Skip to main content
Applied Microbiology logoLink to Applied Microbiology
. 1966 Nov;14(6):989–992. doi: 10.1128/am.14.6.989-992.1966

β-Propiolactone Vapor Decontamination

Robert K Hoffman 1, Lee M Buchanan 1, David R Spiner 1
PMCID: PMC1058454  PMID: 16349707

Abstract

Although β-propiolactone (BPL) is an effective vapor-phase decontaminant for enclosed areas, some problems have been encountered in its use. Adequate air circulation during BPL dissemination could eliminate most of these problems. It is recommended that, when decontaminating the ordinary building or laboratory, the amount of BPL sprayed be changed from the previously suggested 1 gal/16,000 cubic ft of space to 1 gal/25,000 cubic ft. The use of aqueous BPL solutions and thermal-type generators is not recommended.

Full text

PDF
989

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Barbeito M. S. Emergency disinfection of operating room and patient ward with beta-propiolactone. Hospitals. 1966 Mar 16;40(6):100–106. doi: 10.21236/ad0640342. [DOI] [PubMed] [Google Scholar]
  2. DAWSON F. W., HEARN H. J., HOFFMAN R. K. Virucidal activity of beta-propiolactone vapor. I. Effect of beta-propiolactone vapor on Venezuelan equine encephalomyelitis virus. Appl Microbiol. 1959 Jul;7(4):199–201. doi: 10.1128/am.7.4.199-201.1959. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. GLENDENNING O. M., ROE F. J. The carcinogenicity of beta-propiolactone for mouseskin. Br J Cancer. 1956 Jun;10(2):357–362. doi: 10.1038/bjc.1956.41. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. HOFFMAN R. K., WARSHOWSKY B. Betapropiolactone vapor as a disinfectant. Appl Microbiol. 1958 Sep;6(5):358–362. doi: 10.1128/am.6.5.358-362.1958. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Karlson A. G., Weed L. A. Beta-propiolactone as used in sterilization of homografts not carcinogenic for mice. Mayo Clin Proc. 1966 Jan;41(1):24–28. [PubMed] [Google Scholar]
  6. PALMES E. D., ORRIS L., NELSON N. Skin irritation and skin tumor production by beta propiolactone (BPL). Am Ind Hyg Assoc J. 1962 Jul-Aug;23:257–264. doi: 10.1080/00028896209342866. [DOI] [PubMed] [Google Scholar]
  7. SPINER D. R., HOFFMAN R. K. Method for disinfecting large enclosures with beta-propiolactone vapor. Appl Microbiol. 1960 May;8:152–155. doi: 10.1128/am.8.3.152-155.1960. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. WALPOLE A. L., ROBERTS D. C., ROSE F. L., HENDRY J. A., HOMER R. F. Cytotoxic agents. IV. The carcinogenic actions of some monofunctional ethyleneimine derivatives. Br J Pharmacol Chemother. 1954 Sep;9(3):306–323. doi: 10.1111/j.1476-5381.1954.tb01686.x. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Applied Microbiology are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES