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Caspase-3 and -8, Bax, and Bcl-2 levels for compounds 21, 28, and 30 and Staurosporine on a human epithelial cancer cell line (A-594).
| Compd. No. | Caspase-3 | Caspase-8 | Bax | Bcl-2 | ||||
|---|---|---|---|---|---|---|---|---|
| Conc (Pg/mL) | Fold Change | Conc (ng/mL) | Fold Change | Conc (Pg/mL) | Fold Change | Conc (ng/mL) | Fold Reduction | |
| 21 | 530 ± 5 | 8 | ND | ND | ND | ND | ND | ND |
| 28 | 595 ± 5 | 9 | 2.25 | 25 | 325 | 36 | 0.80 | 6 |
| 30 | 710 ± 6 | 11 | 2.50 | 28 | 345 | 38 | 0.65 | 8 |
| Staurosporine | 465 ± 4 | 7 | 1.85 | 21 | 288 | 32 | 1.00 | 5 |
| Control | 65 | 1 | 0.09 | 1 | 9 | 1 | 5.00 | 1 |
ND: Not Determined.
