Skip to main content
NCBI home page
Plant Physiology logoLink to Plant Physiology
. 1986 Oct;82(2):619–621. doi: 10.1104/pp.82.2.619

Effects of Fructose 2,6-Bisphosphate on Phosphoglucomutase from Plants 1

Miquel Carreras 1, Ramon Bartrons 1, Fernando Climent 1, José Carreras 1
PMCID: PMC1056172  PMID: 16665081

Abstract

Fructose 2,6-bisphosphate affects phosphoglucomutase from plant and animal sources in a similar way. As previously found with rabbit muscle phosphoglucomutase, fructose 2,6-bisphosphate cannot substitute for glucose 1,6-bisphosphate as a cofactor in the reaction catalyzed by phosphoglucomutase from potato tubers, pea seeds, and string-beans. In the presence of glucose 1,6-bisphosphate, fructose 2,6-bisphosphate inhibits phosphoglucomutase from potato tubers. Activation of phosphoglucomutase from plant sources by fructose 2,6-bisphosphate reported by others was probably due to contamination of the commercial preparation of fructose 2,6-bisphosphate by glucose 1,6-bisphosphate.

Full text

PDF
619

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Alpers J. B. Studies on phosphomutases. II. Effects of 1,3-diphosphoglycerate on phosphoglucomutase. J Biol Chem. 1968 Apr 25;243(8):1698–1704. [PubMed] [Google Scholar]
  2. Bartrons R., Carreras M., Climent F., Carreras J. Inhibition of phosphoglucomutase by fructose 2,6-bisphosphate. Biochim Biophys Acta. 1985 Sep 27;842(1):52–55. doi: 10.1016/0304-4165(85)90292-2. [DOI] [PubMed] [Google Scholar]
  3. Galloway C. M., Dugger W. M., Black C. C. In vitro activation of phosphoglucomutase by fructose 2,6-bisphosphate. Plant Physiol. 1985 Nov;79(3):920–922. doi: 10.1104/pp.79.3.920. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Lowry O. H., Passonneau J. V. Phosphoglucomutase kinetics with the phosphates of fructose, glucose, mannose, ribose, and galactose. J Biol Chem. 1969 Feb 10;244(3):910–916. [PubMed] [Google Scholar]
  5. MCGILVERY R. W., MOKRASCH L. C. Purification and properties of fructose-1, 6-diphosphatase. J Biol Chem. 1956 Aug;221(2):909–917. [PubMed] [Google Scholar]
  6. Mulhausen H., Mendicino J. A kinetic study of the effect of alpha-D-galactose, alpha-D-mannose, alpha-D-glucosamine, N-acetyl-alpha-D-glucosamine, and alpha-D-ribose diphosphate on the activity of phosphoglucomutase. J Biol Chem. 1970 Aug 25;245(16):4038–4046. [PubMed] [Google Scholar]
  7. Ray W. J., Jr, Roscelli G. A. Activation and inhibition in the phosphoglucomutase system. J Biol Chem. 1966 Jun 10;241(11):2596–2602. [PubMed] [Google Scholar]
  8. Rose I. A., Warms J. V., Kaklij G. A specific enzyme for glucose 1,6-bisphosphate synthesis. J Biol Chem. 1975 May 10;250(9):3466–3470. [PubMed] [Google Scholar]
  9. Takamiya S., Fukui T. Phosphoglucomutase from potato tubers. Chemical and catalytic properties. J Biochem. 1978 Sep;84(3):569–574. doi: 10.1093/oxfordjournals.jbchem.a132161. [DOI] [PubMed] [Google Scholar]
  10. Van Schaftingen E., Lederer B., Bartrons R., Hers H. G. A kinetic study of pyrophosphate: fructose-6-phosphate phosphotransferase from potato tubers. Application to a microassay of fructose 2,6-bisphosphate. Eur J Biochem. 1982 Dec;129(1):191–195. doi: 10.1111/j.1432-1033.1982.tb07039.x. [DOI] [PubMed] [Google Scholar]

Articles from Plant Physiology are provided here courtesy of Oxford University Press

RESOURCES