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. 2023 Oct 5;12(1):2261326. doi: 10.1080/2162402X.2023.2261326

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© 2023 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.

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Figure 5. — IL-17A and IL-17F distinctly modulates the expression of target and tumor progression genes in different tumor types in vitro.

IL-17A or IL-17F (200 ng/mL) were added to cultured B16.SIY (melanoma), MC57.SIY (fibrosarcoma), EL4.SIY (lymphoma), and C1498.SIY (leukemia) cells in serum-reduced conditions. (a) Concentration of CXCL1 measured in 48 h culture supernatants. (B) Relative amounts of Csf1 and Saa3 mRNA determined after 24 h of stimulation by RT-qPCR. (c) Heat maps summarizing the relative levels of Hif1a, Vegf, Mmp2, Mmp9, Fgf, Pdl1, E-cadherin (Cdh1), and N-cadherin (Cdh2) transcripts after 24 h of stimulation. Transcript amounts were normalized to 18S and medium transcript levels. P value calculated with One-way ANOVA. *p < .05; **p < .01; ***p < .001; ****p < .0001. (d) Scatter plot of tumor cell lines along the two principal components (54% of variance) obtained after principal component analysis of tumor cell lines according to the variables depicted in Figure 5a–5 and Supplementary Figure S4.