Abstract
Child bearing at an early age and prenatal cytogenetic diagnosis in pregnant women of advanced age, combined with selective abortion, make it possible to avoid the birth of many children with serious chromosomal anomalies. To see how many of such births were still avoidable in Europe, data from 16 regional EUROCAT registers of congenital anomalies in nine EEC countries were analysed. In the period 1979-1982 about 30% of children with unbalanced anomalies of autosomes were born (live- and still-births) to mothers over 35 years of age. This amounts to an estimated 1300 cases yearly in the entire population of the nine countries. The approach shows the possible use of registry data for monitoring effects of avoidance strategies.
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Selected References
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- Adams M. M., Finley S., Hansen H., Jahiel R. I., Oakley G. P., Jr, Sanger W., Wells G., Wertelecki W. Utilization of prenatal genetic diagnosis in women 35 years of age and older in the United States, 1977 to 1978. Am J Obstet Gynecol. 1981 Mar 15;139(6):673–677. doi: 10.1016/0002-9378(81)90483-x. [DOI] [PubMed] [Google Scholar]
- Baird P. A., Sadovnick A. D., McGillivray B. C. Temporal changes in the utilization of amniocentesis for prenatal diagnosis by women of advanced maternal age, 1976-1983. Prenat Diagn. 1985 May-Jun;5(3):191–198. doi: 10.1002/pd.1970050305. [DOI] [PubMed] [Google Scholar]
- Bell J. A., Pearn J., Cohen G., Ford J., Halliday J., Martin N., Mulcahy M., Purvis-Smith S., Sutherland G. Utilization of prenatal cytogenetic diagnosis in women of advanced maternal age in Australia, 1979-1982. Prenat Diagn. 1985 Jan-Feb;5(1):53–58. doi: 10.1002/pd.1970050110. [DOI] [PubMed] [Google Scholar]
- Ferguson-Smith M. A. Prenatal chromosome analysis and its impact on the birth incidence of chromosome disorders. Br Med Bull. 1983 Oct;39(4):355–364. doi: 10.1093/oxfordjournals.bmb.a071848. [DOI] [PubMed] [Google Scholar]
- Ferguson-Smith M. A., Yates J. R. Maternal age specific rates for chromosome aberrations and factors influencing them: report of a collaborative european study on 52 965 amniocenteses. Prenat Diagn. 1984 Spring;4(Spec No):5–44. doi: 10.1002/pd.1970040704. [DOI] [PubMed] [Google Scholar]
- Hassold T., Chiu D. Maternal age-specific rates of numerical chromosome abnormalities with special reference to trisomy. Hum Genet. 1985;70(1):11–17. doi: 10.1007/BF00389450. [DOI] [PubMed] [Google Scholar]
- Hook E. B., Schreinemachers D. M. Trends in utilization of prenatal cytogenetic diagnosis by New York State residents in 1979 and 1980. Am J Public Health. 1983 Feb;73(2):198–202. doi: 10.2105/ajph.73.2.198. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Jacobson C. B., Barter R. H. Intrauterine diagnosis and management of genetic defects. Am J Obstet Gynecol. 1967 Nov 15;99(6):796–807. doi: 10.1016/0002-9378(67)90395-x. [DOI] [PubMed] [Google Scholar]
- Mikkelsen M., Fischer G., Hansen J., Pilgaard B., Nielsen J. The impact of legal termination of pregnancy and of prenatal diagnosis on the birth prevalence of Down syndrome in Denmark. Ann Hum Genet. 1983 May;47(Pt 2):123–131. doi: 10.1111/j.1469-1809.1983.tb00979.x. [DOI] [PubMed] [Google Scholar]
- Simoni G., Gimelli G., Cuoco C., Romitti L., Terzoli G., Guerneri S., Rossella F., Pescetto L., Pezzolo A., Porta S. First trimester fetal karyotyping: one thousand diagnoses. Hum Genet. 1986 Mar;72(3):203–209. doi: 10.1007/BF00291878. [DOI] [PubMed] [Google Scholar]
- Steele M. W., Breg W. R., Jr Chromosome analysis of human amniotic-fluid cells. Lancet. 1966 Feb 19;1(7434):383–385. doi: 10.1016/s0140-6736(66)91387-0. [DOI] [PubMed] [Google Scholar]