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. 1965 Nov;13(6):956–966. doi: 10.1128/am.13.6.956-966.1965

Site of Action of Certain Antibacterial Heterocyclic Quaternary Ammonium Compounds

W A Cox 1
PMCID: PMC1058378  PMID: 4956041

Abstract

The site of action of related mono- and bis-quinaldinium compounds was investigated in Staphylococcus aureus and Bacillus megaterium. The effects of these compounds on cell morphology and on protoplast formation and fragility were studied, and the distribution of C14-labeled quinaldinium compound in cell fractions was measured. The latter studies showed that a major part of the quaternary compound penetrates the cell, leaving a very small quantity associated with the cell wall. Similar antibacterial effects were seen with both the mono- and bis-quinaldinium compounds studied, and these effects were comparable with antibacterial properties of known cationic surface-active antibacterial agents.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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