Abstract
Chloramphenicol or its isomers, if supplied within 4 hr after the addition of Mn+2, prevented sporulation of Bacillus megaterium at concentrations that partially inhibited protein synthesis but which were neither bacteriostatic nor bactericidal. Likewise, sub-bactericidal quantities of the compounds, if supplied within 2 hr after the addition of Mn+2, suppressed formation of bacitracin by B. licheniformis. In contrast to previous reports that chloramphenicol is less active than its isomers against sporulation and peptide formation, the results of the present study indicated that the order and extent of these activities of the compounds is similar to that of their ability to prevent growth and to suppress protein synthesis; i.e., d(-)-threo > l(+)-erythro > d(-)-erythro.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- AUBERT J. P., MILLET J., PINEAU E., MILHAUD G. [N-Succinyl-L-glutamic acid in Bacillus megaterium during sporulation]. Biochim Biophys Acta. 1961 Aug 19;51:529–537. doi: 10.1016/0006-3002(61)90610-2. [DOI] [PubMed] [Google Scholar]
- BERNLOHR R. W., NOVELLI G. D. BACITRACIN BIOSYNTHESIS AND SPORE FORMATION: THE PHYSIOLOGICAL ROLE OF AN ANTIBIOTIC. Arch Biochem Biophys. 1963 Oct;103:94–104. doi: 10.1016/0003-9861(63)90014-6. [DOI] [PubMed] [Google Scholar]
- BROCK T. D. Inhibition of endotrophic sporulation by antibiotics. Nature. 1962 Jul 21;195:309–309. doi: 10.1038/195309a0. [DOI] [PubMed] [Google Scholar]
- Brock T. D. CHLORAMPHENICOL. Bacteriol Rev. 1961 Mar;25(1):32–48. doi: 10.1128/br.25.1.32-48.1961. [DOI] [PMC free article] [PubMed] [Google Scholar]
- CORNELL N., SNOKE J. E. BIOSYNTHESIS OF BACITRACIN AND PROTEIN. Biochim Biophys Acta. 1964 Nov 15;91:533–536. doi: 10.1016/0926-6550(64)90086-6. [DOI] [PubMed] [Google Scholar]
- Kominek L. A., Halvorson H. O. Metabolism of poly-beta-hydroxybutyrate and acetoin in Bacillus cereus. J Bacteriol. 1965 Nov;90(5):1251–1259. doi: 10.1128/jb.90.5.1251-1259.1965. [DOI] [PMC free article] [PubMed] [Google Scholar]
- LEONARD C. G., HOUSEWRIGHT R. D., THORNE C. B. Effects of some metallic ions on glutamyl polypeptide synthesis by Bacillus subtilis. J Bacteriol. 1958 Nov;76(5):499–503. doi: 10.1128/jb.76.5.499-503.1958. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Mach B., Reich E., Tatum E. L. SEPARATION OF THE BIOSYNTHESIS OF THE ANTIBIOTIC POLYPEPTIDE TYROCIDINE FROM PROTEIN BIOSYNTHESIS. Proc Natl Acad Sci U S A. 1963 Jul;50(1):175–181. doi: 10.1073/pnas.50.1.175. [DOI] [PMC free article] [PubMed] [Google Scholar]
- RENDI R., OCHOA S. Effect of chloramphenicol on protein synthesis in cell-free preparations of Escherichia coli. J Biol Chem. 1962 Dec;237:3711–3713. [PubMed] [Google Scholar]
- Ryter A., Szulmajster J. Action du chloramphénicol sur la sporogenèse de B. subtilis. Ann Inst Pasteur (Paris) 1965 May;108(5):640–651. [PubMed] [Google Scholar]
- SLEPECKY R., FOSTER J. W. Alterations in metal content of spores of Bacillus megaterium and the effect on some spore properties. J Bacteriol. 1959 Jul;78(1):117–123. doi: 10.1128/jb.78.1.117-123.1959. [DOI] [PMC free article] [PubMed] [Google Scholar]
- VINTER V. Spores of microorganisms. Chloramphenicol-sensitive and penicillin-resistant incorporation of 14C-diaminopimelic acid into sporulating cells of Bacillus cereus. Experientia. 1963 Jun 15;19:307–308. doi: 10.1007/BF02150422. [DOI] [PubMed] [Google Scholar]
- WEINBERG E. D. MANGANESE REQUIREMENT FOR SPORULATION AND OTHER SECONDARY BIOSYNTHETIC PROCESSES OF BACILLUS. Appl Microbiol. 1964 Sep;12:436–441. doi: 10.1128/am.12.5.436-441.1964. [DOI] [PMC free article] [PubMed] [Google Scholar]
- WEINBERG E. D. The effect of Mn++ and antimicrobial drugs on sporulation of Bacillus subtilis in nutrient broth. J Bacteriol. 1955 Sep;70(3):289–296. doi: 10.1128/jb.70.3.289-296.1955. [DOI] [PMC free article] [PubMed] [Google Scholar]