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. 2023 Oct 4;26(11):108095. doi: 10.1016/j.isci.2023.108095

Figure 6.

Figure 6

Schematic representation of the various proteoglycans and proteoglycan fragments evoking autophagy

(A) Decorin and endorepellin share VEGFR2 to target endothelial cells. However, decorin uses the MET receptor to evoke mitophagy in cancer cells. Instead, endorepellin requires the co-receptor α2β1 integrin to evoke autophagy in endothelial cells sharing similar pathways. Endostatin acts via the α5β1 integrin in endothelial cells.

(B) Effects of biglycan on macrophage autophagy are mediated by a complex of receptors including TOLL2/4, CD14, and CD44. For additional details, please refer to the text. The graphic was created with BioRender.com.