Table 3.
Intra-articular application of hyaluronic acid (HA) in osteoarthritis (OA) and its findings.
| Study | Design | Participants | Intervention | Findings | References |
|---|---|---|---|---|---|
| Altman et al. (2004) | Randomized, double-blind, placebo-controlled trial | 495 patients with knee OA | HA injections (3 weekly injections) vs. placebo | HA group showed significant improvement in pain and function compared to placebo | [126] |
| Bannuru et al. (2009) | Meta-analysis | 29 randomized controlled trials | HA injections vs. control interventions (placebo, saline, or NSAIDs) | HA injections were superior to control interventions in reducing pain and improving function in knee OA | [127] |
| Rutjes et al. (2012) | Systematic review and meta-analysis | 76 randomized controlled trials | HA injections vs. control interventions (placebo or no treatment) | HA injections provided significant pain relief and functional improvement compared to control interventions in knee OA | [128] |
| Filardo et al. (2015) | Randomized controlled trial | 160 patients with knee OA | HA injections vs. platelet-rich plasma (PRP) injections | HA and PRP injections showed similar efficacy in reducing pain and improving function in knee osteoarthritis | [45] |
| Bannuru et al. (2015) | Systematic review and meta-analysis | 137 randomized controlled trials | Various HA preparations vs. control interventions (placebo, saline, or corticosteroids) | HA injections were effective in reducing pain and improving function in knee OA with a favourable safety profile | [129] |
Selected clinical studies on the use of intraarticular HA injections in OA. This is not an exhaustive list, and further research and clinical trials have been conducted in this field. For more detailed information, it is recommended to refer to the referenced papers.