROKE): a case-control study. Lancet. 2016;388(10046):761–75. [DOI] [PubMed] [Google Scholar]
- 8.Dong JY, Zhang YH, Tong J, Qin LQ. Depression and risk of stroke: a meta-analysis of prospective studies. Stroke. 2012;43(1):32–7. [DOI] [PubMed] [Google Scholar]
- 9.Valtorta NK, Kanaan M, Gilbody S, Ronzi S, Hanratty B. Loneliness and social isolation as risk factors for coronary heart disease and stroke: systematic review and meta-analysis of longitudinal observational studies. Heart. 2016;102(13):1009–16. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 10.Costa PT Jr, McCrae RR, Löckenhoff CE. Personality Across the Life Span. Annu Rev Psychol. 2019;70:423–448. [DOI] [PubMed] [Google Scholar]
- 11.McCrae RR, John OP. An introduction to the five-factor model and its applications. J Pers.1992; 60(2): 175–215. [DOI] [PubMed] [Google Scholar]
- 12.Wright AJ, Weston SJ, Norton S, Voss M, Bogdan R, Oltmanns TF, Jackson JJ. Prospective self- and informant-personality associations with inflammation, health behaviors, and health indicators. Health Psychol. 2022;41(2):121–133. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 13.Sutin AR, Brown J, Luchetti M, Aschwanden D, Stephan Y, Terracciano A. Five-Factor Model Personality Traits and the Trajectory of Episodic Memory: Individual-Participant Meta-analysis of 471,821 Memory Assessments from 120,640 Participants. J Gerontol B Psychol Sci Soc Sci. 2022 [DOI] [PMC free article] [PubMed] [Google Scholar]
- 14.Aschwanden D, Strickhouser JE, Luchetti M, Stephan Y, Sutin AR, Terracciano A. Is personality associated with dementia risk? A meta-analytic investigation. Ageing Res Rev. 2021;67:101269. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 15.Graham EK, Rutsohn JP, Turiano NA, Bendayan R, Batterham PJ, Gerstorf D, Katz MJ, Reynolds CA, Sharp ES, Yoneda TB et al. Personality Predicts Mortality Risk: An Integrative Data Analysis of 15 International Longitudinal Studies. J Res Pers. 2017;70:174–186. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 16.Terracciano A, Aschwanden D, Stephan Y, Cerasa A, Passamonti L, Toschi N, Sutin AR. Neuroticism and Risk of Parkinson’s Disease: A Meta-Analysis. Mov Disord. 2021;36(8):1863–1870. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 17.Terracciano A, Aschwanden D, Passamonti L, Toschi N, Stephan Y, Luchetti M, Lee JH, Sesker A, O’Súilleabháin PS, Sutin AR. Is neuroticism differentially associated with risk of Alzheimer’s disease, vascular dementia, and frontotemporal dementia? J Psychiatr Res. 2021;138:34–40. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 18.Čukić I, Bates TC. The Association between Neuroticism and Heart Rate Variability Is Not Fully Explained by Cardiovascular Disease and Depression. PLoS One. 2015;10(5):e0125882. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 19.Thomas MC, Duggan KA, Kamarck TW, Wright AGC, Muldoon MF, Manuck SB. Conscientiousness and Cardiometabolic Risk: A Test of the Health Behavior Model of Personality Using Structural Equation Modeling. Ann Behav Med. 2022;56(1):100–111. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 20.Weston SJ, Graham EK, Turiano NA, Aschwanden D, Booth T, Harrison F, James BD, Lewis NA, Makkar SR, Mueller S et al. Is Healthy Neuroticism Associated with Chronic Conditions? A Coordinated Integrative Data Analysis. Collabra Psychol. 2020;6(1):42. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 21.Sutin AR, Terracciano A. Personality traits and body mass index: Modifiers and mechanisms. Psychol Health. 2016; 31(3): 259–275. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 22.Hakulinen C, Hintsanen M, Munafo MR, Virtanen M, Kivimaki M, Batty G, Jokela M. Personality and smoking: Individual-participant meta-analysis of nine cohort studies. Addiction 2015; 110(11): 1844–1852. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 23.Sutin AR, Stephan Y, Luchetti M, Artese A, Oshio A, and Terracciano A. The five factor model of personality and physical inactivity: A meta-analysis of 16 samples. J Res Pers. 2016; 63: 22–28. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 24.Shipley BA, Weiss A, Der G, Taylor MD, Deary IJ. Neuroticism, extraversion, and mortality in the UK Health and Lifestyle Survey: a 21-year prospective cohort study. Psychosom Med. 2007;69(9):923–31. [DOI] [PubMed] [Google Scholar]
- 25.Jokela M, Pulkki-Råback L, Elovainio M, Kivimäki M. Personality traits as risk factors for stroke and coronary heart disease mortality: pooled analysis of three cohort studies. J Behav Med. 2014;37(5):881–9. [DOI] [PubMed] [Google Scholar]
- 26.Tsao CW, Aday AW, Almarzooq ZI, Alonso A, Beaton AZ, Bittencourt MS, Boehme AK, Buxton AE, Carson AP, Commodore-Mensah Y et al. Heart Disease and Stroke Statistics-2022 Update: A Report From the American Heart Association. Circulation. 2022;145(8):e153–e639. [DOI] [PubMed] [Google Scholar]
- 27.Weston SJ, Hill PL, Jackson JJ. Personality traits predict the onset of disease. Soc Psychol Personal Sci. 2015. ; 6(3) : 309–317 [Google Scholar]
- 28.Zimprich D, Allemand M, Lachman ME. Factorial structure and age-related psychometrics of the MIDUS personality adjective items across the life span. Psychol Assess 2012; 24(1) : 173–186. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 29.John OP, Donahue EM, Kentle RL. The Big Five Inventory—Versions 4a and 54. Berkeley, CA: Institute of Personality and Social Research, University of California, 1991. [Google Scholar]
- 30.Goldberg LR, Johnson JA, Eber HW, Hogan R, Ashton MC, Cloninger CR, Gough HG. The international personality item pool and the future of public-domain personality measures. J Res Pers. 2006, 40(1): 84–96. [Google Scholar]
- 31.van den Berg SM, de Moor MH, McGue M, Pettersson E, Terracciano A, Verweij KJ, Amin N, Derringer J, Esko T, van Grootheest G et al. Harmonization of Neuroticism and Extraversion phenotypes across inventories and cohorts in the Genetics of Personality Consortium: an application of Item Response Theory. Behav Genet. 2014;44(4):295–313. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 32.Dawood FZ, Judd S, Howard VJ, Limdi NA, Meschia JF, Cushman M, Howard G, Herrington DM, Soliman EZ. High-Sensitivity C-Reactive Protein and Risk of Stroke in Atrial Fibrillation (from the Reasons for Geographic and Racial Differences in Stroke Study). Am J Cardiol. 2016;118(12):1826–1830. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 33.Leger KA, Turiano NA, Bowling W, Burris JL, Almeida DM. Personality Traits Predict Long-Term Physical Health via Affect Reactivity to Daily Stressors. Psychol Sci. 2021;32(5):755–765. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 34.Jokela M, Elovainio M, Nyberg ST, Tabák AG, Hintsa T, Batty GD, Kivimäki M. Personality and risk of diabetes in adults: pooled analysis of 5 cohort studies. Health Psychol. 2014;33(12):1618–21. [DOI] [PubMed] [Google Scholar]
- 35.Terracciano A, Strait J, Scuteri A, Meirelles O, Sutin AR, Tarasov K, Ding J, Marongiu M, Orru M, Pilia MG et al. Personality traits and circadian blood pressure patterns: a 7-year prospective study. Psychosom Med. 2014;76(3):237–43. [DOI] [PMC free article] [PubMed] [Google Scholar]
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