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Comparison of the severity of LESC-associated defects in DK and LSCD. A healthy cornea comprises the full complement of functional LESCs with no epithelial defects. DK results in the depletion and/or dysfunction of LESCs with potentially some normal LESCs remaining. LSCD is characterized by the absence of functional LESCs which triggers conjunctivalization and neovascularization, resulting in opacification of the cornea. Figure generated with BioRender.com.
