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Archives of Disease in Childhood. Fetal and Neonatal Edition logoLink to Archives of Disease in Childhood. Fetal and Neonatal Edition
. 1994 Jul;71(1):F20–F23. doi: 10.1136/fn.71.1.f20

Effect of aminophylline on brain stem auditory evoked potentials in preterm infants.

Y J Chen 1, C S Liou 1, C H Tsai 1, T F Yeh 1
PMCID: PMC1061062  PMID: 8092864

Abstract

To determine the neurophysiological effects of aminophylline on apnoea of prematurity, the brain stem auditory evoked potentials (BAEPs) of 30 apnoeic infants and 34 age matched controls were evaluated and compared. After six days of treatment with aminophylline, the brain stem conduction time (interpeak latency of I-V) in apnoeic infants decreased compared with controls of a similar postconceptional age. The mean latencies of the peaks and interpeaks of all waves except wave I were significantly lower in the apnoeic infants after than before receiving aminophylline. No significant differences were found in the latencies of BAEPs between the apnoeic infants who responded and those who did not respond to aminophylline treatment, however. These results suggest that aminophylline may enhance conduction along central auditory pathways and stimulate the regulatory effect on the respiratory centre of the brain stem.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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