Author Correction: Synthetic Tet-inducible artificial microRNAs targeting β-catenin or HIF-1α inhibit malignant phenotypes of bladder cancer cells T24 and 5637

Correction to: Scientific Reports 10.1038/srep16177, published online 6 November 2015

The original Article contains errors. In Figure 3E the EDU and DAPI images of HIF-1a (Dox+) group are incorrect. The Authors discovered that incorrect images were used for this condition. The corrected Figure 3 and accompanying legend appear below as Figure 1:

Figure 1.

The effects of Tet-inducible artificial microRNAs on cell proliferation in bladder cancer cells. The growth curves of T24/5637 cells treated with “amiRNA β-catenin” (A,B) or “amiRNA HIF-1α” (C,D) induced by doxycycline were determined using CCK-8 assay. Data are shown as mean ± SD. The proliferation of T24 (E) and 5637 (F) treated with “amiRNA β-catenin” or “amiRNA HIF-1α” induced by doxycycline were also determined using EdU incorporation assay.

In Figure 4C the condition beta-catenin (Dox+) is partially overlapping with the condition HF-1alpha(Dox+). The corrected Figure 4 and accompanying legend appear below as Figure 2:

Figure 2.

The effects of Tet-inducible artificial microRNAs on cell apoptosis in bladder cancer cells. The relative activity of caspase-3 was calculated in T24/5637 cells treated with “amiRNA β-catenin” (A,B) or “amiRNA HIF-1α” (A,B) induced by doxycycline using ELISA assay. The apoptotic cells were observed and calculated in T24/5637 cells treated with “amiRNA β-catenin” (C–F) or “amiRNA HIF-1α” (C–F) induced by doxycycline using Hoechst 33,258 staining assay. Data are shown as mean ± SD.

In Figure 5B the conditions beta-catenin (Dox−) (bottom image) and NC (Dox+) (bottom image) seem to be very similar. In Figure 5B the conditions NC (Dox−) (top image) and NC (Dox+) (top image) are partially overlapping. The corrected Figure 5 and accompanying legend appear below as Figure 3:

Figure 3.

The effects of Tet-inducible artificial microRNAs on cell migration in bladder cancer cells. The relative rate of cell migration was calculated in T24 (A) and 5637 (B) cells treated with “amiRNA β-catenin” or “amiRNA HIF-1α” induced by doxycycline using wound-healing assay. Data are shown as mean ± SD.