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. 1989 Mar;43(1):43–47. doi: 10.1136/jech.43.1.43

The incidence of cancer in schizophrenic patients.

P B Mortensen 1
PMCID: PMC1052789  PMID: 2592890

Abstract

A cohort of 6168 schizophrenic patients was followed from 1957 to 1984 to determine the incidence of cancer in these patients. In the male schizophrenic patients the incidence of cancer was found to be significantly reduced in comparison with the general Danish population. This reduction was especially marked for cancer in the respiratory system, cancer of the prostate and cancer of the bladder. In the female patients the overall incidence of cancer did not differ from that of the general Danish population, but there was an increased risk of cancer of the digestive tract, especially cancer of the pancreas and a slight increase of the risk of breast cancer. In the female patients the risk of respiratory cancers and cancer of the female genital organs, especially cancer of the uterine cervix, was reduced. These alterations of the incidence of cancer in schizophrenic patients cannot be ascribed to differences in diagnostic accuracy. As a possible explanation of these findings a reduced exposure to well known carcinogens such as cigarette smoke may be relevant. We speculate that exposure to neuroleptics such as phenothiazines and reserpine may also be part of the explanation for the findings.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Andersen T. F. Genanvendelse af historiske datamaterialer. Nogle erfaringer med reidentifikation af et tredive år gammelt materiale. Ugeskr Laeger. 1980 Apr 20;142(16):1054–1058. [PubMed] [Google Scholar]
  2. Armstrong B., Stevens N., Doll R. Retrospective study of the association between use of rauwolfia derivatives and breast cancer in English women. Lancet. 1974 Sep 21;2(7882):672–675. doi: 10.1016/s0140-6736(74)93258-9. [DOI] [PubMed] [Google Scholar]
  3. Driscoll J. S., Melnick N. R., Quinn F. R., Lomax N., Davignon J. P., Ing R., Abott B. J., Congleton G., Dudeck L. Psychotropic drugs as potential antitumor agents: a selective screening study. Cancer Treat Rep. 1978 Jan;62(1):45–74. [PubMed] [Google Scholar]
  4. HERRIDGE C. F. Physical disorders in psychiatric illness. A study of 209 consecutive admissions. Lancet. 1960 Oct 29;2(7157):949–951. doi: 10.1016/s0140-6736(60)92025-0. [DOI] [PubMed] [Google Scholar]
  5. Hall R. C., Beresford T. P., Gardner E. R., Popkin M. K. The medical care of psychiatric patients. Hosp Community Psychiatry. 1982 Jan;33(1):25–34. doi: 10.1176/ps.33.1.25. [DOI] [PubMed] [Google Scholar]
  6. Hall R. C., Gardner E. R., Popkin M. K., Lecann A. F., Stickney S. K. Unrecognized physical illness prompting psychiatric admission: a prospective study. Am J Psychiatry. 1981 May;138(5):629–635. doi: 10.1176/ajp.138.5.629. [DOI] [PubMed] [Google Scholar]
  7. Hall R. C., Popkin M. K., Devaul R. A., Faillace L. A., Stickney S. K. Physical illness presenting as psychiatric disease. Arch Gen Psychiatry. 1978 Nov;35(11):1315–1320. doi: 10.1001/archpsyc.1978.01770350041003. [DOI] [PubMed] [Google Scholar]
  8. Heinonen O. P., Shapiro S., Tuominen L., Turunen M. I. Reserpine use in relation to breast cancer. Lancet. 1974 Sep 21;2(7882):675–677. doi: 10.1016/s0140-6736(74)93259-0. [DOI] [PubMed] [Google Scholar]
  9. Herrman H. E., Baldwin J. A., Christie D. A record-linkage study of mortality and general hospital discharge in patients diagnosed as schizophrenic. Psychol Med. 1983 Aug;13(3):581–593. doi: 10.1017/s0033291700048005. [DOI] [PubMed] [Google Scholar]
  10. Johnson D. A. The evaluation of routine physical examination in psychiatric cases. Practitioner. 1968 May;200(199):686–691. [PubMed] [Google Scholar]
  11. Kanhouwa S., Gowdy J. M., Solomon J. D. Phenothiazines and breast cancer. J Natl Med Assoc. 1984 Aug;76(8):785–788. [PMC free article] [PubMed] [Google Scholar]
  12. Katz J., Kunofsky S., Patton R. E., Allaway N. C. Cancer mortality among patients in New York mental hospitals. Cancer. 1967 Dec;20(12):2194–2199. doi: 10.1002/1097-0142(196712)20:12<2194::aid-cncr2820201220>3.0.co;2-m. [DOI] [PubMed] [Google Scholar]
  13. Laska E. M., Siegel C., Meisner M., Fischer S., Wanderling J. Matched-pairs study of reserpine use and breast cancer. Lancet. 1975 Aug 16;2(7929):296–300. doi: 10.1016/s0140-6736(75)92731-2. [DOI] [PubMed] [Google Scholar]
  14. Mack T. M., Henderson B. E., Gerkins V. R., Arthur M., Baptista J., Pike M. C. Reserpine and breast cancer in a retirement community. N Engl J Med. 1975 Jun 26;292(26):1366–1371. doi: 10.1056/NEJM197506262922603. [DOI] [PubMed] [Google Scholar]
  15. Masterson E., O'Shea B. Smoking and malignancy in schizophrenia. Br J Psychiatry. 1984 Oct;145:429–432. doi: 10.1192/bjp.145.4.429. [DOI] [PubMed] [Google Scholar]
  16. Mortensen P. B. Cancerdiagnostik og autopsifrekvens blandt skizofrene patienter. Ugeskr Laeger. 1987 Jul 13;149(29):1973–1975. [PubMed] [Google Scholar]
  17. Mortensen P. B. Neuroleptic treatment and other factors modifying cancer risk in schizophrenic patients. Acta Psychiatr Scand. 1987 Jun;75(6):585–590. doi: 10.1111/j.1600-0447.1987.tb02839.x. [DOI] [PubMed] [Google Scholar]
  18. O'Fallon W. M., Labarthe D. R., Kurland L. T. Rauwolfia derivatives and breast cancer. A case/control study in Olmsted County, Minnesota. Lancet. 1975 Aug 16;2(7929):292–296. doi: 10.1016/s0140-6736(75)92730-0. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Osterlind A., Jensen O. M. Evaluering af cancerregistreringen i Danmark 1977. En praeliminaer evaluering af cancerregisterets og landspatientregisterets registrering af cancertilfaelde. Ugeskr Laeger. 1985 Jul 29;147(31):2483–2488. [PubMed] [Google Scholar]
  20. Pamukcu A. M., Wattenberg L. W., Price J. M., Bryan G. T. Phenothiazine inhibition of intestinal and urinary bladder tumors induced in rats by bracken fern. J Natl Cancer Inst. 1971 Jul;47(1):155–159. [PubMed] [Google Scholar]
  21. Rotkin I. D. A comparison review of key epidemiological studies in cervical cancer related to current searches for transmissible agents. Cancer Res. 1973 Jun;33(6):1353–1367. [PubMed] [Google Scholar]
  22. Saugstad L. F., Odegård O. Mortality in psychiatric hospitals in Norway 1950--74. Acta Psychiatr Scand. 1979 Apr;59(4):431–447. doi: 10.1111/j.1600-0447.1979.tb04485.x. [DOI] [PubMed] [Google Scholar]
  23. Schyve P. M., Smithline F., Meltzer H. Y. Neuroleptic-induced prolactin level elevation and breast cancer: an emerging clinical issue. Arch Gen Psychiatry. 1978 Nov;35(11):1291–1301. doi: 10.1001/archpsyc.1978.01770350017001. [DOI] [PubMed] [Google Scholar]
  24. du Pan R. M., Müller C. La mortalité par cancer chez les patients psychiatriques hospitalisés. Schweiz Med Wochenschr. 1977 Apr 30;107(17):597–604. [PubMed] [Google Scholar]

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