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. 1996 Jun;50(3):258–263. doi: 10.1136/jech.50.3.258

Physical activity, physical fitness, blood pressure, and fibrinogen in the Northern Ireland health and activity survey.

D MacAuley 1, E E McCrum 1, G Stott 1, A E Evans 1, B McRoberts 1, C A Boreham 1, K Sweeney 1, T R Trinick 1
PMCID: PMC1060280  PMID: 8935455

Abstract

STUDY OBJECTIVE: To investigate the relationship between physical activity, physical fitness, blood pressure, and fibrinogen. DESIGN: This was a cross sectional population study using a two stage probability sample. SETTING: Northern Ireland. PARTICIPANTS: A sample of 1600 subjects aged 16-74 years from the population of Northern Ireland. MAIN OUTCOME MEASURES: Physical activity profile from computer assisted interview using the Allied Dunbar national fitness survey scales. Physical fitness using estimation of VO2 max by extrapolation from submaximal oxygen uptake while walking on a motor driven treadmill. Systolic and diastolic blood pressure measured with a Hawksley random zero sphygmomanometer. Measurement of fibrinogen using the Clauss method. MAIN RESULTS: There were significant relationships between both current and past activity and blood pressure. These were of a magnitude that would have been clinically significant, but for the fact that, with the exception of the relationship between habitual activity and diastolic pressure (p = 0.03) and past activity and systolic pressure (p = 0.03) in men, they were not sustained after adjustment for the effect of age using analysis of variance. After adjustment for other potentially confounding factors using multiple regression, there was an inverse relationship between systolic blood pressure and past activity in men, so that those with a life-time of participation compared with a life-time of inactivity had a lower systolic blood pressure of 6 mmHg (p < 0.05). There was a highly significant (p < 0.001) inverse association between both systolic and diastolic blood pressure and physical fitness (VO2 max) which was not sustained after adjustment for possible confounding factors. There were relationships between fibrinogen and highest recorded activity (p < 0.001), habitual activity (p < 0.01), and past activity (p < 0.01) in men but no significant relationship in women. The relationship between fibrinogen and activity was no longer sustained after adjustment for possible confounding factors. There was a highly significant (p < 0.001) inverse relationship with physical fitness using VO2 max. This relationship was sustained after adjustment for possible confounding factors in both men (p < 0.05) and women (p < 0.001). CONCLUSIONS: There was a relationship between physical activity, physical fitness, and blood pressure but the relationship was greatly influenced by age. A reduction of 6 mmHg in systolic blood pressure associated with past activity is of clinical significance and supports the hypothesis that physical activity is of benefit in reducing cardiovascular risk. There was a lower level of fibrinogen in those who were most active but this relationship was not significant after adjustment for possible confounding factors. There was also a lower level of fibrinogen those who were most fit (VO2 max) and this relationship persisted even after adjustment for possible confounding factors.

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Selected References

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  1. Blair S. N., Goodyear N. N., Gibbons L. W., Cooper K. H. Physical fitness and incidence of hypertension in healthy normotensive men and women. JAMA. 1984 Jul 27;252(4):487–490. [PubMed] [Google Scholar]
  2. CLAUSS A. Gerinnungsphysiologische Schnellmethode zur Bestimmung des Fibrinogens. Acta Haematol. 1957 Apr;17(4):237–246. doi: 10.1159/000205234. [DOI] [PubMed] [Google Scholar]
  3. Connelly J. B., Cooper J. A., Meade T. W. Strenuous exercise, plasma fibrinogen, and factor VII activity. Br Heart J. 1992 May;67(5):351–354. doi: 10.1136/hrt.67.5.351. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Elwood P. C., Yarnell J. W., Pickering J., Fehily A. M., O'Brien J. R. Exercise, fibrinogen, and other risk factors for ischaemic heart disease. Caerphilly Prospective Heart Disease Study. Br Heart J. 1993 Feb;69(2):183–187. doi: 10.1136/hrt.69.2.183. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Ernst E. Regular exercise reduces fibrinogen levels: a review of longitudinal studies. Br J Sports Med. 1993 Sep;27(3):175–176. doi: 10.1136/bjsm.27.3.175. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Folsom A. R., Wu K. K., Davis C. E., Conlan M. G., Sorlie P. D., Szklo M. Population correlates of plasma fibrinogen and factor VII, putative cardiovascular risk factors. Atherosclerosis. 1991 Dec;91(3):191–205. doi: 10.1016/0021-9150(91)90167-2. [DOI] [PubMed] [Google Scholar]
  7. Gordon N. F., Scott C. B., Wilkinson W. J., Duncan J. J., Blair S. N. Exercise and mild essential hypertension. Recommendations for adults. Sports Med. 1990 Dec;10(6):390–404. doi: 10.2165/00007256-199010060-00005. [DOI] [PubMed] [Google Scholar]
  8. Kannel W. B., Wolf P. A., Castelli W. P., D'Agostino R. B. Fibrinogen and risk of cardiovascular disease. The Framingham Study. JAMA. 1987 Sep 4;258(9):1183–1186. [PubMed] [Google Scholar]
  9. Lakka T. A., Salonen J. T. Moderate to high intensity conditioning leisure time physical activity and high cardiorespiratory fitness are associated with reduced plasma fibrinogen in eastern Finnish men. J Clin Epidemiol. 1993 Oct;46(10):1119–1127. doi: 10.1016/0895-4356(93)90111-d. [DOI] [PubMed] [Google Scholar]
  10. Lee A. J., Smith W. C., Lowe G. D., Tunstall-Pedoe H. Plasma fibrinogen and coronary risk factors: the Scottish Heart Health Study. J Clin Epidemiol. 1990;43(9):913–919. doi: 10.1016/0895-4356(90)90075-z. [DOI] [PubMed] [Google Scholar]
  11. Leon A. S., Connett J., Jacobs D. R., Jr, Rauramaa R. Leisure-time physical activity levels and risk of coronary heart disease and death. The Multiple Risk Factor Intervention Trial. JAMA. 1987 Nov 6;258(17):2388–2395. [PubMed] [Google Scholar]
  12. Meade T. W., Mellows S., Brozovic M., Miller G. J., Chakrabarti R. R., North W. R., Haines A. P., Stirling Y., Imeson J. D., Thompson S. G. Haemostatic function and ischaemic heart disease: principal results of the Northwick Park Heart Study. Lancet. 1986 Sep 6;2(8506):533–537. doi: 10.1016/s0140-6736(86)90111-x. [DOI] [PubMed] [Google Scholar]
  13. Montoye H. J., Metzner H. L., Keller J. B., Johnson B. C., Epstein F. H. Habitual physical activity and blood pressure. Med Sci Sports. 1972 Winter;4(4):175–181. [PubMed] [Google Scholar]
  14. Morris J. N., Clayton D. G., Everitt M. G., Semmence A. M., Burgess E. H. Exercise in leisure time: coronary attack and death rates. Br Heart J. 1990 Jun;63(6):325–334. doi: 10.1136/hrt.63.6.325. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Møller L., Kristensen T. S. Plasma fibrinogen and ischemic heart disease risk factors. Arterioscler Thromb. 1991 Mar-Apr;11(2):344–350. doi: 10.1161/01.atv.11.2.344. [DOI] [PubMed] [Google Scholar]
  16. Paffenbarger R. S., Jr, Jung D. L., Leung R. W., Hyde R. T. Physical activity and hypertension: an epidemiological view. Ann Med. 1991 Aug;23(3):319–327. doi: 10.3109/07853899109148067. [DOI] [PubMed] [Google Scholar]
  17. Reaven P. D., Barrett-Connor E., Edelstein S. Relation between leisure-time physical activity and blood pressure in older women. Circulation. 1991 Feb;83(2):559–565. doi: 10.1161/01.cir.83.2.559. [DOI] [PubMed] [Google Scholar]
  18. Rosengren A., Wilhelmsen L., Welin L., Tsipogianni A., Teger-Nilsson A. C., Wedel H. Social influences and cardiovascular risk factors as determinants of plasma fibrinogen concentration in a general population sample of middle aged men. BMJ. 1990 Mar 10;300(6725):634–638. doi: 10.1136/bmj.300.6725.634. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Shaper A. G., Wannamethee G., Weatherall R. Physical activity and ischaemic heart disease in middle-aged British men. Br Heart J. 1991 Nov;66(5):384–394. doi: 10.1136/hrt.66.5.384. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Stamler R., Stamler J., Gosch F. C., Civinelli J., Fishman J., McKeever P., McDonald A., Dyer A. R. Primary prevention of hypertension by nutritional-hygienic means. Final report of a randomized, controlled trial. JAMA. 1989 Oct 6;262(13):1801–1807. [PubMed] [Google Scholar]
  21. Uemura K., Pisa Z. Trends in cardiovascular disease mortality in industrialized countries since 1950. World Health Stat Q. 1988;41(3-4):155–178. [PubMed] [Google Scholar]
  22. Wilhelmsen L., Svärdsudd K., Korsan-Bengtsen K., Larsson B., Welin L., Tibblin G. Fibrinogen as a risk factor for stroke and myocardial infarction. N Engl J Med. 1984 Aug 23;311(8):501–505. doi: 10.1056/NEJM198408233110804. [DOI] [PubMed] [Google Scholar]

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