Abstract
STUDY OBJECTIVE--The aim was to estimate fracture rates and fracture prevalence from fracture histories in normal postmenopausal women. DESIGN--Apparently healthy postmenopausal women were recruited by advertising in the media. Fracture histories were obtained by personal interview in 1983 and again by interview or questionnaire in 1988. Fracture rates were calculated prospectively and retrospectively. PARTICIPANTS--492 women (mean age 58.6 years) were selected from over 1000 applicants on the basis that they were suffering from no disease nor taking any therapy which might affect their bones. MEASUREMENTS AND MAIN RESULTS--Retrospective premenopausal and postmenopausal fracture rates were calculated in 1983, prospective rates calculated from 1983 to 1988, and retrospective rates checked again on the second occasion. The retrospective and prospective fracture rates were very similar. The five year fracture rates were low and steady until the menopause, when they rose by a factor of 10 and reached a new plateau after about 15 years. The results were comparable to those obtained from hospital statistics. CONCLUSIONS--The menopausal rise in fracture rates not only involves wrist fractures but most peripheral fractures, and probably reflects postmenopausal loss of trabecular bone. Meaningful fracture rates can be calculated from individual fracture histories in a well defined population. This technique may be particularly useful in developing countries where public health data may be incomplete.
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Selected References
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- Boyce W. J., Vessey M. P. Rising incidence of fracture of the proximal femur. Lancet. 1985 Jan 19;1(8421):150–151. doi: 10.1016/s0140-6736(85)91915-4. [DOI] [PubMed] [Google Scholar]
- Cleghorn D. B., Polley K. J., Bellon M. J., Chatterton J., Baghurst P. A., Nordin B. E. Fracture rates as a function of forearm mineral density in normal postmenopausal women: retrospective and prospective data. Calcif Tissue Int. 1991 Sep;49(3):161–163. doi: 10.1007/BF02556110. [DOI] [PubMed] [Google Scholar]
- Gallagher J. C., Goldgar D., Moy A. Total bone calcium in normal women: effect of age and menopause status. J Bone Miner Res. 1987 Dec;2(6):491–496. doi: 10.1002/jbmr.5650020605. [DOI] [PubMed] [Google Scholar]
- KNOWELDEN J., BUHR A. J., DUNBAR O. INCIDENCE OF FRACTURES IN PERSONS OVER 35 YEARS OF AGE. A REPORT TO THE M.R.C. WORKING PARTY ON FRACTURES IN THE ELDERLY. Br J Prev Soc Med. 1964 Jul;18:130–141. doi: 10.1136/jech.18.3.130. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Nilas L., Christiansen C. Bone mass and its relationship to age and the menopause. J Clin Endocrinol Metab. 1987 Oct;65(4):697–702. doi: 10.1210/jcem-65-4-697. [DOI] [PubMed] [Google Scholar]
- Nordin B. E., Chatterton B. E., Walker C. J., Wishart J. The relation of forearm mineral density to peripheral fractures in postmenopausal women. Med J Aust. 1987 Mar 16;146(6):300–304. doi: 10.5694/j.1326-5377.1987.tb120266.x. [DOI] [PubMed] [Google Scholar]
- Nordin B. E., Need A. G., Chatterton B. E., Horowitz M., Morris H. A. The relative contributions of age and years since menopause to postmenopausal bone loss. J Clin Endocrinol Metab. 1990 Jan;70(1):83–88. doi: 10.1210/jcem-70-1-83. [DOI] [PubMed] [Google Scholar]
- Nordin B. E., Polley K. J. Metabolic consequences of the menopause. A cross-sectional, longitudinal, and intervention study on 557 normal postmenopausal women. Calcif Tissue Int. 1987;41 (Suppl 1):S1–59. [PubMed] [Google Scholar]
- Riggs B. L., Melton L. J., 3rd Evidence for two distinct syndromes of involutional osteoporosis. Am J Med. 1983 Dec;75(6):899–901. doi: 10.1016/0002-9343(83)90860-4. [DOI] [PubMed] [Google Scholar]