Abstract
The method used to produce “Connaught” tuberculin purified protein derivative (PPD) is described. The tuberculin PPD for the multiple-puncture method was shown to be stable for at least 24 months at 5 C; tuberculin PPD for the intracutaneous method was shown to be stable at 5 C and 24 C for a period of 18 months in the presence of Tween 80. Evans blue or brillant vital red was added to tuberculin PPD for improved testing by the multiple-puncture method. These tinted tuberculin preparations were found to be as stable as the Connaught tuberculin PPD preparations without dye at 5 C. Freeze-dried tuberculin PPD with Plasdone as an inert base was found to be remarkably stable for a period of at least 24 months at 5, 24, and 37 C.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- LONG D. A., MILES A. A., PERRY W. L. The assay of tuberculin. Bull World Health Organ. 1954;10(6):989–1002. [PMC free article] [PubMed] [Google Scholar]
- MAGNUSSON M., GULD J., MAGNUS K., WAALER H. Diluents for stabilization of tuberculin. Bull World Health Organ. 1958;19(5):799–828. [PMC free article] [PubMed] [Google Scholar]