Figure 5.

GILZ PEP-1 peptide treatment reduces the clinical signs of colitis in IL-10KO mice. After an intraperitoneal injection of PEP-1, or scrambled sequence (control) at week 7, mice were monitored daily for 6 weeks, and the percentage of body weight loss (A) was reported. Graph of total score disease (B) was documented, taking into consideration the stool consistency and rectal bleeding. Following the sixth week, mice were sacrificed to calculate the ratio between weight and length of the colon (C). Graphs represent mean ± SEM. * p < 0.05, ** p < 0.005. p-values were calculated using the unpaired Student’s t-test. Each dot represents an individual mouse (n = 8/group).