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Journal of Epidemiology and Community Health logoLink to Journal of Epidemiology and Community Health
. 1993 Feb;47(1):46–49. doi: 10.1136/jech.47.1.46

Sunlight exposure, antioxidant status, and cataract in Hong Kong fishermen.

L Wong 1, S C Ho 1, D Coggon 1, A M Cruddas 1, C H Hwang 1, C P Ho 1, A M Robertshaw 1, D M MacDonald 1
PMCID: PMC1059710  PMID: 8436894

Abstract

STUDY OBJECTIVES--The aim was to test whether cataract is associated with higher lifetime exposure to sunlight, and whether antioxidants protect against cataract. DESIGN--This was a cross sectional survey of eye disease, with assessment of antioxidant status in a subgroup. SETTING--Hong Kong fishing communities in 1989. PARTICIPANTS--685 men and women aged 55 to 74 years old were included in the study, of whom 367 (54%) attended hospital for detailed examination. MEASUREMENTS AND MAIN RESULTS--At a mobile clinic visual acuity and lens opacities were assessed, and using a questionnaire, occupational history and lifetime exposure to sunlight. At hospital ophthalmic measurements were repeated and blood was taken for measurement of plasma vitamin C, vitamin E, and total carotenoids, and red cell activities of glucose-6-phosphate dehydrogenase, glutathione peroxidase, superoxide dismutase, and catalase. Higher grades of cataract (particularly nuclear cataract) tended to be more common in subjects with the most sun exposure, although not to the point of statistical significance. In contrast to earlier studies, no association was found with antioxidant status. CONCLUSIONS--The findings give some support to the hypothesis that sunlight causes cataract. The absence of a relation to antioxidant status may be because blood levels of antioxidants at one point in time do not adequately reflect a subject's past metabolic state, and particularly the past activity of antioxidants in the lens.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bochow T. W., West S. K., Azar A., Munoz B., Sommer A., Taylor H. R. Ultraviolet light exposure and risk of posterior subcapsular cataracts. Arch Ophthalmol. 1989 Mar;107(3):369–372. doi: 10.1001/archopht.1989.01070010379027. [DOI] [PubMed] [Google Scholar]
  2. Brilliant L. B., Grasset N. C., Pokhrel R. P., Kolstad A., Lepkowski J. M., Brilliant G. E., Hawks W. N., Pararajasegaram R. Associations among cataract prevalence, sunlight hours, and altitude in the Himalayas. Am J Epidemiol. 1983 Aug;118(2):250–264. doi: 10.1093/oxfordjournals.aje.a113632. [DOI] [PubMed] [Google Scholar]
  3. Chan C. K. Measurement of erythrocyte glucose-6-phosphate dehydrogenase activity using a centrifugal analyzer. Med Lab Sci. 1984 Apr;41(2):112–120. [PubMed] [Google Scholar]
  4. Collman G. W., Shore D. L., Shy C. M., Checkoway H., Luria A. S. Sunlight and other risk factors for cataracts: an epidemiologic study. Am J Public Health. 1988 Nov;78(11):1459–1462. doi: 10.2105/ajph.78.11.1459. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Deutsch J. Maleimide as an inhibitor in measurement of erythrocyte glucose-6-phosphate dehydrogenase activity. Clin Chem. 1978 Jun;24(6):885–889. [PubMed] [Google Scholar]
  6. Dolezal J. M., Perkins E. S., Wallace R. B. Sunlight, skin sensitivity, and senile cataract. Am J Epidemiol. 1989 Mar;129(3):559–568. doi: 10.1093/oxfordjournals.aje.a115168. [DOI] [PubMed] [Google Scholar]
  7. Eckerskorn U., Hockwin O., Müller-Breitenkamp R., Chen T. T., Knowles W., Dobbs R. E. Evaluation of cataract-related risk factors using detailed classification systems and multivariate statistical methods. Dev Ophthalmol. 1987;15:82–91. doi: 10.1159/000414697. [DOI] [PubMed] [Google Scholar]
  8. Hiller R., Giacometti L., Yuen K. Sunlight and cataract: an epidemiologic investigation. Am J Epidemiol. 1977 May;105(5):450–459. doi: 10.1093/oxfordjournals.aje.a112404. [DOI] [PubMed] [Google Scholar]
  9. Hiller R., Sperduto R. D., Ederer F. Epidemiologic associations with cataract in the 1971-1972 National Health and Nutrition Examination Survey. Am J Epidemiol. 1983 Aug;118(2):239–249. doi: 10.1093/oxfordjournals.aje.a113631. [DOI] [PubMed] [Google Scholar]
  10. Hollows F., Moran D. Cataract--the ultraviolet risk factor. Lancet. 1981 Dec 5;2(8258):1249–1250. doi: 10.1016/s0140-6736(81)91490-2. [DOI] [PubMed] [Google Scholar]
  11. Jacques P. F., Chylack L. T., Jr, McGandy R. B., Hartz S. C. Antioxidant status in persons with and without senile cataract. Arch Ophthalmol. 1988 Mar;106(3):337–340. doi: 10.1001/archopht.1988.01060130363022. [DOI] [PubMed] [Google Scholar]
  12. Jose J. G. Posterior cataract induction by UV-B radiation in albino mice. Exp Eye Res. 1986 Jan;42(1):11–20. doi: 10.1016/0014-4835(86)90013-8. [DOI] [PubMed] [Google Scholar]
  13. L'Abbé M. R., Fischer P. W. An automated method for the determination of Cu,Zn-superoxide dismutase in plasma and erythrocytes using an ABA-200 discrete analyzer. Clin Biochem. 1986 Jun;19(3):175–178. doi: 10.1016/s0009-9120(86)80019-4. [DOI] [PubMed] [Google Scholar]
  14. Leske M. C., Chylack L. T., Jr, Sperduto R., Pennett M., McCarthy D. Progress toward developing a cataract classification system. Dev Ophthalmol. 1987;15:9–15. doi: 10.1159/000414685. [DOI] [PubMed] [Google Scholar]
  15. Liu T. Z., Chin N., Kiser M. D., Bigler W. N. Specific spectrophotometry of ascorbic acid in serum or plasma by use of ascorbate oxidase. Clin Chem. 1982 Nov;28(11):2225–2228. [PubMed] [Google Scholar]
  16. Maraini G., Tomba M. C., Bonacini M. Preliminary evaluation of a simple photographic cataract classification for epidemiological surveys. Dev Ophthalmol. 1987;15:1–4. doi: 10.1159/000414683. [DOI] [PubMed] [Google Scholar]
  17. Mitchell B. D., Lepkowski J. M. The epidemiology of cataract in Nepal. Hum Biol. 1986 Dec;58(6):975–990. [PubMed] [Google Scholar]
  18. Mohan M., Sperduto R. D., Angra S. K., Milton R. C., Mathur R. L., Underwood B. A., Jaffery N., Pandya C. B., Chhabra V. K., Vajpayee R. B. India-US case-control study of age-related cataracts. India-US Case-Control Study Group. Arch Ophthalmol. 1989 May;107(5):670–676. doi: 10.1001/archopht.1989.01070010688028. [DOI] [PubMed] [Google Scholar]
  19. Pirie A. Photo-oxidation of proteins and comparison of photo-oxidized proteins with those of the cataractous human lens. Isr J Med Sci. 1972 Aug-Sep;8(8):1567–1573. [PubMed] [Google Scholar]
  20. Pleban P. A., Munyani A., Beachum J. Determination of selenium concentration and glutathione peroxidase activity in plasma and erythrocytes. Clin Chem. 1982 Feb;28(2):311–316. [PubMed] [Google Scholar]
  21. Schwab L. Cataract blindness in developing nations. Int Ophthalmol Clin. 1990 Winter;30(1):16–18. [PubMed] [Google Scholar]
  22. Sliney D. H. Physical factors in cataractogenesis: ambient ultraviolet radiation and temperature. Invest Ophthalmol Vis Sci. 1986 May;27(5):781–790. [PubMed] [Google Scholar]
  23. Taylor A. Associations between nutrition and cataract. Nutr Rev. 1989 Aug;47(8):225–234. doi: 10.1111/j.1753-4887.1989.tb02848.x. [DOI] [PubMed] [Google Scholar]
  24. Taylor H. R. The environment and the lens. Br J Ophthalmol. 1980 May;64(5):303–310. doi: 10.1136/bjo.64.5.303. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Taylor H. R. Ultraviolet radiation and the eye: an epidemiologic study. Trans Am Ophthalmol Soc. 1989;87:802–853. [PMC free article] [PubMed] [Google Scholar]
  26. Taylor H. R., West S. K., Rosenthal F. S., Muñoz B., Newland H. S., Abbey H., Emmett E. A. Effect of ultraviolet radiation on cataract formation. N Engl J Med. 1988 Dec 1;319(22):1429–1433. doi: 10.1056/NEJM198812013192201. [DOI] [PubMed] [Google Scholar]
  27. Zigman S., Schultz J., Yulo T. Possible roles of near UV light in the cataractous process. Exp Eye Res. 1973 Feb;15(2):201–208. doi: 10.1016/0014-4835(73)90120-6. [DOI] [PubMed] [Google Scholar]

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