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. 2023 Oct 19;11:e16300. doi: 10.7717/peerj.16300

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© 2023 Somsura et al.

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited.

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Diagram explains the mechanism of senescent cell progression from initiation to full senescence (A), and timeline of the present experiment (B), please see text for detail. CDKIs, cyclin-dependent kinase inhibitors; ROS, reactive oxygen species; SA-β-gal, senescence-associated β-galactosidase; SASPs, senescence-associated secretory phenotypes; SHR, spontaneously hypertensive rat; WT, normotensive wild-type rats; SBP, systolic blood pressure; DBP, diastolic blood pressure; MAP, mean arterial blood pressure.