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. 1988 Apr;86(4):1104–1107. doi: 10.1104/pp.86.4.1104

β-Glucoside Activators of Mung Bean UDP-Glucose: β-Glucan Synthase 1

II. Comparison of Effects of an Endogenous β-Linked Glucolipid with Synthetic n-Alkyl β-d-Monoglucopyranosides

Theresa Callaghan 1,2, Peter Ross 1, Patricia Weinberger-Ohana 1, Moshe Benziman 1
PMCID: PMC1054635  PMID: 16666039

Abstract

n-Alkyl (C6-C12) β-d-monoglucopyranosides have been found to be highly potent activators of mung bean β-glucan synthase in vitro, increasing the Vmax of the enzyme as much as 60-fold and with Ka values as low as 10 micromolar. Activation is highly specific for the β-linked terminal glucose residue; other alkyl glycosides such as, octyl-α-glucoside, dodecyl β-maltoside, 6-lauryl sucrose, 6-lauryl glucose, which lack this structure, are ineffective as activators. Based on the similarities in their structure and effects on β-glucan synthesis under a variety of conditions, it is proposed that the alkyl β-glucosides are structural analogs of the native glucolipid activator of β-glucan synthase isolated from mung bean extracts.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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