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[Preprint]. 2023 Sep 21:2023.09.21.558875. [Version 1] doi: 10.1101/2023.09.21.558875

Figure 4. The inflammasome is protective during DENV infection.

Figure 4.

(A-B) Survival curves (A) and weight loss over time (B) of Casp1/11+/+Ifnar −/− (Caspase 1/11 WT), Casp1/11 +/−Ifnar −/− (Caspase 1/11 Het), or Casp1/11 −/−Ifnar −/− (Caspase 1/11 KO) littermates infected intravenously with 3 x 105 PFU of DENV2 D220. Survival was monitored over 14 days. Weight loss was monitored over 9 days. Numbers in parentheses indicate the numbers of mice in each group. **p<0.01. Statistical significance was determined by Mantel–Cox log-rank test (A) or two-way ANOVA with Holm-Sidak’s multiple comparisons test (B). (C-D) Survival curves of Nlrp3 +/+Ifnar −/− (NLRP3 WT), Nlrp3 +−/Ifnar −/− (NLRP3 Het), or Nlrp3 −/−Ifnar −/− (NLRP3 KO) littermates infected intravenously with a 5 x 105 PFU (High Dose) (C) or 7.5 x 104 PFU (Low Dose) (D) of DENV2 D220 and monitored over 10 days. Numbers in parentheses indicate the numbers of mice in each group.