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Journal of Experimental & Clinical Cancer Research : CR logoLink to Journal of Experimental & Clinical Cancer Research : CR
. 2023 Oct 14;42:266. doi: 10.1186/s13046-023-02852-5

Correction: Osteopontin alters DNA methylation through up-regulating DNMT1 and sensitizes CD133+/CD44 + cancer stem cells to 5 azacytidine in hepatocellular carcinoma

Xiaomei Gao 1,#, Yuanyuan Sheng 1,#, Jing Yang 1,#, Chaoqun Wang 1, Rui Zhang 1, Ying Zhu 1, Ze Zhang 1, Kaili Zhang 1, Shican Yan 1, Haoting Sun 1, Jinwang Wei 1, Xuan Wang 1, Xinxin Yu 1, Yu Zhang 1, Qin Luo 1, Yan Zheng 1, Peng Qiao 1, Yue Zhao 2, Qiongzhu Dong 1,, Lunxiu Qin 1,
PMCID: PMC10576341  PMID: 37838668

Correction: J Exp Clin Cancer Res 37, 179 (2018)

10.1186/s13046-018-0832-1

Following publication of the original article [1], errors were found in Fig. 5a due to misused of images in Hep3B-SCR/EV, -shOPN/EV, and -shOPN/DNMT1.

Fig. 5.

Fig. 5

OPN modulates the properties of CD133+/CD44 + cells through regulating DNMT1. a When CD133+/CD44 + cells with shOPN were transfected with DNMT1 from Huh7 and Hep3B cells, the ability of sphere forming was rescued compared to the shOPN group, 40X. b The expression of indicated genes down regulated in CD133+/CD44 + cells from Huh7 and Hep3B transfected with shOPN compared to the control, were reversed in part by DNMT1 transfection. c The number of spheres formed by CD133+/CD44 + cells with EV, CD133+/CD44 + cells with OPN and CD133+/CD44 + cells with OPN treated by 5 Aza, **, p < 0.01, ***, p < 0.001. d The number of spheres formed by CD133+/CD44 + cells with EV/SCR, CD133+/CD44 + cells with OPN/SCR and CD133+/CD44 + cells with OPN/shDNMT1, **, p < 0.01. e CD133+/CD44 + SCR/EV, CD133+/CD44 + shOPN/EV and CD133+/CD44 + cells shOPN/DNMT1 from Huh7 were injected subcutaneously into the mice, and recorded the time of tumor initiation, tumor weight and tumor volume, **, p < 0.01, ***, p < 0.001, NS, no significance. f IHC staining of stemness-related markers, OCT4 and Nanog in the tumor tissues derived from CD133+/CD44 + cells with SCR/EV or shOPN/EV or shOPN/DNMT1

The correct figure is given below:

Footnotes

The online version of the original article can be found at 10.1186/s13046-018-0832-1.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Xiaomei Gao, Yuanyuan Sheng and Jing Yang contributed equally to this work.

Contributor Information

Qiongzhu Dong, Email: qiongzhudong@163.com, Email: qzhdong@fudan.edu.cn.

Lunxiu Qin, Email: qinlx@fudan.edu.cn.

References

  • 1.Gao X, Sheng Y, Yang J, et al. Osteopontin alters DNA methylation through up-regulating DNMT1 and sensitizes CD133+/CD44 + cancer stem cells to 5 azacytidine in hepatocellular carcinoma. J Exp Clin Cancer Res. 2018;37:179. 10.1186/s13046-018-0832-1. [DOI] [PMC free article] [PubMed]

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