Table 1.
Main animal model studies targeting genes associated with dyslipidemia.
| Species | Delivery Vehicle | Editing Method | References | ||
|---|---|---|---|---|---|
| PCSK9 | Mouse | Adenovirus | CRISPR | [57] | |
| Mouse | AAV | CRISPR | [58] | ||
| Mouse | AAV | CRISPR | [63] | ||
| Mouse | AAV | CRISPR | [64] | ||
| Mouse | LLN | CRISPR | [65] | ||
| Mouse | LNP | CRISPR | [67] | ||
| Mouse | LNP | CRISPR | [68] | ||
| Mouse | Adenovirus | Base editor | [69] | ||
| NHP | AAV | Meganuclease | [70] | ||
| NHP | LNP | Base editor | [73] | ||
| NHP | LNP | Base editor | [74] | ||
| ANGPTL3 | Mouse | Adenovirus | Base editor | [85] | |
| Mouse | LNP | CRISPR | [88] | ||
| Mouse | AAV | Base editor | [89] | ||
| Mouse | AAV | Base editor | [90] | ||
| NHP | GalNAc-LNP | Base editor | [93] | ||
| LDLR | Mouse | AAV | CRISPR | [97] | |
| Mouse | AAV | CRISPR | [99] | ||
| Rabbit | * | CRISPR | [105] | ||
| Hamster | * | CRISPR | [106] | ||
| APO | A1 | Mouse | AAV | CRISPR | [113] |
| B | Mouse | AAV | CRISPR | [3] | |
| B | Mouse | AAV | CRISPR | [63] | |
| C3 | Hamster | * | CRISPR | [119] | |
| C3 | Rabbit | * | CRISPR | [120] | |
* = microinjections in embryos.