Systematic review of ceftaroline fosamil in the management of patients with methicillin-resistant Staphylococcus aureus pneumonia

Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) is responsible for an array of problematic community- and healthcare-acquired infections, including pneumonia, and is frequently associated with severe disease and high mortality rates. Standard recommended treatments for empiric and targeted coverage of suspected MRSA in patients with community-acquired pneumonia (CAP) and hospital-acquired pneumonia (HAP), including ventilator-associated pneumonia (VAP), are vancomycin and linezolid. However, adverse events such as acute kidney injury and Clostridium difficile infection have been associated with these antibiotics. Ceftaroline fosamil is a β-lactam/extended-spectrum cephalosporin approved for the treatment of adults and children with CAP and complicated skin and soft tissue infections. Ceftaroline has in vitro activity against a range of common Gram-positive bacteria and is distinct among the β-lactams in retaining activity against MRSA. Due to the design of the pivotal randomised controlled trials of ceftaroline fosamil, outcomes in patients with MRSA CAP were not evaluated. However, various reports of real-world outcomes with ceftaroline fosamil for pneumonia caused by MRSA, including CAP and HAP/VAP, been published since its approval. A systematic literature review and qualitative analysis of relevant publications was undertaken to collate and summarise relevant published data on the efficacy and safety of ceftaroline fosamil in patients with MRSA pneumonia. While relatively few real-world outcomes studies are available, the available data suggest that ceftaroline fosamil is a possible alternative to linezolid and vancomycin for MRSA pneumonia. Specific scenarios in which ceftaroline fosamil might be considered include bacteraemia and complicating factors such as empyema.

Tweetable abstract

Ceftaroline fosamil has an established clinical profile for treatment of community-acquired pneumonia. While RCT data in patients with MRSA pneumonia are lacking, studies suggest ceftaroline fosamil is a possible alternative to linezolid and vancomycin. https://bit.ly/44F4Gzw

Introduction

Staphylococcus aureus is a ubiquitous commensal and opportunistic Gram-positive bacterial pathogen. It is responsible for numerous community- and hospital-acquired infections, including bloodstream, respiratory, skin and soft tissue, and cardiac valve and device/prosthetic infections, which range in severity from mild to potentially life threatening [1–3]. Methicillin-resistant S. aureus (MRSA) constitute a group of S. aureus strains that have developed resistance to β-lactam antibiotics (a cornerstone of treatment for a range of infections, including many of those caused by methicillin-susceptible S. aureus (MSSA)) and in many cases to various other antimicrobial classes (some MRSA are also classed as multidrug resistant (MDR)) [4, 5]. Some variants of S. aureus express virulence factors that adversely influence host responses to infection and the species can form biofilms that are difficult to eradicate, complicating the course of treatment [3, 6, 7].

Although S. aureus accounts for a small proportion of all bacterial causes of pneumonia (∼3–5%), MRSA pneumonia, whether originating in community (community-acquired pneumonia (CAP)) or hospital/healthcare (hospital-acquired pneumonia (HAP)) settings and/or associated with intubation and mechanical ventilation (ventilator-associated pneumonia (VAP)), is typically severe and frequently fatal [8–10]. MRSA pneumonia can arise as primary or secondary to another infectious source, and is more common in vulnerable/frail patients and those with chronic comorbidities. Antimicrobial usage and reported resistance rates have increased worldwide since the start of the severe acute respiratory syndrome coronavirus 2 pandemic [11–14] and MRSA has been reported to be among the most frequent pulmonary bacterial co-infections in patients with coronavirus disease 2019 [15].

Ceftaroline fosamil is a broad-spectrum cephalosporin with in vitro activity against a range of common CAP pathogens, including MSSA, MRSA, Streptococcus pneumoniae and non-β-lactamase-producing Enterobacterales [16]. It has an established clinical profile in adults and children with CAP and complicated skin and soft tissue infections (cSSTIs) [17–24]. Ceftaroline fosamil has been shown to be superior to ceftriaxone, a standard-of-care treatment, in a meta-analysis of three randomised controlled trials (RCTs) in adults with (non-MRSA) CAP [25]. Various reports of real-world outcomes with ceftaroline fosamil for pneumonia caused by MRSA have been published since its approval. A systematic literature review and qualitative analysis of relevant publications was undertaken to collate and summarise relevant published data.

Management strategies for MRSA pneumonia

The most frequent symptoms of pneumonia include fever, cough, chest pain and dyspnoea, and in severe cases complications such as acute respiratory distress syndrome, multiple organ failure and septic shock are present, which can require treatment in an intensive care unit (ICU). Management strategies for both CAP and HAP/VAP, including initial therapy selection, are guided by disease severity and risk factors for involvement of resistant pathogens based on local surveillance and susceptibility patterns [26, 27]. There is also increasing recognition of a role for rapid diagnostics in supporting treatment decisions [15, 26, 28].

International guidelines relevant to the diagnosis and management of MRSA pneumonia include recommendations for CAP from the Infectious Diseases Society of America (IDSA)/American Thoracic Society (ATS) [26, 29] and the European Respiratory Society/European Society for Clinical Microbiology and Infectious Diseases [30], and European/Latin American and US-focused guidelines for HAP/VAP [27, 31]. Antimicrobial therapy for pneumonia is typically administered empirically with the aim of de-escalation supported by microbiological culture data [31]. Rapid selection and initiation of optimal empiric therapy for any given patient is a key clinical judgement; delayed and/or inadequate empiric therapy is associated with adverse clinical outcomes, including increased rates of treatment failure and mortality and increased healthcare costs [32]. Initial therapy selection for pneumonia is therefore guided by patient risk assessment and local/regional resistance patterns [26, 27, 31].

As MRSA requires different antimicrobial coverage to the standard treatments for CAP and HAP/VAP, there is a need to quickly determine the risk of MRSA involvement so that coverage for MRSA can be included in empiric therapy if required. While various risk evaluation strategies have been evaluated, the “PES” score (denoting Pseudomonas aeruginosa, extended-spectrum β-lactamase-producing Enterobacterales and MRSA) is recommended to guide empiric coverage of these problem pathogens [33, 34].

For patients with CAP, clinical features at admission suggestive of suspected S. aureus involvement include concurrent influenza infection, haemoptysis, multilobar infiltrates and neutropenia [2, 35]. Prior isolation of MRSA from a respiratory sample is considered a risk factor for MRSA which should prompt the inclusion of anti-MRSA coverage in the initial antimicrobial treatment regimen [26]. Severe CAP according to the IDSA/ATS guidelines is defined by the presence of two major criteria: the need for invasive mechanical ventilation due to severe acute respiratory failure and/or the presence of septic shock, or the presence of three or more minor criteria [36, 37]. For patients with HAP/VAP, prior antimicrobial therapy within 90 days is considered a risk factor for MRSA involvement. Other risk factors for MRSA in patients with HAP/VAP include age, onset >6 days after admittance, respiratory infection/colonisation caused by MRSA in the previous year and recent exposure to fluoroquinolone or antibiotics treating Gram-positive organisms [27, 38].

The current international HAP/VAP guidelines generally recommend linezolid or vancomycin for first-line empiric MRSA coverage [27, 31]. However, use of these agents in the empiric setting for patients with pneumonia has been associated with various adverse outcomes, including acute kidney injury, Clostridium difficile infection, and the emergence of vancomycin-resistant Enterococcus spp. and secondary Gram-negative rod detection [39]. Ceftaroline fosamil is noted as a recommended treatment for non-severe CAP (in combination with a macrolide or doxycycline) in the most recent IDSA/ATS CAP recommendations and is mentioned as a potential treatment for MRSA coverage in the most recent IDSA/ATS HAP/VAP guidance [26, 27]. Various other antimicrobial therapies for MRSA are available (some of which have potential roles in the treatment of pneumonia), including ceftobiprole (approved in some regions but not in the USA), teicoplanin, azithromycin, clindamycin, fluoroquinolones (levofloxacin and moxifloxacin) and tedizolid [7]. Daptomycin is not effective in pneumonia due to its inactivation by lung surfactant.

Limitations of vancomycin include the need for therapeutic drug monitoring (dosing adjusted based on trough serum concentrations), poor lung tissue penetration, as well as emergence of vancomycin resistance and adverse effects, including potential nephrotoxicity; there is some uncertainty if vancomycin can provide optimal treatment for MRSA pneumonia [40, 41]. Linezolid offers the potential advantage of oral as well as intravenous formulations (with potential for improving patients to be discharged earlier), but its safety profile includes risk of drug interactions with some common classes of medicines, and for patients with MRSA nosocomial pneumonia it is considered to increase the risk of thrombocytopenia and gastrointestinal events compared with the glycopeptides vancomycin and teicoplanin [42].

Ceftaroline fosamil for treatment of MRSA pneumonia

Ceftaroline fosamil is a β-lactam/extended-spectrum cephalosporin which was first commercialised in 2010 and is now approved in multiple countries worldwide for the treatment of adults and children with CAP or cSSTI, including that caused by S. aureus [43, 44]. Ceftaroline fosamil (pro-drug) is rapidly converted to active ceftaroline upon i.v. administration; two dosage regimens (“standard dose” of 600 mg every 12 h and “high dose” of 600 mg every 8 h) have been evaluated in phase II–IV clinical trials (doses are adjusted for patients with estimated creatinine clearance <50 mL·min⁻¹), with the high dose approved (excluding in the USA) for cSSTI due to MRSA with ceftaroline minimum inhibitory concentration (MIC) of 1 or 2 mg·L⁻¹ [43, 44]. The in vitro spectrum of activity of ceftaroline includes MRSA (as well as MSSA), other common Gram-positive pathogens and non-β-lactamase-producing Enterobacterales; however, due to the design of the pivotal clinical trials (specifically, the comparator ceftriaxone is not active against MRSA), efficacy was not assessed in patients with MRSA CAP [19, 20, 22, 25].

β-lactams target bacterial penicillin-binding proteins (PBPs) and thereby disrupt cell wall synthesis. In S. aureus, acquisition of an alternative PBP (PBP2) which has low affinity for most β-lactams confers methicillin resistance [6]. Unlike most β-lactams, ceftaroline targets PBP2 with high affinity [45–47], which results in activity against both MSSA and MRSA, including vancomycin-resistant variants [48]. International antimicrobial surveillance studies covering various regions from 2008 to 2020 have consistently reported that ceftaroline fosamil demonstrates potent in vitro activity against both MSSA and MRSA (including MDR) strains from patients with pneumonia, albeit with some regional variations in MRSA susceptibility (table 1).

TABLE 1.

In vitro activity of ceftaroline against Staphylococcus aureus from national and multinational surveillance studies

Region (isolates)	MIC data, mg·L−1			CLSI MIC interpretation, %			EUCAST MIC interpretation, %
	MIC50	MIC90	MIC range	S	SDD	R	S	I	R
All regions, 2012–2017 [ 71 ] #
MSSA (n=25 208)	0.25	0.25	0.015–2	>99.9	<0.01	0	>99.9	<0.01	0
MRSA (n=35 837)	0.5	2	0.015–64	89.3	10.0	0.7	89.3	10.0	0.7
USA, 2008–2010 [ 72 ] ¶
MSSA (n=4016)	0.25	0.25	≤0.008–1	100		0	NR		NR
MRSA (n=4453)	1	1	0.12–2	96.1	3.9	0	NR		NR
MDR (n=21)+	1	2	0.5–2	85.7	14.3	0	NR		NR
USA, 2010–2016 [ 73 ] §							NR		NR
MSSA (n=11 377)	0.25	0.25	NR	100		0	100		0
MRSA (n=9679)	0.5	1	NR	97.2		<0.1	97.2		2.8
USA, 2018–2020 [ 74 ] ƒ
MSSA (n=5831)	0.25	0.25	≤0.06–0.5	100		0	100		0
MRSA (n=3887)	1	1	0.12–2	93.4	6.6	0	93.4	6.6	0
China, 2018 [ 75 ] #
MSSA (n=251)	0.5	0.5	0.12–1	100		0	NR		NR
MRSA (n=155)	1	2	≤0.06–2	83.9		16.1	NR		NR
Middle East and Africa, 2015–2018 [ 76 ] ƒ
MSSA (n=313)	0.25	0.25	0.12–0.5	100		0	100		0
MRSA (n=293)	1	2	0.25–2	88.1		0	88.1		11.9

MIC: minimum inhibitory concentration; CLSI: Clinical and Laboratory Standards Institute; EUCAST: European Committee on Antimicrobial Susceptibility Testing; S: susceptible; SDD: susceptible dose-dependent; R: resistant; I: intermediate; MSSA: methicillin-susceptible S. aureus; MRSA: methicillin-resistant S. aureus; MDR: multidrug resistant; NR: not reported. Susceptibility interpretation based on ceftaroline fosamil 600 mg 12 h dosing and EUCAST MIC breakpoints for S. aureus infections other than pneumonia [50, 51]. ^#: isolates from hospitalised patients with various infection types (proportion of respiratory isolates NR); ^¶: 7.5% of isolates from patients with pneumonia; ⁺: MDR defined as resistance to oxacillin, erythromycin, clindamycin, levofloxacin, tetracycline and trimethoprim–sulfamethoxazole; ^§: 24% of isolates from patients with pneumonia; ^ƒ: all isolates from patients with lower respiratory tract infections.

Data from in vitro and in vivo studies indicate that ceftaroline is pharmacodynamically active against diverse strains of S. aureus, including MSSA and MRSA (table 2). These pre-clinical studies have established pharmacokinetic/pharmacodynamic (PK/PD) targets for ceftaroline against S. aureus, which along with population PK modelling using a large database of PK samples from the ceftaroline clinical trial programme have been used to support probability of target attainment simulations to evaluate expected efficacy against the full range of pathogen MICs likely to be encountered in clinical practice (table 3), as well as to establish interpretative criteria (breakpoints) for relevant pathogens. Importantly for the treatment of pneumonia, it has been established that ceftaroline achieves lung penetration similar to that of other β-lactams [49].

TABLE 2.

Pharmacodynamics of ceftaroline against Staphylococcus aureus: in vitro and pre-clinical studies

First author, year [ref.]	Design	Isolates	%fT required for stasis	%fT required for 1 log10 bacterial CFU reduction
Andes, 2006 [ 77, 78 ]	Mouse neutropenic thigh	3 MSSA, 1 MRSA; ceftaroline MICs: 0.12–1 mg·L−1	26±8	NR
Bhalodi, 2012 [ 79 ]	Neutropenic murine lung model, human-simulated ceftaroline fosamil regimen of 600 mg every 12 h	2 MSSA, 15 MRSA; ceftaroline MICs: 0.5–4 mg·L−1	16	41
Keel, 2011 [ 80 ]	Mouse neutropenic thigh	4 MSSA, 22 MRSA; ceftaroline MICs: 0.125–4 mg·L−1	NR	19.3
Macgowan, 2013 [ 81 ]	Single-compartment dilutional pharmacokinetic model	3 MSSA, 9 MRSA; ceftaroline MICs: 0.12–1 mg·L−1	24.5±8.9	27.8±9.5
Singh, 2017 [ 82 ]	In vitro hollow fibre infection model using every 8 h ceftaroline dosing	12 MRSA; ceftaroline MICs: 2–8 mg·L−1	28.7±6.4	31.8±5.8

CFU: colony-forming unit; fT: free drug time; MSSA: methicillin-susceptible S. aureus; MRSA: methicillin-resistant S. aureus; NR: not reported.

TABLE 3.

Pharmacodynamics of ceftaroline in pneumonia: clinical pharmacology and population pharmacokinetic (PK) modelling studies

First author, year [ref.]	Design	Subjects	Main results
Riccobene, 2016 [ 49 ]	Clinical pharmacology with lung and plasma PK sampling and PK modelling and simulation	Healthy adults (n=53)	At 600 mg every 12 h and a MIC of 1 mg·L−1, 98.1% of simulated patients were predicted to achieve fT>MIC in plasma of 42% and 81.7% were predicted to achieve fT>MIC in ELF of 17%. At 600 mg every 8 h, 100% and 95% were predicted to achieve the respective plasma and ELF targets.
Li, 2019 [ 83 ]	Population PK modelling and simulation	Overall (n=533); healthy adults (n=221); patients with cSSTI or CAP (n=312)	Race was not a significant covariate impacting ceftaroline PK, suggesting similar ceftaroline PK in Asian and Western populations. PTAs of 90–100% were predicted for Asian patients with CAP treated with ceftaroline fosamil at MIC90 values of target CAP pathogens from the Asia-Pacific region. >90% PTAs were predicted at respective EUCAST and CLSI clinical MIC breakpoints, including S. aureus.
Cristinacce, 2019 [ 84 ]	Population PK modelling and simulation	Overall (n=951); healthy adults (n=267); patients with cSSTI or CAP (n=312)	Ceftaroline fosamil demonstrated higher overall PTA rates than levofloxacin and ceftriaxone, in particular against S. aureus.

MIC: minimum inhibitory concentration; fT: free drug time; ELF: epithelial lining fluid; cSSTI: complicated skin and soft tissue infection; CAP: community-acquired pneumonia; PTA: probability of target attainment; EUCAST: European Committee on Antimicrobial Susceptibility Testing; CLSI: Clinical and Laboratory Standards Institute; S. aureus: Staphylococcus aureus.

MIC breakpoints for ceftaroline against S. aureus (including MRSA) from infections other than pneumonia have been established by the European Committee on Antimicrobial Susceptibility Testing (EUCAST) (susceptible ≤1 mg·L⁻¹; intermediate 2 mg·L⁻¹; resistant >2 mg·L⁻¹). For S. aureus from pneumonia, the respective susceptible and resistant breakpoints are ≤1 and >1 mg·L⁻¹ (EUCAST guidance notes that ceftaroline resistance in S. aureus is rare) [50]. Unlike EUCAST, the Clinical and Laboratory Standards Institute (CLSI) MIC breakpoints for ceftaroline against S. aureus (susceptible ≤1 mg·L⁻¹; susceptible dose-dependent 2–4 mg·L⁻¹; resistant ≥8 mg·L⁻¹) do not currently differentiate pneumonia versus other isolate sources [51]. The international surveillance data (table 1) indicate that ceftaroline susceptibility among MRSA, whether based on EUCAST or CLSI interpretations, remains high (albeit with some regional variability) following more than a decade of commercial availability of ceftaroline fosamil.

While it has not been evaluated in RCTs in patients with MRSA pneumonia, in three pivotal RCTs in hospitalised adults with moderate or severe (non-MRSA) CAP, ceftaroline fosamil was shown to be non-inferior to ceftriaxone [19, 20, 22], and in a meta-analysis of the three RCTs, it was found to be superior to ceftriaxone [25]. Among patients with confirmed baseline pathogens, pooled clinical response rates numerically favoured ceftaroline fosamil over ceftriaxone in various subgroups, including in patients with Gram-positive (including S. aureus and S. pneumoniae) or Gram-negative (including Escherichia coli, Haemophilus influenzae, Haemophilus parainfluenzae and Klebsiella pneumoniae) baseline pathogens and in patients with mono- or polymicrobial infections [25]. These clinical results are consistent with the drug's documented in vitro activity and PK/PD profile (tables 1–3), and collectively the data provide a strong rationale for consideration of ceftaroline fosamil as a potential treatment in MRSA pneumonia.

Literature search

Overview

A systematic literature review was performed to identify real-world studies reporting the use of ceftaroline fosamil treatment and outcomes in patients with MRSA pneumonia. Literature review and data extraction was performed in accordance with the PRISMA (Preferred Reporting Items for Systematic reviews and Meta-Analyses) 2020 statement [52]. PubMed was used as the main source database for literature searches.

Data extraction

Search results were systematically screened to obtain a list of publications to be considered for inclusion in the review. Included publications were in English language and reported data for adults with a diagnosis of pneumonia with MRSA confirmed or suspected as the causative pathogen treated with ceftaroline fosamil. All subtypes of pneumonia (e.g. CAP, HAP and VAP) were included. Publications considered suitable for inclusion included case reports/case series, observational and case–control studies, and RCTs. Literature reviews and meta-analyses were checked for relevant source references. Extracted data included (where available) baseline patient characteristics, ceftaroline fosamil dose and treatment duration, and reported treatment outcomes. For studies that included data for patients other than those with MRSA pneumonia, data for the subset of patients with MRSA pneumonia were extracted where available. Publication types excluded from the analysis included in vitro/non-human studies, review articles and meta-analyses based solely on previously published data, clinical pharmacology and PK/PD studies in humans that did not report clinical outcomes, and RCTs that did not include patients with MRSA pneumonia.

Search results

The results of the search and data extraction process are shown in figure 1. As of 10 January 2023, there were 541 results for the search “ceftaroline AND MRSA” and 195 results for the search “ceftaroline AND MRSA AND pneumonia”. In total, 14 publications were identified for data extraction and inclusion in the qualitative analysis, ranging in publication date from 2012 to 2021 [53–66] (table 4). Most (12 out of 14) publications were by US authors, with the remaining two publications by European authors. Of note, some publications reported the use of ceftaroline fosamil doses and/or duration of treatment that do not reflect current approved labelling. Across the 14 included publications, a total of 1908 patients were treated with ceftaroline fosamil and 264 patients were reported to have MRSA pneumonia or MRSA isolated from a lower respiratory tract source.

FIGURE 1.

Overview of literature search and data extraction.

TABLE 4.

Summary of real-world studies patients with methicillin-resistant Staphylococcus aureus (MRSA) pneumonia treated with ceftaroline fosamil

First author, year [ref.]	Design and setting	Baseline and treatment characteristics	Prior/concomitant antibiotics	Ceftaroline fosamil treatment duration	Main results
Giacobbe, 2021 [64]	Single-centre cross-sectional study, large teaching hospital, Italy, 2019	200 patients, median age 66 years, 72% male, of whom 165 (83%) had COVID-19	All 165 COVID-19 patients received empirical ceftaroline fosamil; in patients without COVID-19, ceftaroline fosamil was used as salvage therapy in 75% of cases; 7 patients (3%) received combination therapy	NR	MRSA identified in 4/15 patients (27%) with CAP; no discontinuation of ceftaroline due to treatment-emergent adverse events; outcome data NR for patients with MRSA pneumonia
Bassetti, 2020 [ 53 ]	Retrospective observational study, two hospitals in Spain and Italy, 2017–2018	89 patients with severe CAP treated with ceftaroline fosamil, including 9 patients with MRSA CAP; mean age 63 years, 66% male	53 cases (60%) treated in combination with other antibiotics	NR	30-day mortality and clinical success occurred in 18/89 (20%) and 57/89 (64%) patients, respectively; independent predictors of 30-day mortality were: increasing age, presence of solid neoplasm and concomitant therapy with oseltamivir; 5/9 patients (56%) with MRSA infection achieved clinical success
Karki, 2017 [ 54 ]	Retrospective case series, US community hospital, 2014–2016	31 patients with MRSA CAP (n=25) or HCAP (n=6) treated with ceftaroline fosamil for ≥7 days; 61% required mechanical ventilation and 65% were treated in the ICU	7 patients (23%) received concurrent anti-MRSA therapy (ceftaroline fosamil in these patients was added on when there was no clinical improvement on other MRSA therapy)	NR	Clinical success was achieved in 19/31 patients (62%), treatment failure occurred in 6/31 patients (19%); 5 patients (16%) had indeterminate outcomes; 6/31 patients (19%) died, of which 5 were related to the index infection; 6/11 patients (55%) with concomitant bacteraemia achieved clinical success; 5/7 patients (71%) treated with concurrent therapy achieved clinical success
Zasowski, 2017 [55]	Retrospective, multicentre US observational study, 2011–2015	126 patients received ceftaroline fosamil for 72 h for MRSA BSI, including 41 patients with LRTI source; overall median age 59 years; 45 patients (36%) were admitted to the ICU	107 patients (85%) received prior vancomycin and 48 patients (38%) received prior daptomycin; 37 patients (29%) received concomitant antibiotics with ceftaroline fosamil	Median (IQR): 11 (5–15) days	Clinical success was achieved in 86/126 patients (68%) overall and in 22/41 patients (54%) with LRTI source; APACHE II score and malignancy were independent predictors of treatment failure
Guervil, 2016 [ 65 ]	Retrospective chart review, US hospitals, 2011–2013	396 patients with CAP treated with ceftaroline fosamil as either first-line (n=67) or second-line (n=329) treatment; MRSA was isolated from 4/67 (6%) and 59/329 (18%) patients with CAP who received ceftaroline fosamil first or second line, respectively	All 329 patients in the second-line treatment group received prior antibiotics	Mean±sd: 5.8±3.0 days for first line and 6.2±4.6 days for second line	In patients with CAP, clinical success was achieved in 52/67 first-line patients (78%) and 262/329 second-line patients (80%); outcome data NR for patients with MRSA pneumonia
Faris, 2015 [56]	Case report, single US hospital	48-year-old female with MRSA VAP and bacteraemia; initially admitted to the ICU with thermal burn injury and ARDS	Patient initially treated with vancomycin and cefepime	14 days	After initiation of ceftaroline, rapid clinical improvement was observed with the patient becoming afebrile at 48 h; the patient was weaned from the ventilator on day 22 and decannulated 2 days later
Kaye, 2015 [57]	Retrospective chart review, US hospitals, 2013–2014	27 patients with HAP and 13 with VAP treated with ceftaroline fosamil; 14/27 patients (52%) with HAP and 13/13 patients (52%) with VAP admitted to the ICU; HAP patients: 59% male, mean age 63 years; VAP patients: 54% male, mean age 58 years; MRSA identified in 12/27 (44%) HAP and 7/13 (54%) VAP patients; 7/27 patients (26%) with HAP and 3/13 patients (23%) with VAP had associated bacteraemia	24 patients (89%) with HAP received prior antibiotics, mostly vancomycin and piperacillin–tazobactam (74% and 44%, respectively); 10 patients (77%) with VAP received prior antibiotics, most commonly vancomycin (62%), piperacillin–tazobactam (31%) and cefepime (31%)	Mean±sd: 6.9±3.6 days for patients with HAP and 7.7±3.2 days for patients with VAP	Clinical success rates were 75% overall, 82% in patients with HAP and 62% in patients with VAP; clinical success rates were 7/12 (58%) for patients with MRSA HAP and 4/7 (57%) for patients with MRSA VAP
Pasquale, 2015 [ 59 ]	Retrospective case series, US ICUs, 2011–2012	10 patients with MRSA pneumonia treated with ceftaroline fosamil (HCAP, n=6; HAP, n=3; VAP, n=1)	9/10 patients (90%) received prior anti-MRSA therapy	4–28 days	3/10 patients (30%) died; 6/7 of the remaining patients had clinical cure or improvement either at the end of therapy with ceftaroline or total antibiotic treatment; 1 patient had a relapse 1 week after ceftaroline fosamil treatment
Maggiore, 2015 [ 58 ]	Retrospective chart review, US hospitals, 2011–2013	398 patients with CAP treated with ceftaroline fosamil; 138 (35%) treated in the ICU and 256 (64%) in general medical wards (4 patients excluded from analysis); 33/81 ICU patients (41%) and 29/74 general medical ward patients (39%) with pathogens isolated had MRSA	87% of patients treated in the ICU and 80% of those treated in general medical wards received prior antibiotics	Mean: 7 days (ICU) and 6 days (general medical ward)	Clinical success was achieved in 68% of ICU patients and 85% of general medical ward patients; for patients with MRSA, clinical success was achieved in 56% of ICU patients and 76% of general medical ward patients; for patients with MSSA, clinical success was achieved in 69% of ICU patients and 83% of general medical ward patients
Vazquez, 2015 [ 60 ]	Retrospective chart review, US hospitals, 2011–2013	21 patients with S. aureus bacteraemia secondary to CAP treated with ceftaroline fosamil, including 16 cases with MRSA; mean age 60 years, 52% male, 33% treated in the ICU	86% had received prior antimicrobials; 71% received concurrent antimicrobials	Mean±sd: 7±3.8 days	Clinical success was achieved in 28/48 of all patients (58%) with S. aureus bacteraemia; among patients with S. aureus bacteraemia and CAP, 14/21 (67%) achieved clinical success, including 10/16 patients (63%) with MRSA and 4/5 patients (80%) with MSSA
Casapao, 2014 [ 66 ]	Retrospective case series, US hospitals, 2011–2013	527 patients received ceftaroline fosamil for >72 h, median age 60 years, 58% male; 99 patients had pneumonia (unspecified), of whom 92 were clinically evaluable	80% had switched from another antibiotic; 29% received concurrent antimicrobials	Median (IQR): 6 (4–9) days	Clinical success was achieved in 426/484 clinically evaluable patients (88%) overall; clinical failure occurred in 8/29 patients (28%) and mortality in 6/30 patients (20%) with S. aureus pneumonia; outcome data NR for patients with MRSA pneumonia
Griffiths, 2014 [ 61 ]	Case report, single US hospital	65-year-old female, admitted to the ICU with MRSA pneumonia, switched to ceftaroline fosamil after other treatments had failed	Empirical treatment with meropenem and vancomycin and 10 days of treatment with linezolid	5 days	On day 5 of ceftaroline treatment, the patient developed respiratory decompensation and peripheral eosinophilia of 40%; ceftaroline was discontinued, and the patient was started on vancomycin and methylprednisolone, with repeat BAL and peripheral blood counts showing resolved eosinophilia
Polenakovik, 2013 [ 62 ]	Case series, single US hospital, 2011–2012	31 patients with MRSA bacteraemia, median age 49 years, 71% male; 3 patients had pneumonia identified as the source of bacteraemia and a further 2 patients had pneumonia as a metastatic focus of bacteraemia	All patients had received prior anti-MRSA therapy	10–42 days (in 5 patients with MRSA pneumonia)	Clinical success was achieved in 23/31 patients (74%) overall and in 4/5 (80%) of those with pneumonia; 1 patient (20%) died; adverse events associated with prolonged therapy were rare, and included eosinophilic pneumonia, rash and diarrhoea
Lin, 2013 [63]	Case series, single US hospital, 2011	10 patients with deep-seated MRSA infections, including 2 patients with pneumonia (ages 64 and 88 years, both male)	All patients had received prior anti-MRSA therapy	8–30 days	1 patient with MRSA pneumonia died 3 days after completing 8 days of ceftaroline fosamil treatment; 1 patient with recurrent MRSA pneumonia with empyema due to bronchopleural fistula was clinically cured after two extended courses of ceftaroline fosamil treatment and discharged without recurrence of empyema in the following 12 months

COVID-19: coronavirus disease 2019; NR: not reported; CAP: community-acquired pneumonia; HCAP: healthcare-associated pneumonia; ICU: intensive care unit; BSI: bloodstream infection; LRTI: lower respiratory tract infection; IQR: interquartile range; APACHE: Acute Physiology and Chronic Health Evaluation; VAP: ventilator-associated pneumonia; ARDS: acute respiratory distress syndrome; HAP: hospital-acquired pneumonia; MSSA: methicillin-susceptible S. aureus; BAL: bronchoalveolar lavage.

Of the included publications, four included only patients with MRSA pneumonia and 10 included data on patients with MRSA pneumonia as part of a wider study population. The numbers of publications and patients with different categories of MRSA pneumonia were: CAP, six publications, 179 patients; HAP and/or VAP, three publications, 30 patients; and unspecified, five publications, 55 patients. In total, 11 publications, including 197 patients with MRSA pneumonia, reported clinical outcomes for ceftaroline fosamil treatment [53–63]. Three publications included patients with MRSA pneumonia (n=67 patients) but did not report sufficient information to extract clinical outcomes data for the included MRSA pneumonia patients [64–66].

Across three publications which reported outcomes for 92 patients with MRSA CAP treated with ceftaroline fosamil, 54–76% of patients achieved clinical success [53, 58, 60] and a clinical success rate of 63% was reported in a further study which reported combined outcomes for patients with MRSA CAP (n=25) or healthcare-associated pneumonia (HCAP) (n=6) [54]. Of note, the majority of patients (≥60%) in these studies had received prior antimicrobial therapy for MRSA and/or ceftaroline fosamil was administered in combination with other antibiotics (table 4).

Across two publications reporting outcomes for 50 patients with MRSA HCAP, HAP or VAP treated with ceftaroline fosamil, clinical success rates were 57–60%; >75% of patients in these studies had received prior antimicrobial therapy for MRSA [57, 59]. Across three studies that reported outcomes for 44 patients with unspecified MRSA pneumonia treated with ceftaroline fosamil, clinical success rates were 50–80%; 85–100% of patients in these studies had received prior antimicrobial therapy for MRSA [55, 62, 63]. In two individual case studies of patients with MRSA HAP or VAP, clinical success rates were zero out of one (0%) and one out of one (100%), respectively; in both of these cases, ceftaroline fosamil was given as second-line treatment following inadequate responses to other anti-MRSA treatments [56, 61]. The case which reported clinical failure (MRSA pneumonia in a 65-year-old female admitted to the ICU) was also associated with eosinophilic pneumonia which was attributed to ceftaroline fosamil and subsequently resolved with additional medical treatment [61].

Six publications included data on mortality following ceftaroline fosamil treatment, of which four included outcomes data for patients with MRSA pneumonia. The reported mortality rates were six out of 31 patients (19%) with CAP/HCAP [54], three out of 10 patients (30%) with HAP/VAP [59], one out of five patients (20%) with MRSA pneumonia and bacteraemia [62], and one out of two patients (50%) with pneumonia in a case series of 10 patients with deep-seated MRSA infections [63].

Discussion

MRSA pneumonia, whether categorised as CAP or HAP/VAP, is typically severe and potentially life threatening, and successful management requires rapid initiation of appropriate antimicrobial therapy. Ceftaroline fosamil is recognised as a potential alternative to standard first-line treatments for hospitalised patients with MRSA pneumonia [26, 27], although there is limited evidence from RCTs to support its use in this setting.

The current review of published literature describes real-world use and outcomes of ceftaroline fosamil in patients with pneumonia where MRSA was a confirmed pathogen. The literature search and data extraction were designed to cast a “wide net” to capture all relevant publications. While having the advantage of being inclusive, a potential disadvantage is that such an approach combines a heterogeneous dataset with different studies reporting various types of data and potentially using different end-points and definitions. Moreover, some of the studies reported the use of ceftaroline fosamil doses and/or durations of treatment outside of current approved labelling. Nonetheless, the studies included represent a variety of patient populations and clinical scenarios, including severe CAP and HAP/VAP, empiric and targeted/second-line use of ceftaroline fosamil, and a variety of complicated medical needs, and can thus be considered broadly representative of various real-world situations in which ceftaroline fosamil is used in practice.

Overall, reported clinical success rates for patients with MRSA CAP treated with ceftaroline fosamil were 54–76% and those for patients with MRSA HAP/VAP were 57–60%. Mortality rates, where reported, were in the range of 19–50%. While there were various methodological differences (such as in definitions of clinical success) across the included publications that limit interpretation, it is notable that across the studies a large proportion of patients received ceftaroline fosamil as second-line therapy following receipt of other antibiotics and a smaller proportion also received other concurrent anti-MRSA therapies. Unfortunately, with the exception of one publication [65], there was insufficient information within the reported data to discern separate outcomes for the groups of patients treated with first- or second-line therapy. Similarly, only one publication reported outcomes for monotherapy and concurrent anti-MRSA therapy [54]. However, in most cases included within the analysis, ceftaroline fosamil was used as second-line treatment because of treatment failure or because MRSA was detected after initial treatment with another regimen. It is possible that for some patients, mortality and other outcomes could have been better than those reported if ceftaroline fosamil was administered earlier.

While the current qualitive analysis of published studies was not designed as a formal statistical evaluation, our findings are consistent with those of a meta-analysis of RCTs and observational studies by Sotgiu et al. [67], in which the overall efficacy/effectiveness of ceftaroline fosamil in all types of pneumonia cases was 81% and in cases where MRSA was identified was 72%. The results are also broadly in line with findings from RCTs of ceftaroline fosamil in non-MRSA CAP (which evaluated empiric use of ceftaroline or ceftriaxone±azithromycin) [19, 20, 22] and with observational studies in other MRSA infections, where ceftaroline fosamil was used predominantly as second-line or salvage therapy [68, 69].

As with all antimicrobial therapies, the decision to prescribe ceftaroline fosamil should be made by qualified healthcare professionals with consideration for antimicrobial stewardship and guided where possible by culture and susceptibility results as well as local/institutional surveillance data. Particularly with regard to MRSA pneumonia, careful consideration of MIC results is required in the context of the different EUCAST MIC breakpoints for ceftaroline against S. aureus for pneumonia and non-pneumonia isolates and CLSI dose-dependent susceptibility [50, 51]. It is anticipated that the development of rapid bacterial diagnostics will lead to improvements in the management of pneumonia (including cases caused by MRSA) as well as support antimicrobial stewardship (e.g. by reducing the unnecessary use of empiric anti-MRSA agents and supporting rapid de-escalation) [38, 70].

In summary, although there are scarce data available from RCTs evaluating ceftaroline fosamil in adults with MRSA pneumonia, there is good evidence of its comparative effectiveness and safety profile in CAP caused by other pathogens, including MSSA. There is also available evidence from in vitro, pre-clinical and clinical pharmacology studies and clinical experience reported in real-world observational studies and case reports demonstrating the utility of ceftaroline fosamil in patients with pneumonia where MRSA is a confirmed pathogen. While the available evidence does not suggest ceftaroline fosamil should be used in preference to the standard recommended treatments for MRSA pneumonia (vancomycin and linezolid), the data indicate that it may be a valuable additional treatment option in this setting. Specific scenarios in which ceftaroline fosamil might be used in preference to other anti-MRSA agents in patients with pneumonia include cases involving bacteraemia, as well as those with complicating factors such as empyema, which can require longer treatment durations than are typical for other types of pneumonia.

Points for clinical practice

Rapid initiation of appropriate empirical therapy is needed to optimise outcomes for patients with pneumonia where MRSA is a suspected or confirmed pathogen. While vancomycin and linezolid are usually considered as first-line therapies, ceftaroline fosamil has an established clinical profile in the treatment of CAP in hospitalised patients, and although data from RCTs in patients with MRSA pneumonia are lacking, in vitro and in vivo PK/PD data, lung tissue penetration and real-world outcomes studies indicate that ceftaroline fosamil is a possible alternative to linezolid and vancomycin for MRSA pneumonia.