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Archives of Disease in Childhood. Fetal and Neonatal Edition logoLink to Archives of Disease in Childhood. Fetal and Neonatal Edition
. 1994 Jan;70(1):F47–F49. doi: 10.1136/fn.70.1.f47

Guidelines for the safe administration of inhaled nitric oxide.

O I Miller 1, D S Celermajer 1, J E Deanfield 1, D J Macrae 1
PMCID: PMC1060988  PMID: 8117128

Abstract

Inhaled nitric oxide (NO) is a selective pulmonary vasodilator, potentially useful in the treatment of pulmonary hypertension and ventilation-perfusion mismatch. High doses of inhaled NO and its oxidative product nitrogen dioxide (NO2) may cause acute lung injury. Using a standard infant ventilator, ventilator circuit and test lung, an administration and monitoring strategy has been defined for inhaled NO and these observations validated in eight ventilated infants. In 90% oxygen, doses of inhaled NO > or = 80 parts per million may result in toxic NO2 concentrations.

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Selected References

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