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Journal of Epidemiology and Community Health logoLink to Journal of Epidemiology and Community Health
. 1994 Dec;48(6):576–579. doi: 10.1136/jech.48.6.576

Primary infertility: characteristics of women in North America according to pathological findings.

V Beral 1, R Rolfs 1, M R Joesoef 1, S Aral 1, D W Cramer 1
PMCID: PMC1060035  PMID: 7830012

Abstract

STUDY OBJECTIVE--To determine, in women with primary infertility, whether specific characteristics or behavioural factors are associated with the various pathological conditions identified as contributing to the infertility. DESIGN--Case-control study. SETTING--Seven institutions in the USA or Canada. PARTICIPANTS--Study subjects were 1750 women who presented with primary infertility, among whom the main pathological cause of infertility was male factor (417), tubal obstruction (231), endometriosis (194), luteal phase defects (153), other ovulatory problems (193), cervical abnormalities (92), and polycystic ovarian disease (84) and 1765 control women who delivered their first child at the same institution. MAIN RESULTS--Except for tubal obstruction and polycystic ovarian disease, the characteristics and behaviours of the women with infertility did not differ appreciably according to the pathological conditions recorded. Women with tubal obstruction had had more sexual partners, an earlier age at first intercourse, were more likely to have used an intrauterine device but less likely to have used a condom, and were more likely to have smoked cigarettes and to have used various recreational drugs than the other women. Women with polycystic ovarian disease were more obese, had had fewer sexual partners, and were less likely to have used cigarettes, contraceptives, and recreational drugs than the other women. CONCLUSIONS--Sexually transmitted infections seem to increase the risk of tubal obstruction but not other causes of infertility. Obesity is associated with polycystic ovarian disease. These data offer few clues to the aetiology of infertility attributed to endometriosis, cervical abnormalities, luteal phase defects, other ovulatory defects, or to male factors.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aral S. O., Cates W., Jr The increasing concern with infertility. Why now? JAMA. 1983 Nov 4;250(17):2327–2331. [PubMed] [Google Scholar]
  2. Cramer D. W., Goldman M. B., Schiff I., Belisle S., Albrecht B., Stadel B., Gibson M., Wilson E., Stillman R., Thompson I. The relationship of tubal infertility to barrier method and oral contraceptive use. JAMA. 1987 May 8;257(18):2446–2450. [PubMed] [Google Scholar]
  3. Cramer D. W., Schiff I., Schoenbaum S. C., Gibson M., Belisle S., Albrecht B., Stillman R. J., Berger M. J., Wilson E., Stadel B. V. Tubal infertility and the intrauterine device. N Engl J Med. 1985 Apr 11;312(15):941–947. doi: 10.1056/NEJM198504113121502. [DOI] [PubMed] [Google Scholar]
  4. Cramer D. W., Wilson E., Stillman R. J., Berger M. J., Belisle S., Schiff I., Albrecht B., Gibson M., Stadel B. V., Schoenbaum S. C. The relation of endometriosis to menstrual characteristics, smoking, and exercise. JAMA. 1986 Apr 11;255(14):1904–1908. [PubMed] [Google Scholar]
  5. Daling J. R., Weiss N. S., Metch B. J., Chow W. H., Soderstrom R. M., Moore D. E., Spadoni L. R., Stadel B. V. Primary tubal infertility in relation to the use of an intrauterine device. N Engl J Med. 1985 Apr 11;312(15):937–941. doi: 10.1056/NEJM198504113121501. [DOI] [PubMed] [Google Scholar]
  6. Joesoef M. R., Beral V., Rolfs R. T., Aral S. O., Cramer D. W. Are caffeinated beverages risk factors for delayed conception? Lancet. 1990 Jan 20;335(8682):136–137. doi: 10.1016/0140-6736(90)90005-p. [DOI] [PubMed] [Google Scholar]
  7. Phipps W. R., Cramer D. W., Schiff I., Belisle S., Stillman R., Albrecht B., Gibson M., Berger M. J., Wilson E. The association between smoking and female infertility as influenced by cause of the infertility. Fertil Steril. 1987 Sep;48(3):377–382. doi: 10.1016/s0015-0282(16)59402-3. [DOI] [PubMed] [Google Scholar]

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